SJA6017
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MedKoo CAT#: 555125

CAS#: 190274-53-4

Description: SJA6017, also known as Calpain Inhibitor VI, is a calpain inhibitor (calpain-1; IC50 = 7.5 nM) and m-calpain (calpain-2; IC50 = 78 nM). It also inhibits cathepsins B and L (IC50s = 15 and 1.6 nM, respectively). Treatment with SJA6017 reduces apoptotic cell death, preserves spinal cord tissue and improves functional outcome. Treating calpain-induced apoptosis with this agent may be a feasible therapeutic strategy for patients with spinal cord injury.


Price and Availability

Size Price Shipping out time Quantity
1mg USD 250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-06-02. Prices are subject to change without notice.

SJA6017, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555125
Name: SJA6017
CAS#: 190274-53-4
Chemical Formula: C17H25FN2O4S
Exact Mass: 372.1519
Molecular Weight: 372.4554
Elemental Analysis: C, 54.82; H, 6.77; F, 5.10; N, 7.52; O, 17.18; S, 8.61


Synonym: Calpain Inhibitor VI; Calpain Inhibitor 4; Calpain-In-4; SJA6017; SJA-6017; SJA 6017.

IUPAC/Chemical Name: (S)-2-((4-fluorophenyl)sulfonamido)-3-methyl-N-((S)-4-methyl-1-oxopentan-2-yl)butanamide

InChi Key: WSJWUIDLGZAXID-HOCLYGCPSA-N

InChi Code: InChI=1S/C17H25FN2O4S/c1-11(2)9-14(10-21)19-17(22)16(12(3)4)20-25(23,24)15-7-5-13(18)6-8-15/h5-8,10-12,14,16,20H,9H2,1-4H3,(H,19,22)/t14-,16-/m0/s1

SMILES Code: FC1=CC=C(C=C1)S(N[C@@H](C(C)C)C(N[C@H](C=O)CC(C)C)=O)(=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Akdemir O, Uçankale M, Karaoğlan A, Barut S, Sağmanligil A, Bilguvar K, Cirakoğlu B, Sahan E, Colak A. Therapeutic efficacy of SJA6017, a calpain inhibitor, in rat spinal cord injury. J Clin Neurosci. 2008 Oct;15(10):1130-6. doi: 10.1016/j.jocn.2007.08.011. Epub 2008 Jul 24. PubMed PMID: 18656362.

2: Biswas S, Harris F, Singh J, Phoenix DA. The in vitro retardation of porcine cataractogenesis by the calpain inhibitor, SJA6017. Mol Cell Biochem. 2004 Jun;261(1-2):169-73. PubMed PMID: 15362500.

3: Inoue J, Nakamura M, Cui YS, Sakai Y, Sakai O, Hill JR, Wang KK, Yuen PW. Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor. J Med Chem. 2003 Feb 27;46(5):868-71. PubMed PMID: 12593666.

4: Kupina NC, Nath R, Bernath EE, Inoue J, Mitsuyoshi A, Yuen PW, Wang KK, Hall ED. The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury. J Neurotrauma. 2001 Nov;18(11):1229-40. PubMed PMID: 11721741.

5: Tamada Y, Fukiage C, Mizutani K, Yamaguchi M, Nakamura Y, Azuma M, Shearer TR. Calpain inhibitor, SJA6017, reduces the rate of formation of selenite cataract in rats. Curr Eye Res. 2001 Apr;22(4):280-5. PubMed PMID: 11462167.

6: Fukiage C, Azuma M, Nakamura Y, Tamada Y, Nakamura M, Shearer TR. SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: amelioration of cataract in cultured rat lenses. Biochim Biophys Acta. 1997 Oct 24;1361(3):304-12. PubMed PMID: 9375805.