WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561804

CAS#: 1202388-64-4

Description: IAXO-101 interferes with human, rat and mouse TLR4/CD14 signaling.

Chemical Structure

CAS# 1202388-64-4

Theoretical Analysis

MedKoo Cat#: 561804
Name: IAXO-101
CAS#: 1202388-64-4
Chemical Formula: C42H84INO5
Exact Mass:
Molecular Weight: 810.04
Elemental Analysis: C, 62.28; H, 10.45; I, 15.67; N, 1.73; O, 9.88

Size Price Shipping out time Quantity
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Pricing updated 2021-03-06. Prices are subject to change without notice.

IAXO-101 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: IAXO-101; IAXO 101; IAXO101;

IUPAC/Chemical Name: N-(((2R,3R,4S,5R,6S)-3-hydroxy-6-methoxy-4,5-bis(tetradecyloxy)tetrahydro-2H-pyran-2-yl)methyl)-N,N-dimethylcyclopentanaminium iodide


InChi Code: InChI=1S/C42H84NO5.HI/c1-6-8-10-12-14-16-18-20-22-24-26-30-34-46-40-39(44)38(36-43(3,4)37-32-28-29-33-37)48-42(45-5)41(40)47-35-31-27-25-23-21-19-17-15-13-11-9-7-2;/h37-42,44H,6-36H2,1-5H3;1H/q+1;/p-1/t38-,39-,40+,41-,42+;/m1./s1


Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 810.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Hermann JK, Ravikumar M, Shoffstall A, Ereifej ES, Kovach K, Chang J, Soffer A, Wong CT, Srivastava V, Smith P, Protasiewicz G, Jiang J, Selkirk S, Miller RH, Sidik S, Ziats NP, Taylor D, Capadona JR. Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance. J Neural Eng. 2017 Dec 8. doi: 10.1088/1741-2552/aaa03e. [Epub ahead of print] PubMed PMID: 29219114.

2: Barboza R, Lima FA, Reis AS, Murillo OJ, Peixoto EPM, Bandeira CL, Fotoran WL, Sardinha LR, Wunderlich G, Bevilacqua E, Lima MRD, Alvarez JM, Costa FTM, Gonçalves LA, Epiphanio S, Marinho CRF. TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria. Sci Rep. 2017 Aug 17;7(1):8623. doi: 10.1038/s41598-017-08299-x. PubMed PMID: 28819109; PubMed Central PMCID: PMC5561130.