Dehydrocostus Lactone
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MedKoo CAT#: 329899

CAS#: 477-43-0

Description: Dehydrocostus Lactone is a natural sesquiterpene first isolated from costus root, which is used in traditional medicine. Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ. Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways. Dehydrocostus Lactone Inhibits Proliferation, Antiapoptosis, and Invasion of Cervical Cancer Cells Through PI3K/Akt Signaling Pathway.


Chemical Structure

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Dehydrocostus Lactone
CAS# 477-43-0

Theoretical Analysis

MedKoo Cat#: 329899
Name: Dehydrocostus Lactone
CAS#: 477-43-0
Chemical Formula: C15H18O2
Exact Mass: 230.13
Molecular Weight: 230.307
Elemental Analysis: C, 78.23; H, 7.88; O, 13.89

Price and Availability

Size Price Availability Quantity
10mg USD 225
50mg USD 485
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Synonym: Dehydrocostus Lactone; (-)-Dehydrocostus lactone.

IUPAC/Chemical Name: (3aS,6aR,9aR,9bS)-3,6,9-trimethylenedecahydroazuleno[4,5-b]furan-2(3H)-one

InChi Key: NETSQGRTUNRXEO-XUXIUFHCSA-N

InChi Code: InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1

SMILES Code: C=C([C@H](CC1)[C@H](O2)[C@]3([H])[C@](CCC3=C)([H])C1=C)C2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 230.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang J, Yu Z, Wang C, Tian X, Huo X, Wang Y, Sun C, Feng L, Ma J, Zhang B, Yang Q, Ma X, Xu Y. Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ. Am J Cancer Res. 2017 Jun 1;7(6):1270-1284. eCollection 2017. PubMed PMID: 28670490; PubMed Central PMCID: PMC5489777.

2: Cai H, Qin X, Yang C. Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways. J Cell Biochem. 2017 Oct;118(10):3381-3390. doi: 10.1002/jcb.25994. Epub 2017 May 3. PubMed PMID: 28300289.

3: Yang M, Zhang J, Li Y, Han X, Gao K, Fang J. Bioassay-guided isolation of dehydrocostus lactone from Saussurea lappa: A new targeted cytosolic thioredoxin reductase anticancer agent. Arch Biochem Biophys. 2016 Oct 1;607:20-6. doi: 10.1016/j.abb.2016.08.008. Epub 2016 Aug 18. PubMed PMID: 27545438.

4: Jiang E, Sun X, Kang H, Sun L, An W, Yao Y, Hu X. Dehydrocostus Lactone Inhibits Proliferation, Antiapoptosis, and Invasion of Cervical Cancer Cells Through PI3K/Akt Signaling Pathway. Int J Gynecol Cancer. 2015 Sep;25(7):1179-86. doi: 10.1097/IGC.0000000000000474. PubMed PMID: 26017248.

5: Sun X, Kang H, Yao Y, Chen H, Sun L, An W, Jiang E, Wang S, Hu X. Dehydrocostus lactone suppressed the proliferation, migration, and invasion of colorectal carcinoma through the downregulation of eIF4E expression. Anticancer Drugs. 2015 Jul;26(6):641-8. doi: 10.1097/CAD.0000000000000229. PubMed PMID: 25850883.

6: Rao Vadaparthi PR, Kumar K, Sarma VU, Hussain QA, Babu KS. Estimation of Costunolide and Dehydrocostus Lactone in Saussurea lappa and its Polyherbal Formulations followed by their Stability Studies Using HPLC-DAD. Pharmacogn Mag. 2015 Jan-Mar;11(41):180-90. doi: 10.4103/0973-1296.149736. PubMed PMID: 25709231; PubMed Central PMCID: PMC4329622.

7: Dong GZ, Shim AR, Hyeon JS, Lee HJ, Ryu JH. Inhibition of Wnt/β-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells. Phytother Res. 2015 May;29(5):680-6. doi: 10.1002/ptr.5299. Epub 2015 Jan 27. PubMed PMID: 25625870.

8: Peng Z, Wang Y, Gu X, Guo X, Yan C. Study on the pharmacokinetics and metabolism of costunolide and dehydrocostus lactone in rats by HPLC-UV and UPLC-Q-TOF/MS. Biomed Chromatogr. 2014 Oct;28(10):1325-34. doi: 10.1002/bmc.3167. Epub 2014 Jun 2. PubMed PMID: 24889523.

9: Lee HK, Song HE, Lee HB, Kim CS, Koketsu M, Ngan LT, Ahn YJ. Growth inhibitory, bactericidal, and morphostructural effects of dehydrocostus lactone from Magnolia sieboldii Leaves on antibiotic-susceptible and -resistant strains of Helicobacter pylori. PLoS One. 2014 Apr 18;9(4):e95530. doi: 10.1371/journal.pone.0095530. eCollection 2014. PubMed PMID: 24747984; PubMed Central PMCID: PMC3991664.

10: Kretschmer N, Rinner B, Stuendl N, Kaltenegger H, Wolf E, Kunert O, Boechzelt H, Leithner A, Bauer R, Lohberger B. Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells. Planta Med. 2012 Nov;78(16):1749-56. doi: 10.1055/s-0032-1315385. Epub 2012 Oct 9. PubMed PMID: 23047249.

11: Seo MS, Choi EM. The effects of dehydrocostus lactone on osteoblastic MC3T3-E1 cells in redox changes and PI3K/Akt/CREB. Immunopharmacol Immunotoxicol. 2012 Oct;34(5):810-4. doi: 10.3109/08923973.2012.657799. Epub 2012 Feb 11. PubMed PMID: 22324303.

12: Kim EJ, Hong JE, Lim SS, Kwon GT, Kim J, Kim JS, Lee KW, Park JH. The hexane extract of Saussurea lappa and its active principle, dehydrocostus lactone, inhibit prostate cancer cell migration. J Med Food. 2012 Jan;15(1):24-32. doi: 10.1089/jmf.2011.1735. Epub 2011 Nov 14. PubMed PMID: 22082097.

13: Choi EM. Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. Eur J Pharmacol. 2011 Aug 16;664(1-3):1-7. doi: 10.1016/j.ejphar.2011.05.005. Epub 2011 May 11. PubMed PMID: 21596031.

14: Joel DM, Chaudhuri SK, Plakhine D, Ziadna H, Steffens JC. Dehydrocostus lactone is exuded from sunflower roots and stimulates germination of the root parasite Orobanche cumana. Phytochemistry. 2011 May;72(7):624-34. doi: 10.1016/j.phytochem.2011.01.037. Epub 2011 Feb 24. PubMed PMID: 21353686.

15: Choi EM, Kim GH, Lee YS. Protective effects of dehydrocostus lactone against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells. Toxicol In Vitro. 2009 Aug;23(5):862-7. doi: 10.1016/j.tiv.2009.05.005. Epub 2009 May 18. PubMed PMID: 19457452.

16: Kim EJ, Lim SS, Park SY, Shin HK, Kim JS, Park JH. Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. Food Chem Toxicol. 2008 Dec;46(12):3651-8. doi: 10.1016/j.fct.2008.08.038. Epub 2008 Sep 23. PubMed PMID: 18848968.

17: Jeong GS, Pae HO, Jeong SO, Kim YC, Kwon TO, Lee HS, Kim NS, Park SD, Chung HT. The alpha-methylene-gamma-butyrolactone moiety in dehydrocostus lactone is responsible for cytoprotective heme oxygenase-1 expression through activation of the nuclear factor E2-related factor 2 in HepG2 cells. Eur J Pharmacol. 2007 Jun 22;565(1-3):37-44. Epub 2007 Mar 7. PubMed PMID: 17391667.

18: Oh GS, Pae HO, Chung HT, Kwon JW, Lee JH, Kwon TO, Kwon SY, Chon BH, Yun YG. Dehydrocostus lactone enhances tumor necrosis factor-alpha-induced apoptosis of human leukemia HL-60 cells. Immunopharmacol Immunotoxicol. 2004 May;26(2):163-75. PubMed PMID: 15209353.

19: Lee HJ, Kim NY, Jang MK, Son HJ, Kim KM, Sohn DH, Lee SH, Ryu JH. A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. Planta Med. 1999 Mar;65(2):104-8. PubMed PMID: 10193198.

20: Yuuya S, Hagiwara H, Suzuki T, Ando M, Yamada A, Suda K, Kataoka T, Nagai K. Guaianolides as immunomodulators. Synthesis and biological activities of dehydrocostus lactone, mokko lactone, eremanthin, and their derivatives. J Nat Prod. 1999 Jan;62(1):22-30. PubMed PMID: 9917276.