NSC1011

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MedKoo CAT#: 527662

CAS#: 5335-97-7

Description: NSC1011 is a ras converting enzyme 1 (Rce1) inhibitor.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-03. Prices are subject to change without notice.

NSC1011 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 527662
Name: NSC1011
CAS#: 5335-97-7
Chemical Formula: C23H18N2O3
Exact Mass: 370.1317
Molecular Weight: 370.408
Elemental Analysis: C, 74.58; H, 4.90; N, 7.56; O, 12.96


Synonym: NSC 1011; NSC-1011; NSC1011

IUPAC/Chemical Name: 4-[[(8-Hydroxyquinolin-7-yl)-phenylmethyl]amino]benzoic acid

InChi Key: PSCFZETTYRDCRM-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H18N2O3/c26-22-19(13-10-16-7-4-14-24-21(16)22)20(15-5-2-1-3-6-15)25-18-11-8-17(9-12-18)23(27)28/h1-14,20,25-26H,(H,27,28)

SMILES Code: O=C(O)C1=CC=C(NC(C2=CC=C3C=CC=NC3=C2O)C4=CC=CC=C4)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Mohammed I, Hampton SE, Ashall L, Hildebrandt ER, Kutlik RA, Manandhar SP, Floyd BJ, Smith HE, Dozier JK, Distefano MD, Schmidt WK, Dore TM. 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorg Med Chem. 2016 Jan 15;24(2):160-78. doi: 10.1016/j.bmc.2015.11.043. Epub 2015 Nov 30. PubMed PMID: 26706114; PubMed Central PMCID: PMC4749511.