WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561785
Description: 6-Alkynyl-fucose is a widely used fucosylation probe. It acts by strongly inhibiting fucosylation and GDP-fucose synthetase FX and halting hepatoma invasion.
MedKoo Cat#: 561785
Chemical Formula: C7H10O5
Exact Mass: 174.0528
Molecular Weight: 174.15
Elemental Analysis: C, 48.28; H, 5.79; O, 45.93
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: 6-Alkynyl-fucose; 6-Alk-Fuc;
IUPAC/Chemical Name: (3S,4R,5S,6S)-6-ethynyltetrahydro-2H-pyran-2,3,4,5-tetraol
InChi Key: CZNHMTJHTGBOTL-DVEMRHSHSA-N
InChi Code: InChI=1S/C7H10O5/c1-2-3-4(8)5(9)6(10)7(11)12-3/h1,3-11H/t3-,4+,5+,6-,7?/m0/s1
SMILES Code: O[C@@H]1[C@H](C#C)OC(O)[C@@H](O)[C@@H]1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 174.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Kizuka Y, Nakano M, Yamaguchi Y, Nakajima K, Oka R, Sato K, Ren CT, Hsu TL, Wong CH, Taniguchi N. An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3. Cell Chem Biol. 2017 Dec 21;24(12):1467-1478.e5. doi: 10.1016/j.chembiol.2017.08.023. Epub 2017 Oct 12. PubMed PMID: 29033318.