Irampanel

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584214

CAS#: 206260-33-5

Description: Irampanel is an anticonvulsant and neuroprotectant.


Chemical Structure

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Irampanel
CAS# 206260-33-5

Theoretical Analysis

MedKoo Cat#: 584214
Name: Irampanel
CAS#: 206260-33-5
Chemical Formula: C18H19N3O2
Exact Mass: 309.15
Molecular Weight: 309.369
Elemental Analysis: C, 69.88; H, 6.19; N, 13.58; O, 10.34

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Irampanel; BIIR-561CL

IUPAC/Chemical Name: 5-(o-(2-(Dimethylamino)ethoxy)phenyl)-3-phenyl-1,2,4-oxadiazole.

InChi Key: QZULPCPLWGCGSL-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H19N3O2/c1-21(2)12-13-22-16-11-7-6-10-15(16)18-19-17(20-23-18)14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3

SMILES Code: CN(CCOC1=CC=CC=C1C2=NC(C3=CC=CC=C3)=NO2)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 309.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Feigin V. Irampanel Boehringer Ingelheim. Curr Opin Investig Drugs. 2002 Jun;3(6):908-10. Review. PubMed PMID: 12137411.

2: Wienrich M, Brenner M, Löscher W, Palluk R, Pieper M, Potschka H, Weiser T. In vivo pharmacology of BIIR 561 CL, a novel combined antagonist of AMPA receptors and voltage-dependent Na(+) channels. Br J Pharmacol. 2001 Jul;133(6):789-96. PubMed PMID: 11454651; PubMed Central PMCID: PMC1572840.

3: Weiser T, Wienrich M, Brenner M, Kubiak R, Weckesser G, Palluk R. The AMPA receptor/Na(+) channel blocker BIIR 561 CL is protective in a model of global cerebral ischaemia. Eur J Pharmacol. 2001 Jun 15;421(3):165-70. PubMed PMID: 11516432.

4: Weiser T, Iizuka M, Nishimura S, Akiba I, Barsoumian E, Zhou M, Steinhäuser C, Brenner M, Palluk R, Wienrich M. Characterization of the anticonvulsant and neuroprotectant BIIR 561 CL in vitro: effects on native and recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):419-26. PubMed PMID: 11111837.

5: Weiser T, Brenner M, Palluk R, Bechtel WD, Ceci A, Brambilla A, Ensinger HA, Sagrada A, Wienrich M. BIIR 561 CL: a novel combined antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and voltage-dependent sodium channels with anticonvulsive and neuroprotective properties. J Pharmacol Exp Ther. 1999 Jun;289(3):1343-9. PubMed PMID: 10336525.