WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 527673
CAS#: 158093-65-3
Description: PU139 is a novel histone acetyltransferase (HAT) inhibitor.
MedKoo Cat#: 527673
Name: PU139
CAS#: 158093-65-3
Chemical Formula: C12H7FN2OS
Exact Mass: 246.0263
Molecular Weight: 246.2594
Elemental Analysis: C, 58.53; H, 2.87; F, 7.71; N, 11.38; O, 6.50; S, 13.02
Synonym: PU139; PU-139; PU 139
IUPAC/Chemical Name: 2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
InChi Key: QMCIVCACYJRAAY-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H7FN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H
SMILES Code: O=C1N(C2=CC=C(F)C=C2)SC3=NC=CC=C31
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 246.2594 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Gajer JM, Furdas SD, Gründer A, Gothwal M, Heinicke U, Keller K, Colland F, Fulda S, Pahl HL, Fichtner I, Sippl W, Jung M. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis. 2015 Feb 9;4:e137. doi: 10.1038/oncsis.2014.51. PubMed PMID: 25664930; PubMed Central PMCID: PMC4338425.
2: Carneiro VC, de Abreu da Silva IC, Torres EJ, Caby S, Lancelot J, Vanderstraete M, Furdas SD, Jung M, Pierce RJ, Fantappié MR. Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis. PLoS Pathog. 2014 May 8;10(5):e1004116. doi: 10.1371/journal.ppat.1004116. eCollection 2014 May. PubMed PMID: 24809504; PubMed Central PMCID: PMC4014452.
