Hexythiazox

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571468

CAS#: 78587-05-0

Description: Hexythiazox is an insecticide targeting mites.

Chemical Structure

Hexythiazox

CAS# 78587-05-0

Instruction

Theoretical Analysis

MedKoo Cat#: 571468
Name: Hexythiazox
CAS#: 78587-05-0
Chemical Formula: C17H21ClN2O2S
Exact Mass: 352.10
Molecular Weight: 352.880
Elemental Analysis: C, 57.86; H, 6.00; Cl, 10.05; N, 7.94; O, 9.07; S, 9.09

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 215
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Hexythizox; Calibre; Cesar; Nissorun; Matacar; Ordoval

IUPAC/Chemical Name: 3-Thiazolidinecarboxamide, 5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-, (4R,5R)-rel-

InChi Key: XGWIJUOSCAQSSV-ABAIWWIYSA-N

InChi Code: InChI=1S/C17H21ClN2O2S/c1-11-15(12-7-9-13(18)10-8-12)23-17(22)20(11)16(21)19-14-5-3-2-4-6-14/h7-11,14-15H,2-6H2,1H3,(H,19,21)/t11-,15+/m1/s1

SMILES Code: O=C(N1C(S[C@H](C2=CC=C(Cl)C=C2)[C@H]1C)=O)NC3CCCCC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 352.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Demaeght P, Osborne EJ, Odman-Naresh J, Grbić M, Nauen R, Merzendorfer H, Clark RM, Van Leeuwen T. High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticae. Insect Biochem Mol Biol. 2014 Aug;51:52-61. doi: 10.1016/j.ibmb.2014.05.004. Epub 2014 May 22. PubMed PMID: 24859419; PubMed Central PMCID: PMC4124130.

2: Yorulmaz Salman S, Ay R. Effect of hexythiazox and spiromesifen resistance on the life cycle of the predatory mite Neoseiulus californicus (Acari: Phytoseiidae). Exp Appl Acarol. 2014 Oct;64(2):245-52. doi: 10.1007/s10493-014-9817-8. Epub 2014 Apr 29. PubMed PMID: 24777359.

3: Khajvand T, Chaichi MJ, Colagar AH. Sensitive assay of hexythiazox residue in citrus fruits using gold nanoparticles-catalysed luminol-H2O2 chemiluminescence. Food Chem. 2015 Apr 15;173:514-20. doi: 10.1016/j.foodchem.2014.10.015. Epub 2014 Oct 18. PubMed PMID: 25466053.

4: Saber AN, Malhat FM, Badawy HM, Barakat DA. Dissipation dynamic, residue distribution and processing factor of hexythiazox in strawberry fruits under open field condition. Food Chem. 2016 Apr 1;196:1108-16. doi: 10.1016/j.foodchem.2015.10.052. Epub 2015 Oct 22. PubMed PMID: 26593595.

5: Mandal S, Joardar S, Das S, Bhattacharyya A. Photodegradation of hexythiazox in different solvent systems under the influence of ultraviolet light and sunlight in the presence of TiO2, H2O2, and KNO3 and identification of the photometabolites. J Agric Food Chem. 2011 Nov 9;59(21):11727-34. doi: 10.1021/jf202144p. Epub 2011 Oct 19. PubMed PMID: 21967247.

6: Asahara M, Uesugi R, Osakabe M. Linkage between one of the polygenic hexythiazox resistance genes and an etoxazole resistance gene in the twospotted spider mite (Acari: Tetranychidae). J Econ Entomol. 2008 Oct;101(5):1704-10. PubMed PMID: 18950055.

7: Campos FJ, Omoto C. [Stability of Brevipalpus phoenicis (Geijskes) (Acari: Tenuipalpidae) resistance to hexythiazox in citrus groves]. Neotrop Entomol. 2006 Nov-Dec;35(6):840-8. Portuguese. PubMed PMID: 17273718.

8: Ventura-Gayete JF, Armenta S, Garrigues S, Morales-Rubio A, de la Guardia M. Multicommutation-NIR determination of Hexythiazox in pesticide formulations. Talanta. 2006 Feb 28;68(5):1700-6. doi: 10.1016/j.talanta.2005.08.025. Epub 2005 Sep 15. PubMed PMID: 18970517.

9: Campos FJ, Omoto C. Resistance to hexythiazox in Brevipalpus phoenicis (Acari: Tenuipalpidae) from Brazilian citrus. Exp Appl Acarol. 2002;26(3-4):243-51. PubMed PMID: 12537296.

10: Bi JL, Niu ZM, Yu L, Toscano NC. Resistance status of the carmine spider mite, Tetranychus cinnabarinus and the twospotted spider mite, Tetranychus urticae to selected acaricides on strawberries. Insect Sci. 2016 Feb;23(1):88-93. doi: 10.1111/1744-7917.12190. Epub 2015 Jan 29. PubMed PMID: 25409919.

11: Martini X, Kincy N, Nansen C. Quantitative impact assessment of spray coverage and pest behavior on contact pesticide performance. Pest Manag Sci. 2012 Nov;68(11):1471-7. doi: 10.1002/ps.3330. Epub 2012 Jul 13. PubMed PMID: 22807174.

12: Tang X, Zhang Y, Wu Q, Xie W, Wang S. Stage-Specific Expression of Resistance to Different Acaricides in Four Field Populations of Tetranychus urticae (Acari: Tetranychidae). J Econ Entomol. 2014 Oct 1;107(5):1900-7. doi: 10.1603/EC14064. PubMed PMID: 26309280.

13: Nakajima T, Tsuruoka Y, Kanda M, Hayashi H, Hashimoto T, Matsushima Y, Yoshikawa S, Nagano C, Okutomi Y, Takano I. Determination and surveillance of nine acaricides and one metabolite in honey by liquid chromatography-tandem mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(7):1099-104. doi: 10.1080/19440049.2015.1050460. Epub 2015 Jun 8. PubMed PMID: 25967980.

14: Niell S, Jesús F, Pérez C, Mendoza Y, Díaz R, Franco J, Cesio V, Heinzen H. QuEChERS Adaptability for the Analysis of Pesticide Residues in Beehive Products Seeking the Development of an Agroecosystem Sustainability Monitor. J Agric Food Chem. 2015 May 13;63(18):4484-92. doi: 10.1021/acs.jafc.5b00795. Epub 2015 Apr 24. PubMed PMID: 25880394.

15: Van Leeuwen T, Tirry L, Yamamoto A, Nauen R, Dermauw W. The economic importance of acaricides in the control of phytophagous mites and an update on recent acaricide mode of action research. Pestic Biochem Physiol. 2015 Jun;121:12-21. doi: 10.1016/j.pestbp.2014.12.009. Epub 2014 Dec 12. Review. PubMed PMID: 26047107.

16: Li Y, Yang N, Wei X, Ling Y, Yang X, Wang Q. Evaluation of etoxazole against insects and acari in vegetables in China. J Insect Sci. 2014;14:104. doi: 10.1673/031.014.104. PubMed PMID: 25199415.

17: Masiá A, Vásquez K, Campo J, Picó Y. Assessment of two extraction methods to determine pesticides in soils, sediments and sludges. Application to the Túria River Basin. J Chromatogr A. 2015 Jan 23;1378:19-31. doi: 10.1016/j.chroma.2014.11.079. Epub 2014 Dec 18. PubMed PMID: 25573188.

18: Yorulmaz-Salman S, Ay R. Determination of the inheritance, cross-resistance and detoxifying enzyme levels of a laboratory-selected, spiromesifen-resistant population of the predatory mite Neoseiulus californicus (Acari: Phytoseiidae). Pest Manag Sci. 2014 May;70(5):819-26. doi: 10.1002/ps.3623. Epub 2013 Aug 30. PubMed PMID: 23907738.

19: Belenguer V, Martinez-Capel F, Masiá A, Picó Y. Patterns of presence and concentration of pesticides in fish and waters of the Júcar River (Eastern Spain). J Hazard Mater. 2014 Jan 30;265:271-9. doi: 10.1016/j.jhazmat.2013.11.016. Epub 2013 Nov 16. PubMed PMID: 24315814.

20: Lira AC, Zanardi OZ, Beloti VH, Bordini GP, Yamamoto PT, Parra JR, Carvalho GA. Lethal and Sublethal Impacts of Acaricides on Tamarixia radiata (Hemiptera: Eulophidae), an Important Ectoparasitoid of Diaphorina citri (Hemiptera: Liviidae). J Econ Entomol. 2015 Oct;108(5):2278-88. doi: 10.1093/jee/tov189. Epub 2015 Jul 3. PubMed PMID: 26453716.

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