BO 1341

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584242

CAS#: 119068-46-1

Description: BO 1341 is a semisynthetic cephalosporin having a 6,7-dihydroxyisoquinoline moiety at the C-3 methylene carbon.


Chemical Structure

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BO 1341
CAS# 119068-46-1

Theoretical Analysis

MedKoo Cat#: 584242
Name: BO 1341
CAS#: 119068-46-1
Chemical Formula: C26H24N6O9S2
Exact Mass: 628.10
Molecular Weight: 628.631
Elemental Analysis: C, 49.68; H, 3.85; N, 13.37; O, 22.91; S, 10.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BO 1341; BO1341; BO-1341

IUPAC/Chemical Name: Isoquinolinium, 2-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydroxy-, hydroxide, inner salt, (6R-trans)-

InChi Key: XMOLQYFYIRKUAY-PLEZTBHSSA-N

InChi Code: InChI=1S/C26H24N6O9S2/c1-26(2,24(39)40)41-30-17(14-10-43-25(27)28-14)20(35)29-18-21(36)32-19(23(37)38)13(9-42-22(18)32)8-31-4-3-11-5-15(33)16(34)6-12(11)7-31/h3-7,10,18,22H,8-9H2,1-2H3,(H6,27,28,29,34,35,37,38,39,40)/b30-17+/t18-,22-/m1/s1

SMILES Code: OC1=CC2=C[N+](CC(CS[C@]3([H])[C@@H]4NC(/C(C5=CSC(N)=N5)=N/OC(C)(C(O)=O)C)=O)=C(C([O-])=O)N3C4=O)=CC=C2C=C1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 628.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hazumi N, Matsuda K, Sanada M, Ohtake N, Tanaka N. Resistance to a new catecholic cephem, BO-1341, in Pseudomonas aeruginosa PAO. J Antimicrob Chemother. 1992 Mar;29(3):287-97. PubMed PMID: 1592698.

2: Nakagawa S, Sanada M, Matsuda K, Hashizume T, Asahi Y, Ushijima R, Ohtake N, Tanaka N. In vitro and in vivo antibacterial activities of BO-1341, a new antipseudomonal cephalosporin. Antimicrob Agents Chemother. 1989 Sep;33(9):1423-7. PubMed PMID: 2510590; PubMed Central PMCID: PMC172677.

3: Sanada M, Hashizume T, Matsuda K, Nakagawa S, Tanaka N. Mode of action of BO-1341: transport pathway through the outer membrane of Escherichia coli. Drugs Exp Clin Res. 1988;14(6):397-402. PubMed PMID: 3063475.

4: Hashizume T, Sanada M, Nakagawa S, Tanaka N. Comparison of transport pathways of catechol-substituted cephalosporins, BO-1236 and BO-1341, through the outer membrane of Escherichia coli. J Antibiot (Tokyo). 1990 Dec;43(12):1617-20. PubMed PMID: 2276982.