NSC-636819
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527664

CAS#: 1618672-71-1

Description: NSC-636819 is a novel KDM4A/KDM4B inhibitor.

Chemical Structure

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NSC-636819
CAS# 1618672-71-1
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 527664
Name: NSC-636819
CAS#: 1618672-71-1
Chemical Formula: C22H12Cl4N2O4
Exact Mass: 507.96
Molecular Weight: 510.148
Elemental Analysis: C, 51.80; H, 2.37; Cl, 27.80; N, 5.49; O, 12.54

Price and Availability

Size Price Availability Quantity
10mg USD 400 2 Weeks
50mg USD 1360 2 Weeks
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Synonym: NSC 636819; NSC636819; NSC-636819

IUPAC/Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene

InChi Key: YYZPXBXVBQSBDG-IJIVKGSJSA-N

InChi Code: InChI=1S/C22H12Cl4N2O4/c23-17-7-3-13(9-19(17)25)1-5-15-11-16(22(28(31)32)12-21(15)27(29)30)6-2-14-4-8-18(24)20(26)10-14/h1-12H/b5-1+,6-2+

SMILES Code: O=[N+](C1=C(/C=C/C2=CC=C(Cl)C(Cl)=C2)C=C(/C=C/C3=CC=C(Cl)C(Cl)=C3)C([N+]([O-])=O)=C1)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: NSC636819 is a competitive and selective inhibitor of KDM4A/KDM4B.
In vitro activity: Further kinetic inhibition characterization of compound 4 (NSC636819) demonstrated a competitive inhibitory mode against H33–17K9me3 for KDM4A [IC50 = 6.4 μM; Ki (H3K9me3) = 5.5 ± 1.6 μM; Figure 3B). This study further characterized the methylated status of H3 in LNCaP cells treated with compound 4. As shown in Figure S4B, only the level of H3K9me3 was significantly increased in compound 4-treated LNCaP cells as opposed to essentially comparable signals of H3K4me2, H3K27me3, H3K27me2, H3K36me3, H3K36me2, and H3K79me2 between control and treated cells. Reference: J Med Chem. 2014 Jul 24;57(14):5975-85. https://pubmed.ncbi.nlm.nih.gov/24971742/
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.1 10.00

Preparing Stock Solutions

The following data is based on the product molecular weight 510.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: Chu CH, Wang LY, Hsu KC, Chen CC, Cheng HH, Wang SM, Wu CM, Chen TJ, Li LT, Liu R, Hung CL, Yang JM, Kung HJ, Wang WC. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J Med Chem. 2014 Jul 24;57(14):5975-85. doi: 10.1021/jm500249n. Epub 2014 Jul 9. PMID: 24971742; PMCID: PMC4216216.
In vitro protocol: Chu CH, Wang LY, Hsu KC, Chen CC, Cheng HH, Wang SM, Wu CM, Chen TJ, Li LT, Liu R, Hung CL, Yang JM, Kung HJ, Wang WC. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J Med Chem. 2014 Jul 24;57(14):5975-85. doi: 10.1021/jm500249n. Epub 2014 Jul 9. PMID: 24971742; PMCID: PMC4216216.
In vivo protocol: TBD

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1: Chu CH, Wang LY, Hsu KC, Chen CC, Cheng HH, Wang SM, Wu CM, Chen TJ, Li LT, Liu R, Hung CL, Yang JM, Kung HJ, Wang WC. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J Med Chem. 2014 Jul 24;57(14):5975-85. doi: 10.1021/jm500249n. Epub 2014 Jul 9. PubMed PMID: 24971742; PubMed Central PMCID: PMC4216216.