Frequentin
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MedKoo CAT#: 329897

CAS#: 29119-03-7

Description: Frequentin is an antibiotic originally isolated from P. frequentans that is active against bacteria (MICs = 300 and 200 µg/ml for S. aureus and B. subtilis, respectively) and fungi

Chemical Structure

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Frequentin
CAS# 29119-03-7
Instruction

Theoretical Analysis

MedKoo Cat#: 329897
Name: Frequentin
CAS#: 29119-03-7
Chemical Formula: C14H20O4
Exact Mass: 252.14
Molecular Weight: 252.310
Elemental Analysis: C, 66.65; H, 7.99; O, 25.36

Price and Availability

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1mg USD 550
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Synonym: Frequentin;

IUPAC/Chemical Name: 6-(1,3-heptadien-1-yl)-3,4-dihydroxy-2-oxo-cyclohexanecarboxaldehyde

InChi Key: MHZVWXOKIRZLCJ-YTXTXJHMSA-N

InChi Code: InChI=1S/C14H20O4/c1-2-3-4-5-6-7-10-8-12(16)14(18)13(17)11(10)9-15/h4-7,9-12,14,16,18H,2-3,8H2,1H3/b5-4+,7-6+

SMILES Code: O=CC1C(C(O)C(O)CC1/C=C/C=C/CCC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 252.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhang Y, Wang R, Song H, Huang G, Yi J, Zheng Y, Wang J, Chen L. Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer. Cancer Lett. 2011 Apr 1;303(1):21-8. doi: 10.1016/j.canlet.2010.12.011. Epub 2011 Jan 20. PubMed PMID: 21255913.

2: Yamaji K, Hashidoko Y, Fukushi Y, Tahara S. Chemical response of Picea glehnii seed-epiphytic Penicillium species to Pythium vexans under in vitro competitive conditions for mycelial growth. J Chem Ecol. 2005 Apr;31(4):805-17. PubMed PMID: 16124252.

3: Peyvandi F, Lak M, Mannucci PM. Factor XI deficiency in Iranians: its clinical manifestations in comparison with those of classic hemophilia. Haematologica. 2002 May;87(5):512-4. PubMed PMID: 12010665.

4: Moss MO. Reaction of 6-aminopenicillanic acid with frequentin. Experientia. 1964 Nov 15;20(11):605-6. PubMed PMID: 4955257.

5: CURTIS PJ, DUNCANSON LA. A structural relationship between frequentin and palitantin. Biochem J. 1952 May;51(2):276-8. PubMed PMID: 14944587; PubMed Central PMCID: PMC1197835.

6: CURTIS PJ, HEMMING HG, SMITH WK. Frequentin; an antibiotic produced by some strains of Penicillium frequentans Westling. Nature. 1951 Apr 7;167(4249):557-8. PubMed PMID: 14826842.