OMDM169

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555132

CAS#: 130193-44-1

Description: OMDM169 is a potent and selective MAGL inhibitor. OMDM169 is capable of enhancing 2-AG levels and of exerting analgesic activity via indirect activation of cannabinoid receptors. OMDM169 exhibited 0.13 microM10 microM) at human CB(1) and CB(2) receptors. OMDM69 might represent a template for the development of selective and even more potent inhibitors of 2-AG hydrolysis.


Chemical Structure

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OMDM169
CAS# 130193-44-1

Theoretical Analysis

MedKoo Cat#: 555132
Name: OMDM169
CAS#: 130193-44-1
Chemical Formula: C25H45NO5
Exact Mass: 439.33
Molecular Weight: 439.637
Elemental Analysis: C, 68.30; H, 10.32; N, 3.19; O, 18.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: OMDM169; OMDM-169; OMDM 169.

IUPAC/Chemical Name: (S)-1-((2S,3S)-3-hexyl-4-oxooxetan-2-yl)tridecan-2-yl formylglycinate

InChi Key: ANPULBVRORHAGO-VABKMULXSA-N

InChi Code: InChI=1S/C25H45NO5/c1-3-5-7-9-10-11-12-13-14-16-21(30-24(28)19-26-20-27)18-23-22(25(29)31-23)17-15-8-6-4-2/h20-23H,3-19H2,1-2H3,(H,26,27)/t21-,22-,23-/m0/s1

SMILES Code: O=C(O[C@@H](CCCCCCCCCCC)C[C@@H]([C@@H]1CCCCCC)OC1=O)CNC=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: However, OMDM169 shared with tetrahydrolipstatin the capability of inhibiting the human pancreatic lipase (IC(50)=0.6 microM). OMDM169 inhibited fatty acid amide hydrolase and diacylglycerol lipase only at higher concentrations (IC(50)=3.0 and 2.8 microM, respectively), and, accordingly, it increased by approximately 1.6-fold the levels of 2-AG, but not anandamide, in intact ionomycin-stimulated N18TG2 neuroblastoma cells. Acute intraperitoneal (i.p.) administration of OMDM169 to mice inhibited the second phase of the formalin-induced nocifensive response with an IC(50) of approximately 2.5 mg/kg, and concomitantly elevated 2-AG, but not anandamide, levels in the ipsilateral paw of formalin-treated mice. The antinociceptive effect of OMDM169 was antagonized by antagonists of CB(1) and CB(2) receptors, AM251 and AM630, respectively (1 mg/kg, i.p.).

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 439.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Valdeolivas S, Pazos MR, Bisogno T, Piscitelli F, Iannotti FA, Allarà M,
Sagredo O, Di Marzo V, Fernández-Ruiz J. The inhibition of
2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal
damage, protects striatal neurons from malonate-induced death: a potential role
of cyclooxygenase-2-dependent metabolism of 2-AG. Cell Death Dis. 2013 Oct
17;4:e862. doi: 10.1038/cddis.2013.387. PubMed PMID: 24136226; PubMed Central
PMCID: PMC3920947.


2: Bisogno T, Ortar G, Petrosino S, Morera E, Palazzo E, Nalli M, Maione S, Di
Marzo V; Endocannabinoid Research Group. Development of a potent inhibitor of
2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. Biochim
Biophys Acta. 2009 Jan;1791(1):53-60. doi: 10.1016/j.bbalip.2008.10.007. Epub
2008 Nov 5. PubMed PMID: 19027877.