BN 52111

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584238

CAS#: 120889-14-7

Description: BN 52111 is a platelet activating factor antagonist.

Chemical Structure

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BN 52111
CAS# 120889-14-7
Instruction

Theoretical Analysis

MedKoo Cat#: 584238
Name: BN 52111
CAS#: 120889-14-7
Chemical Formula: C33H58BrNO4
Exact Mass: 611.35
Molecular Weight: 612.734
Elemental Analysis: C, 64.69; H, 9.54; Br, 13.04; N, 2.29; O, 10.44

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BN 52111; BN-52111; BN52111

IUPAC/Chemical Name: Pyridinium, 1-(6-((2-heptadecyl-2-methyl-1,3-dioxolan-4-yl)methoxy)-6-oxohexyl)-, bromide

InChi Key: YZHGMFNGBBTPOH-UHFFFAOYSA-M

InChi Code: InChI=1S/C33H58NO4.BrH/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-25-33(2)37-30-31(38-33)29-36-32(35)24-19-17-21-26-34-27-22-18-23-28-34;/h18,22-23,27-28,31H,3-17,19-21,24-26,29-30H2,1-2H3;1H/q+1;/p-1

SMILES Code: O=C(OCC1OC(C)(CCCCCCCCCCCCCCCCC)OC1)CCCCC[N+]2=CC=CC=C2.[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 612.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Braquet P, Hosford D, Koltz P, Guilbaud J, Paubert-Braquet M. Effect of platelet-activating factor on tumor necrosis factor-induced superoxide generation from human neutrophils. Possible involvement of G proteins. Lipids. 1991 Dec;26(12):1071-5. PubMed PMID: 1668107.

2: Paubert-Braquet M, Hosford D, Klotz P, Guilbaud J, Braquet P. Tumor necrosis factor alpha 'primes' the platelet-activating factor-induced superoxide production by human neutrophils: possible involvement of G proteins. J Lipid Mediat. 1990;2 Suppl:S1-4. PubMed PMID: 1966810.

3: Pons F, Touvay C, Lejeune V, Carré C, Vilain B, Broquet C, Mencia-Huerta JM, Braquet P. Action of platelet-activating factor (PAF) antagonists on the bronchopulmonary effects of PAF in the guinea-pig. J Lipid Mediat. 1989 Nov-Dec;1(6):329-40. PubMed PMID: 2519901.

4: Mandi Y, Farkas G, Koltai M, Beladi I, Mencia-Huerta JM, Braquet P. The effect of the platelet-activating factor antagonist, BN 52021, on human natural killer cell-mediated cytotoxicity. Immunology. 1989 Jul;67(3):370-4. PubMed PMID: 2759659; PubMed Central PMCID: PMC1385355.

5: Thivierge M, Rola-Pleszczynski M. Enhancement of pulmonary natural killer cell activity by platelet activating factor. Mechanisms of activation involving Ca2+, protein kinase C, and lipooxygenase products. Am Rev Respir Dis. 1991 Aug;144(2):272-7. PubMed PMID: 1650153.

6: Domingo MT, Piro F, Broquet C, Auclair E, Chabrier PE, Braquet P. Reversible or irreversible modification of [3H]PAF binding on rabbit platelet membranes differentiates various PAF receptor antagonists. Lipids. 1992 Aug;27(8):582-6. PubMed PMID: 1328798.