WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561858
CAS#: 912587-25-8
Description: Opigolix, also known as ASP1707, is a small-molecule, non-peptide, orally active gonadotropin-releasing hormone antagonist (GnRH antagonist) which was under development by Astellas Pharma for the treatment of endometriosis and rheumatoid arthritis. It was also under investigation for the treatment of prostate cancer. It reached phase II clinical trials for both endometriosis and rheumatoid arthritis prior to the discontinuation of its development in April 2018.
MedKoo Cat#: 561858
Name: Opigolix
CAS#: 912587-25-8
Chemical Formula: C25H19F3N4O5S
Exact Mass: 544.1028
Molecular Weight: 544.5
Elemental Analysis: C, 55.15; H, 3.52; F, 10.47; N, 10.29; O, 14.69; S, 5.89
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Opigolix; ASP1707; ASP-1707; ASP 1707;
IUPAC/Chemical Name: (R)-N-((5-(3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)-3-oxopropanoyl)-2-fluorophenyl)sulfonyl)-2-hydroxypropanimidamide
InChi Key: CWNLBPBIFALUQD-GFCCVEGCSA-N
InChi Code: InChI=1S/C25H19F3N4O5S/c1-12(33)24(29)32-38(36,37)20-10-13(6-8-17(20)28)22(34)21(23(35)15-11-14(26)7-9-16(15)27)25-30-18-4-2-3-5-19(18)31-25/h2-12,30-31,33H,1H3,(H2,29,32)/t12-/m1/s1
SMILES Code: FC1=CC=C(F)C(C(/C(C(C2=CC=C(F)C(S(NC([C@@](O)([H])C)=N)(=O)=O)=C2)=O)=C3NC(C=CC=C4)=C4N\3)=O)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 544.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
