Bietaserpine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584207

CAS#: 53-18-9

Description: Bietaserpine is a hypotensive biochemical that has also been shown to reduce tumor size in mice.

Chemical Structure

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Bietaserpine
CAS# 53-18-9
Instruction

Theoretical Analysis

MedKoo Cat#: 584207
Name: Bietaserpine
CAS#: 53-18-9
Chemical Formula: C39H53N3O9
Exact Mass: 707.38
Molecular Weight: 707.865
Elemental Analysis: C, 66.17; H, 7.55; N, 5.94; O, 20.34

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Bietaserpine; Bietaserpinum; Bietasperine; DL 152

IUPAC/Chemical Name: Methyl 1-(2-(diethylamino)ethyl)-18beta-hydroxy-11,17alpha-dimethoxy-3beta,20alpha-yohimban-16beta-carboxylate, 3,4,5-trimethoxybenzoate (ester)

InChi Key: WFTSRDISOMSAQC-ZNFOTRSXSA-N

InChi Code: InChI=1S/C39H53N3O9/c1-9-40(10-2)15-16-42-29-20-25(45-3)11-12-26(29)27-13-14-41-22-24-19-33(37(49-7)34(39(44)50-8)28(24)21-30(41)35(27)42)51-38(43)23-17-31(46-4)36(48-6)32(18-23)47-5/h11-12,17-18,20,24,28,30,33-34,37H,9-10,13-16,19,21-22H2,1-8H3/t24-,28+,30-,33-,34+,37+/m1/s1

SMILES Code: [H][C@@]12C(N(CCN(CC)CC)C3=C4C=CC(OC)=C3)=C4CCN1C[C@]5(C[C@@H](OC(C6=CC(OC)=C(OC)C(OC)=C6)=O)[C@H](OC)[C@@H](C(OC)=O)[C@]5(C2)[H])[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 707.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lehnert S. Factors influencing the toxicity of diethylaminoethylreserpine to tumor cells: studies with four transplantable tumors. Oncology. 1987;44(6):386-91. PubMed PMID: 3684180.

2: Pous Miralles G, García-Domenech R, Mañes Vinuesa J, Marí Buigues J. Spectrophotometric determination of dihydralazine in pharmaceuticals after derivatization with 2-hydroxy-1-naphthaldehyde. J Pharm Biomed Anal. 1993 Aug;11(8):647-50. PubMed PMID: 8257729.

3: Lehnert S, Fisher G, Methot G. Radioprotection of normal and malignant tissue in the mouse by diethylaminoreserpine. Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Jul;40(1):63-73. PubMed PMID: 6973553.

4: Lehnert S. Interaction of diethylaminoreserpine with cells of a transplantable tumour in vivo. Br J Cancer. 1984 Dec;50(6):847-51. PubMed PMID: 6498082; PubMed Central PMCID: PMC1976995.

5: Lehnert S. Toxicity of diethylaminoreserpine to a transplantable tumor: the significance of the presence of hypoxic cells. Cancer Res. 1982 Aug;42(8):3028-32. PubMed PMID: 7093951.

6: Lehnert S. Toxicity to tumour cells of diethylaminoreserpine. Br J Cancer Suppl. 1980 Apr;4:222-5. PubMed PMID: 6932928; PubMed Central PMCID: PMC2149265.

7: Lehnert S. Toxicity of diethylaminoreserpine to tumor cells: effects of drug alone and in combination with radiation. Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):505-9. PubMed PMID: 7107375.

8: QUEVAUVILLER A, BLANPIN O, COIGNARD D, LHUILLIER C. [PHARMACODYNAMIC RESEARCH ON N-DIETHYLAMINOETHYL-RESERPINE ACID BITARTRATE (DL-152)]. Therapie. 1963 Nov-Dec;18:1429-37. French. PubMed PMID: 14117538.

9: Murakami M, Sekimoto H, Nakat I, Iwaki N, Nakai T. [Comparative test of antihypertensive effects of N-diethylaminoethyl reserpine (bietaserpine) and other similar drugs]. Saishin Igaku. 1971 Jan;26(1):145-53. Japanese. PubMed PMID: 5539259.

10: BERTHAUX P, NEUMAN M. [PHARMACOLOGICAL AND CLINICAL STUDY OF A NEW RESERPINE HYPOTENSIVE AGENTS N-DIETHYLAMINOETHYL RESERPINE (DL 152 OR BIETASERPINE)]. Arzneimittelforschung. 1964 Sep;14:1040-5. French. PubMed PMID: 14344158.

11: Berthaux P, Bourdarias H. [Treatment of arterial hypertension with a new reserpine derivative: bietaserpine]. Presse Med. 1967 May 20;75(24):1251-2. French. PubMed PMID: 6024179.

12: Marriq J. [Clinical trials of a new reserpine derivative: bietaserpine]. Mars Med. 1967;104(10):883-6. French. PubMed PMID: 5623932.

13: Ueda M, Doteuchi M, Matsuda S, Kawakami M, Tanaka H. [Depressor effect of N-diethylaminoethyl-reserpine (bietaserpine)]. Nihon Yakurigaku Zasshi. 1970;66(2):248-60. Japanese. PubMed PMID: 5464146.

14: Lafille C. [Comparison of the sedative effects of reserpine, syrosingopine and bietaserpine on the behavior of mice]. C R Seances Soc Biol Fil. 1967;161(12):2461-5. French. PubMed PMID: 4387158.