NEU-730

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527490

CAS#: 1622300-88-2

Description: NEU-730 is a novel inhibitor of TbrPDEB1, showing modest inhibition of T. brucei proliferation.

Chemical Structure

img
NEU-730
CAS# 1622300-88-2
Instruction

Theoretical Analysis

MedKoo Cat#: 527490
Name: NEU-730
CAS#: 1622300-88-2
Chemical Formula: C25H29NO5
Exact Mass: 423.20
Molecular Weight: 423.509
Elemental Analysis: C, 70.90; H, 6.90; N, 3.31; O, 18.89

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: NEU-730; NEU730; NEU 730

IUPAC/Chemical Name: cis-4-Cyano-4-[4-methoxy-3-(4-phenoxybutoxy)phenyl]-cyclohexanecarboxylic acid

InChi Key: OGVVVHXXDFPPNX-KJDSRRNHSA-N

InChi Code: InChI=1S/C25H29NO5/c1-29-22-10-9-20(25(18-26)13-11-19(12-14-25)24(27)28)17-23(22)31-16-6-5-15-30-21-7-3-2-4-8-21/h2-4,7-10,17,19H,5-6,11-16H2,1H3,(H,27,28)/t19-,25+

SMILES Code: O=C([C@H]1CC[C@](C2=CC=C(OC)C(OCCCCOC3=CC=CC=C3)=C2)(C#N)CC1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 423.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Schwedhelm C, Nimptsch K, Bub A, Pischon T, Linseisen J. Association between alcohol consumption and serum paraoxonase and arylesterase activities: a cross-sectional study within the Bavarian population. Br J Nutr. 2016 Feb 28;115(4):730-6. doi: 10.1017/S0007114515004985. Epub 2016 Jan 15. PubMed PMID: 26769660.

2: Duncan MA, Wu J, Neu MC, Orr MF; Centers for Disease Control and Prevention (CDC). Persons injured during acute chemical incidents—Hazardous Substances Emergency Events Surveillance, nine states, 1999-2008. MMWR Suppl. 2015 Apr 10;64(2):18-24. PubMed PMID: 25856534.

3: Hummel AS, Hertel C, Holzapfel WH, Franz CM. Antibiotic resistances of starter and probiotic strains of lactic acid bacteria. Appl Environ Microbiol. 2007 Feb;73(3):730-9. Epub 2006 Nov 22. PubMed PMID: 17122388; PubMed Central PMCID: PMC1800751.

4: Acosta D, Affolder T, Ahn MH, Akimoto T, Albrow MG, Ambrose D, Amerio S, Amidei D, Anastassov A, Anikeev K, Annovi A, Antos J, Aoki M, Apollinari G, Arguin JF, Arisawa T, Artikov A, Asakawa T, Ashmanskas W, Attal A, Azfar F, Azzi-Bacchetta P, Bacchetta N, Bachacou H, Badgett W, Bailey S, Barbaro-Galtieri A, Barker G, Barnes VE, Barnett BA, Baroiant S, Barone M, Bauer G, Bedeschi F, Behari S, Belforte S, Bell WH, Bellettini G, Bellinger J, Benjamin D, Beretvas A, Bhatti A, Binkley M, Bisello D, Bishai M, Blair RE, Blocker C, Bloom K, Blumenfeld B, Bocci A, Bodek A, Bolla G, Bolshov A, Booth PS, Bortoletto D, Boudreau J, Bourov S, Bromberg C, Brubaker E, Budagov J, Budd HS, Burkett K, Busetto G, Bussey P, Byrum KL, Cabrera S, Calafiura P, Campanelli M, Campbell M, Canepa A, Carlsmith D, Carron S, Carosi R, Casarsa M, Castro A, Catastini P, Cauz D, Cerri A, Cerri C, Cerrito L, Chapman J, Chen C, Chen YC, Chertok M, Chiarelli G, Chlachidze G, Chlebana F, Cho K, Chokheli D, Chu ML, Chung JY, Chung WH, Chung YS, Ciobanu CI, Ciocci MA, Clark AG, Clark D, Coca MN, Connolly A, Convery ME, Conway J, Cordelli M, Cortiana G, Cranshaw J, Culbertson R, Currat C, Cyr D, Dagenhart D, DaRonco S, D'Auria S, de Barbaro P, De Cecco S, De Lentdecker G, Dell'Agnello S, Dell'Orso M, Demers S, Demortier L, Deninno M, De Pedis D, Derwent PF, Dionisi C, Dittmann JR, Doksus P, Dominguez A, Donati S, D'Onofrio M, Dorigo T, Drollinger V, Ebina K, Eddy N, Ely R, Erbacher R, Erdmann M, Errede D, Errede S, Eusebi R, Fang HC, Farrington S, Fedorko I, Feild RG, Feindt M, Fernandez JP, Ferretti C, Field RD, Fiori I, Flanagan G, Flaugher B, Flores-Castillo LR, Foland A, Forrester S, Foster GW, Franklin M, Frisch H, Fujii Y, Furic I, Gaijar A, Gallas A, Gallinaro M, Galyardt J, Garcia-Sciveres M, Garfinkel AF, Gay C, Gerberich H, Gerchtein E, Gerdes DW, Giagu S, Giannetti P, Gibson A, Gibson K, Ginsburg C, Giolo K, Giordani M, Giurgiu G, Glagolev V, Glenzinski D, Gold M, Goldschmidt N, Goldstein D, Goldstein J, Gomez G, Gomez-Ceballos G, Goncharov M, Gorelov I, Goshaw AT, Gotra Y, Goulianos K, Gresele A, Grosso-Pilcher C, Guenther M, Guimaraes da Costa J, Haber C, Hahn K, Hahn SR, Halkiadakis E, Hall C, Handler R, Happacher F, Hara K, Hare M, Harr RF, Harris RM, Hartmann F, Hatakeyama K, Hauser J, Hays C, Hayward H, Heider E, Heinemann B, Heinrich J, Hennecke M, Herndon M, Hill C, Hirschbuehl D, Hocker A, Hoffman KD, Holloway A, Hou S, Houlden MA, Huang Y, Huffman BT, Hughes RE, Huston J, Ikado K, Incandela J, Introzzi G, Iori M, Ishizawa Y, Issever C, Ivanov A, Iwata Y, Iyutin B, James E, Jang D, Jarrell J, Jeans D, Jensen H, Jones M, Jun SY, Junk T, Kamon T, Kang J, Karagoz Unel M, Karchin PE, Kartal S, Kato Y, Kemp Y, Kephart R, Kerzel U, Khotilovich V, Kilminster B, Kim BJ, Kim DH, Kim HS, Kim JE, Kim MJ, Kim MS, Kim SB, Kim SH, Kim TH, Kim YK, King BT, Kirby M, Kirsch L, Klimenko S, Knuteson B, Ko BR, Kobayashi H, Koehn P, Kondo K, Konigsberg J, Kordas K, Korn A, Korytov A, Kotelnikov K, Kotwal AV, Kovalev A, Kraus J, Kravchenko I, Kreymer A, Kroll J, Kruse M, Krutelyov V, Kuhlmann SE, Kuznetsova N, Laasanen AT, Lai S, Lami S, Lammel S, Lancaster J, Lancaster M, Lander R, Lannon K, Lath A, Latino G, Lauhakangas R, Lazzizzera I, Le Y, Lecci C, LeCompte T, Lee J, Lee J, Lee SW, Leonardo N, Leone S, Lewis JD, Li K, Lin CS, Lindgren M, Liss TM, Litvintsev DO, Liu T, Liu Y, Lockyer NS, Loginov A, Loken J, Loreti M, Loverre P, Lucchesi D, Lukens P, Lyons L, Lys J, MacQueen D, Madrak R, Maeshima K, Maksimovic P, Malferrari L, Manca G, Marginean R, Martin A, Martin M, Martin V, Martinez M, Maruyama T, Matsunaga H, Mattson M, Mazzanti P, McFarland KS, McGivern D, McIntyre PM, McNamara P, McNulty R, Menzemer S, Menzione A, Merkel P, Mesropian C, Messina A, Meyer A, Miao T, Miladinovic N, Miller L, Miller R, Miller JS, Miquel R, Miscetti S, Mishina M, Mitselmakher G, Miyamoto A, Miyazaki Y, Moggi N, Moore R, Morello M, Moulik T, Mukherjee A, Mulhearn M, Muller T, Mumford R, Munar A, Murat P, Nachtman J, Nahn S, Nakamura I, Nakano I, Napier A, Napora R, Necula V, Niell F, Nielsen J, Nelson C, Nelson T, Neu C, Neubauer MS, Newman-Holmes C, Nicollerat AS, Nigmanov T, Nodulman L, Oesterberg K, Ogawa T, Oh S, Oh YD, Ohsugi T, Oishi R, Okusawa T, Oldeman R, Orava R, Orejudos W, Pagliarone C, Palmonari F, Paoletti R, Papadimitriou V, Pashapour S, Patrick J, Pauletta G, Paulini M, Pauly T, Paus C, Pellett D, Penzo A, Phillips TJ, Piacentino G, Piedra J, Pitts KT, Pompos A, Pondrom L, Pope G, Poukhov O, Prakoshyn F, Pratt T, Pronko A, Proudfoot J, Ptohos F, Punzi G, Rademacker J, Rakitine A, Rappoccio S, Ratnikov F, Ray H, Reichold A, Rekovic V, Renton P, Rescigno M, Rimondi F, Rinnert K, Ristori L, Robertson WJ, Robson A, Rodrigo T, Rolli S, Rosenson L, Roser R, Rossin R, Rott C, Russ J, Ruiz A, Ryan D, Saarikko H, Safonov A, St Denis R, Sakumoto WK, Saltzberg D, Sanchez C, Sansoni A, Santi L, Sarkar S, Sato K, Savard P, Savoy-Navarro A, Schemitz P, Schlabach P, Schmidt EE, Schmidt MP, Schmitt M, Scodellaro L, Scribano A, Scuri F, Sedov A, Seidel S, Seiya Y, Semeria F, Sexton-Kennedy L, Sfiligoi I, Shapiro MD, Shears T, Shepard PF, Shimojima M, Shochet M, Shon Y, Sidoti A, Siket M, Sill A, Sinervo P, Sisakyan A, Skiba A, Slaughter AJ, Sliwa K, Smith JR, Snider FD, Snihur R, Somalwar SV, Spalding J, Spezziga M, Spiegel L, Spinella F, Spiropulu M, Squillacioti P, Stadie H, Stelzer B, Stelzer-Chilton O, Strologas J, Stuart D, Sukhanov A, Sumorok K, Sun H, Suzuki T, Taffard A, Tafirout R, Takach SF, Takano H, Takashima R, Takeuchi Y, Takikawa K, Tamburello P, Tanaka M, Tanaka R, Tanimoto N, Tapprogge S, Tecchio M, Teng PK, Terashi K, Tesarek RJ, Tether S, Thom J, Thompson AS, Thomson E, Thurman-Keup R, Tipton P, Tiwari V, Tkaczyk S, Toback D, Tollefson K, Tonelli D, Tönnesmann M, Torre S, Torretta D, Trischuk W, Tseng J, Tsuchiya R, Tsuno S, Tsybychev D, Turini N, Turner M, Ukegawa F, Unverhau T, Uozumi S, Usynin D, Vacavant L, Vaiciulis T, Varganov A, Vataga E, Vejcik S 3rd, Velev G, Veramendi G, Vickey T, Vidal R, Vila I, Vilar R, Volobouev I, von der Mey M, Wagner RG, Wagner RL, Wagner W, Wallace N, Walter T, Wan Z, Wang MJ, Wang SM, Warburton A, Ward B, Waschke S, Waters D, Watts T, Weber M, Wester W, Whitehouse B, Wicklund AB, Wicklund E, Williams HH, Wilson P, Winer BL, Wittich P, Wolbers S, Wolter M, Worcester M, Worm S, Wright T, Wu X, Würthwein F, Wyatt A, Yagil A, Yamashita T, Yamamoto K, Yang UK, Yao W, Yeh GP, Yi K, Yoh J, Yoon P, Yorita K, Yoshida T, Yu I, Yu S, Yu Z, Yun JC, Zanello L, Zanetti A, Zaw I, Zetti F, Zhou J, Zsenei A, Zucchelli S. Observation of the narrow state X(3872)-->J/psipi+pi- in pp collisions at sqaure root of s=1.96 TeV. Phys Rev Lett. 2004 Aug 13;93(7):072001. Epub 2004 Aug 9. PubMed PMID: 15324226.

5: Jeschke M, Wels W, Dengler W, Imber R, Stöcklin E, Groner B. Targeted inhibition of tumor-cell growth by recombinant heregulin-toxin fusion proteins. Int J Cancer. 1995 Mar 3;60(5):730-9. PubMed PMID: 7860149.