WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561790

CAS#: 946507-08-0

Description: MT-7 is an inhibitor of tubulin polymerization.

Chemical Structure

CAS# 946507-08-0

Theoretical Analysis

MedKoo Cat#: 561790
Name: MT-7
CAS#: 946507-08-0
Chemical Formula: C22H17N3O2
Exact Mass: 355.1321
Molecular Weight: 355.39
Elemental Analysis: C, 74.35; H, 4.82; N, 11.82; O, 9.00

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MT-7; MT 7; MT7;

IUPAC/Chemical Name: 6-(4-Methoxy-benzyl)-6H-pyrido[2',1':2,3]imidazo[4,5-c]isoquinolin-5-one


InChi Code: InChI=1S/C22H17N3O2/c1-27-16-11-9-15(10-12-16)14-25-21-20(23-19-8-4-5-13-24(19)21)17-6-2-3-7-18(17)22(25)26/h2-13H,14H2,1H3

SMILES Code: O=C1N(CC2=CC=C(OC)C=C2)C(N3C(C=CC=C3)=N4)=C4C5=C1C=CC=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 355.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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1: Heijman J, Kirchner D, Kunze F, Chrétien EM, Michel-Reher MB, Voigt N, Knaut M, Michel MC, Ravens U, Dobrev D. Muscarinic type-1 receptors contribute to I(K,ACh) in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation. Int J Cardiol. 2017 Dec 22. pii: S0167-5273(17)37262-5. doi: 10.1016/j.ijcard.2017.12.050. [Epub ahead of print] PubMed PMID: 29290419.

2: Loo SE, Ryan MC, Zebarth BJ, Kuchta SH, Neilsen D, Mayer B. Use of δ(15)N and δ(18)O Values for Nitrate Source Identification under Irrigated Crops: A Cautionary Vadose Zone Tale. J Environ Qual. 2017 May;46(3):528-536. doi: 10.2134/jeq2016.08.0294. PubMed PMID: 28724099.

3: Slimani M, Miarka B, Briki W, Cheour F. Comparison of Mental Toughness and Power Test Performances in High-Level Kickboxers by Competitive Success. Asian J Sports Med. 2016 Mar 9;7(2):e30840. doi: 10.5812/asjsm.30840. eCollection 2016 Jun. PubMed PMID: 27625755; PubMed Central PMCID: PMC5003315.

4: Puente EI, De la Cruz L, Arenas I, Elias-Viñas D, Garcia DE. Voltage-Independent Inhibition of the Tetrodotoxin-Sensitive Sodium Currents by Oxotremorine and Angiotensin II in Rat Sympathetic Neurons. Mol Pharmacol. 2016 Apr;89(4):476-83. doi: 10.1124/mol.115.101931. Epub 2016 Feb 11. PubMed PMID: 26869400.

5: Franchi MV, Wilkinson DJ, Quinlan JI, Mitchell WK, Lund JN, Williams JP, Reeves ND, Smith K, Atherton PJ, Narici MV. Early structural remodeling and deuterium oxide-derived protein metabolic responses to eccentric and concentric loading in human skeletal muscle. Physiol Rep. 2015 Nov;3(11). pii: e12593. doi: 10.14814/phy2.12593. PubMed PMID: 26564061; PubMed Central PMCID: PMC4673627.

6: Pérez-Ramírez MB, Laville A, Tapia D, Duhne M, Lara-González E, Bargas J, Galarraga E. KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons. Neural Plast. 2015;2015:472676. doi: 10.1155/2015/472676. Epub 2015 May 31. PubMed PMID: 26113994; PubMed Central PMCID: PMC4465714.

7: Hirayama M, Ogata M, Kawamata T, Ishibashi H. Muscarinic receptor-mediated excitation of rat intracardiac ganglion neurons. Neuropharmacology. 2015 Aug;95:395-404. doi: 10.1016/j.neuropharm.2015.04.014. Epub 2015 Apr 29. PubMed PMID: 25937214.

8: Vietri MT, Riegler G, Pellino G, Molinari AM, Cioffi M. Arg72Pro polymorphism of p53 may predict poor response to medical treatment in ulcerative colitis. Ann Ital Chir. 2014 Nov-Dec;85(6):513-7. PubMed PMID: 25712892.

9: Hernández-Martínez R, Aceves JJ, Rueda-Orozco PE, Hernández-Flores T, Hernández-González O, Tapia D, Galarraga E, Bargas J. Muscarinic presynaptic modulation in GABAergic pallidal synapses of the rat. J Neurophysiol. 2015 Feb 1;113(3):796-807. doi: 10.1152/jn.00385.2014. Epub 2014 Nov 12. PubMed PMID: 25392165.

10: Catanzariti F, Cantoro U, Lacetera V, Muzzonigro G, Polito M. Testicular microlithiasis and dyspermia: is there any correlation? Arch Ital Urol Androl. 2014 Mar 28;86(1):20-2. doi: 10.4081/aiua.2014.1.20. PubMed PMID: 24704926.

11: Bartko SJ, Winters BD, Saksida LM, Bussey TJ. Different roles for M1 and M2 receptors within perirhinal cortex in object recognition and discrimination. Neurobiol Learn Mem. 2014 Apr;110:16-26. doi: 10.1016/j.nlm.2014.01.002. Epub 2014 Jan 24. PubMed PMID: 24462721.

12: Morrison AB, Goolsarran M, Rogers SL, Jha AP. Taming a wandering attention: short-form mindfulness training in student cohorts. Front Hum Neurosci. 2014 Jan 6;7:897. doi: 10.3389/fnhum.2013.00897. eCollection 2014 Jan 6. PubMed PMID: 24431994; PubMed Central PMCID: PMC3880932.

13: Khan RI, Yazawa T, Anisuzzaman AS, Semba S, Ma Y, Uwada J, Hayashi H, Suzuki Y, Ikeuchi H, Uchino M, Maemoto A, Muramatsu I, Taniguchi T. Activation of focal adhesion kinase via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial injury. Biochim Biophys Acta. 2014 Apr;1842(4):635-45. doi: 10.1016/j.bbadis.2013.12.007. Epub 2013 Dec 21. PubMed PMID: 24365239.

14: Morishima S, Anisuzzaman AS, Uwada J, Yoshiki H, Muramatsu I. Comparison of subcellular distribution and functions between exogenous and endogenous M1 muscarinic acetylcholine receptors. Life Sci. 2013 Jul 19;93(1):17-23. doi: 10.1016/j.lfs.2013.05.013. Epub 2013 May 30. PubMed PMID: 23727356.

15: Khan MR, Anisuzzaman AS, Semba S, Ma Y, Uwada J, Hayashi H, Suzuki Y, Takano T, Ikeuchi H, Uchino M, Maemoto A, Ushikubi F, Muramatsu I, Taniguchi T. M1 is a major subtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells. J Gastroenterol. 2013 Aug;48(8):885-96. doi: 10.1007/s00535-012-0718-5. Epub 2012 Dec 15. PubMed PMID: 23242454.

16: Sun XL, Bu PL, Liu JN, Wang X, Wu XN, Zhao LX. [Expression of SIRT1 in right auricle tissues and the relationship with oxidative stress in patients with atrial fibrillation]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Sep;28(9):972-4. Chinese. PubMed PMID: 22980663.

17: Valdezate S, Miranda C, Navarro A, Freitas AR, Cabrera JJ, Carrasco G, Coque TM, Jiménez-Romano E, Saéz-Nieto JA. Clonal outbreak of ST17 multidrug-resistant Enterococcus faecium harbouring an Inc18-like::Tn1546 plasmid in a haemo-oncology ward of a Spanish hospital. J Antimicrob Chemother. 2012 Apr;67(4):832-6. doi: 10.1093/jac/dkr545. Epub 2012 Jan 6. PubMed PMID: 22228676.

18: Odagaki Y, Toyoshima R. Muscarinic acetylcholine receptor-mediated activation of G(q) in rat brain membranes determined by guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding using an anti-G protein scintillation proximity assay. J Neural Transm (Vienna). 2012 May;119(5):525-32. doi: 10.1007/s00702-011-0742-2. Epub 2011 Nov 30. PubMed PMID: 22127550.

19: Bista P, Meuth SG, Kanyshkova T, Cerina M, Pawlowski M, Ehling P, Landgraf P, Borsotto M, Heurteaux C, Pape HC, Baukrowitz T, Budde T. Identification of the muscarinic pathway underlying cessation of sleep-related burst activity in rat thalamocortical relay neurons. Pflugers Arch. 2012 Jan;463(1):89-102. doi: 10.1007/s00424-011-1056-9. Epub 2011 Nov 15. PubMed PMID: 22083644.

20: Martino G, Puma C, Yu XH, Gilbert AK, Coupal M, Markoglou N, McIntosh FS, Perkins MN, Laird JM. The M1/M4 preferring agonist xanomeline is analgesic in rodent models of chronic inflammatory and neuropathic pain via central site of action. Pain. 2011 Dec;152(12):2852-60. doi: 10.1016/j.pain.2011.09.017. Epub 2011 Oct 22. PubMed PMID: 22018972.