WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206858
CAS#: 1952236-05-3
Description: MTX-211 is a dual inhibitor of EGFR and PI3K. MTX-211 is potentially useful for treatment of KRAS mutant colorectal cancer.
MedKoo Cat#: 206858
Name: MTX-211
CAS#: 1952236-05-3
Chemical Formula: C20H14Cl2FN5O2S
Exact Mass: 477.0229
Molecular Weight: 478.3234
Elemental Analysis: C, 50.22; H, 2.95; Cl, 14.82; F, 3.97; N, 14.64; O, 6.69; S, 6.70
Synonym: MTX-211; MTX211; MTX 211.
IUPAC/Chemical Name: N-[2-chloro-5-[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]pyridin-3-yl]methanesulfonamide
InChi Key: GUYKCXXNIKKSBC-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H14Cl2FN5O2S/c1-31(29,30)28-18-7-12(9-24-19(18)22)11-2-5-17-14(6-11)20(26-10-25-17)27-13-3-4-16(23)15(21)8-13/h2-10,28H,1H3,(H,25,26,27)
SMILES Code: CS(=O)(NC1=CC(C2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2)=CN=C1Cl)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 478.3234 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
