WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 527672
CAS#: 168334-34-7
Description: PU141 is a novel histone acetyltransferase (HAT) inhibitor.
MedKoo Cat#: 527672
Name: PU141
CAS#: 168334-34-7
Chemical Formula: C14H9F3N2OS
Exact Mass: 310.0388
Molecular Weight: 310.2942
Elemental Analysis: C, 54.19; H, 2.92; F, 18.37; N, 9.03; O, 5.16; S, 10.33
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: PU 141; PU-141; PU141
IUPAC/Chemical Name: 2-[[4-(Trifluoromethyl)phenyl]methyl]isothiazolo[5,4-b]pyridin-3(2H)-one
InChi Key: UQVNCGIZTSUQOC-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H9F3N2OS/c15-14(16,17)10-5-3-9(4-6-10)8-19-13(20)11-2-1-7-18-12(11)21-19/h1-7H,8H2
SMILES Code: O=C1N(CC2=CC=C(C(F)(F)F)C=C2)SC3=NC=CC=C31
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 310.2942 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Gajer JM, Furdas SD, Gründer A, Gothwal M, Heinicke U, Keller K, Colland F, Fulda S, Pahl HL, Fichtner I, Sippl W, Jung M. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis. 2015 Feb 9;4:e137. doi: 10.1038/oncsis.2014.51. PubMed PMID: 25664930; PubMed Central PMCID: PMC4338425.
