CABP

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561811

CAS#: 27442-42-8

Description: CABP is a transition state analog of ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco).


Chemical Structure

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CABP
CAS# 27442-42-8

Theoretical Analysis

MedKoo Cat#: 561811
Name: CABP
CAS#: 27442-42-8
Chemical Formula: C6H14O13P2
Exact Mass: 355.99
Molecular Weight: 356.110
Elemental Analysis: C, 20.24; H, 3.96; O, 58.40; P, 17.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CABP; 2-CABP; 2 CABP; 2CABP; 2-Carboxy-D-arabinitol 1,5-bisphosphate; 2-Carboxy-D-arabinitol 1,5-diphosphate; 2-Carboxyarabinitol 1,5-diphosphate;

IUPAC/Chemical Name: (2R,3R,4R)-2,3,4-trihydroxy-5-phosphonooxy-2-(phosphonooxymethyl)pentanoic acid

InChi Key: ITHCSGCUQDMYAI-ZMIZWQJLSA-N

InChi Code: InChI=1S/C6H14O13P2/c7-3(1-18-20(12,13)14)4(8)6(11,5(9)10)2-19-21(15,16)17/h3-4,7-8,11H,1-2H2,(H,9,10)(H2,12,13,14)(H2,15,16,17)/t3-,4-,6-/m1/s1

SMILES Code: O=C(O)[C@](COP(O)(O)=O)(O)[C@H](O)[C@H](O)COP(O)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 356.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Donald BJ, Surani S, Deol HS, Mbadugha UJ, Udeani G. Spotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy. Drug Des Devel Ther. 2017 Dec 13;11:3559-3566. doi: 10.2147/DDDT.S119545. eCollection 2017. Review. PubMed PMID: 29263651; PubMed Central PMCID: PMC5732564.

2: Li Q, Zhao X, Wang S, Zhou Z. Letrozole induced low estrogen levels affected the expressions of duodenal and renal calcium-processing gene in laying hens. Gen Comp Endocrinol. 2018 Jan 1;255:49-55. doi: 10.1016/j.ygcen.2017.10.005. Epub 2017 Oct 14. Review. PubMed PMID: 29037849.

3: Buege MJ, Brown JE, Aitken SL. Solithromycin: A novel ketolide antibiotic. Am J Health Syst Pharm. 2017 Jun 15;74(12):875-887. doi: 10.2146/ajhp160934. Epub 2017 Apr 21. Review. PubMed PMID: 28432048.

4: Yim J, Molloy LM, Newland JG. Use of Ceftaroline Fosamil in Children: Review of Current Knowledge and its Application. Infect Dis Ther. 2017 Mar;6(1):57-67. doi: 10.1007/s40121-016-0144-8. Epub 2016 Dec 30. Review. PubMed PMID: 28039666; PubMed Central PMCID: PMC5336419.

5: Zhanel GG, Hartel E, Adam H, Zelenitsky S, Zhanel MA, Golden A, Schweizer F, Gorityala B, Lagacé-Wiens PR, Walkty AJ, Gin AS, Hoban DJ, Lynch JP 3rd, Karlowsky JA. Solithromycin: A Novel Fluoroketolide for the Treatment of Community-Acquired Bacterial Pneumonia. Drugs. 2016 Dec;76(18):1737-1757. Review. PubMed PMID: 27909995.

6: Fernandes P, Martens E. Antibiotics in late clinical development. Biochem Pharmacol. 2017 Jun 1;133:152-163. doi: 10.1016/j.bcp.2016.09.025. Epub 2016 Sep 26. Review. PubMed PMID: 27687641.

7: Hadzic M, Jack A, Wahle P. Ionotropic glutamate receptors: Which ones, when, and where in the mammalian neocortex. J Comp Neurol. 2017 Mar 1;525(4):976-1033. doi: 10.1002/cne.24103. Epub 2016 Sep 27. Review. PubMed PMID: 27560295.

8: Thomas CM, Timson DJ. A mysterious family of calcium-binding proteins from parasitic worms. Biochem Soc Trans. 2016 Aug 15;44(4):1005-10. doi: 10.1042/BST20150270. Review. PubMed PMID: 27528745.

9: Tanaka SK, Steenbergen J, Villano S. Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic. Bioorg Med Chem. 2016 Dec 15;24(24):6409-6419. doi: 10.1016/j.bmc.2016.07.029. Epub 2016 Jul 18. Review. PubMed PMID: 27469981.

10: Jones TM, Johnson SW, DiMondi VP, Wilson DT. Focus on JNJ-Q2, a novel fluoroquinolone, for the management of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. Infect Drug Resist. 2016 Jun 7;9:119-28. doi: 10.2147/IDR.S105620. eCollection 2016. Review. PubMed PMID: 27354817; PubMed Central PMCID: PMC4908938.

11: Gorkhali R, Huang K, Kirberger M, Yang JJ. Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach. Metallomics. 2016 Jun 1;8(6):563-78. doi: 10.1039/c6mt00038j. Review. PubMed PMID: 27108875; PubMed Central PMCID: PMC4979543.

12: Van Bambeke F, Tulkens PM. The role of solithromycin in the management of bacterial community-acquired pneumonia. Expert Rev Anti Infect Ther. 2016;14(3):311-24. doi: 10.1586/14787210.2016.1138857. Epub 2016 Feb 5. Review. PubMed PMID: 26848612.

13: Lehmann H, Pabst JY. [Phytovigilance: A medical requirement and a legal obligation]. Ann Pharm Fr. 2016 Jan;74(1):49-60. doi: 10.1016/j.pharma.2015.06.004. Epub 2015 Jul 22. Review. French. PubMed PMID: 26210820.

14: Yoneda T, Hiasa M, Nagata Y, Okui T, White FA. Acidic microenvironment and bone pain in cancer-colonized bone. Bonekey Rep. 2015 May 6;4:690. doi: 10.1038/bonekey.2015.58. eCollection 2015. Review. PubMed PMID: 25987988; PubMed Central PMCID: PMC4422089.

15: Yoneda T, Hiasa M, Nagata Y, Okui T, White F. Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain. Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2677-84. doi: 10.1016/j.bbamem.2015.02.004. Epub 2015 Feb 14. Review. PubMed PMID: 25687976; PubMed Central PMCID: PMC5356024.

16: Stryjewski ME, Jones RN, Corey GR. Ceftaroline: clinical and microbiology experience with focus on methicillin-resistant Staphylococcus aureus after regulatory approval in the USA. Diagn Microbiol Infect Dis. 2015 Mar;81(3):183-8. doi: 10.1016/j.diagmicrobio.2014.11.016. Epub 2014 Dec 3. Review. PubMed PMID: 25583130.

17: Merker A, Danziger LH, Rodvold KA, Glowacki RC. Pharmacokinetic and pharmacodynamic evaluation of ceftaroline fosamil. Expert Opin Drug Metab Toxicol. 2014 Dec;10(12):1741-50. doi: 10.1517/17425255.2014.972932. Epub 2014 Oct 27. Review. PubMed PMID: 25347329.

18: Carreno JJ, Lodise TP. Ceftaroline Fosamil for the Treatment of Community-Acquired Pneumonia: from FOCUS to CAPTURE. Infect Dis Ther. 2014 Dec;3(2):123-32. doi: 10.1007/s40121-014-0036-8. Epub 2014 Sep 6. Review. PubMed PMID: 25193094; PubMed Central PMCID: PMC4269637.

19: Amin AN, Cerceo EA, Deitelzweig SB, Pile JC, Rosenberg DJ, Sherman BM. The hospitalist perspective on treatment of community-acquired bacterial pneumonia. Postgrad Med. 2014 Mar;126(2):18-29. doi: 10.3810/pgm.2014.03.2737. Review. PubMed PMID: 24685965.

20: Srivastava SS, Mishra A, Krishnan B, Sharma Y. Ca2+-binding motif of βγ-crystallins. J Biol Chem. 2014 Apr 18;289(16):10958-66. doi: 10.1074/jbc.O113.539569. Epub 2014 Feb 24. Review. PubMed PMID: 24567326; PubMed Central PMCID: PMC4036236.