Proquazone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584194

CAS#: 22760-18-5

Description: Proquazone is a nonsteroidal anti-inflammatory drug.


Chemical Structure

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Proquazone
CAS# 22760-18-5

Theoretical Analysis

MedKoo Cat#: 584194
Name: Proquazone
CAS#: 22760-18-5
Chemical Formula: C18H18N2O
Exact Mass: 278.14
Molecular Weight: 278.355
Elemental Analysis: C, 77.67; H, 6.52; N, 10.06; O, 5.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Arthrex; Biarison; Proquazona; Proquazonum; Proquazone

IUPAC/Chemical Name: 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-

InChi Key: JTIGKVIOEQASGT-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3

SMILES Code: O=C1N(C(C)C)C2=C(C=CC(C)=C2)C(C3=CC=CC=C3)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 278.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mäkäräinen L, Ylikorkala O. Menstrual blood loss in dysmenorrhoea: effects of proquazone and indomethacin. Br J Obstet Gynaecol. 1983 Jun;90(6):570-2. PubMed PMID: 6134549.

2: von Orelli J, Leuenberger H. Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution. Int J Pharm. 2004 Dec 9;287(1-2):135-45. PubMed PMID: 15541920.

3: Roos A, Hinderling PH. Protein binding and erythrocyte partitioning of the antirheumatic proquazone. J Pharm Sci. 1981 Mar;70(3):252-7. PubMed PMID: 7264886.

4: Ohnhaus EE. The effect of antacid and food on the absorption of proquazone (Biarison) in man. Int J Clin Pharmacol Ther Toxicol. 1980 Mar;18(3):136-9. PubMed PMID: 7380586.

5: Ruotsi A, Vainio U. Treatment of acute gouty arthritis with proquazone and indomethacin. A comparative, double-blind trial. Scand J Rheumatol Suppl. 1978;(21):15-7. PubMed PMID: 356235.

6: Johansson EA, Niemi KM, Ranki A. Modification of lymphocyte subsets in Jessner's lymphocytic infiltration of the skin during proquazone treatment. Dermatologica. 1988;176(2):70-5. PubMed PMID: 3371522.

7: Akçil E, Yavuz G, Koçak M. Effects of inflammation and antiinflammatory treatment on serum trace elements concentrations. Biol Trace Elem Res. 2003 Summer;93(1-3):95-104. PubMed PMID: 12835494.

8: Ruotsi A, Skrifvars B. A long-term double-blind comparative study on proquazone (Biarison) and ibuprofen in rheumatoid arthritis. Scand J Rheumatol Suppl. 1978;(21):28-32. PubMed PMID: 356239.

9: Serry MM. Proquazone ('Biarison') in osteoarthritis of the knee: a double-blind, dose comparison trial. Pharmatherapeutica. 1980;2(5):323-9. PubMed PMID: 7001491.

10: Gábor M, Rázga Z. Effects of non-steroidal antiphlogistics on mouse ear oedema induced with dithranol. Acta Physiol Hung. 1990;75(4):287-91. PubMed PMID: 2075824.

11: Hassan EM, Gazy AA, Abdel-Hay MH, Belal TS. High-performance liquid chromatographic determination of proquazone and its m-hydroxy metabolite in spiked human plasma and urine. J AOAC Int. 2007 Jul-Aug;90(4):971-6. PubMed PMID: 17760334.

12: Mertz DP. [Ankylosing spondylitis. Pathogenesis and therapy]. Fortschr Med. 1981 Mar 19;99(11):394-8. German. PubMed PMID: 7227933.

13: Bragstad A. A comparative, double-blind trial with proquazone and naproxen in the treatment of rheumatoid arthritis. Scand J Rheumatol Suppl. 1978;(21):33-5. PubMed PMID: 356240.

14: Welling PG, Tse FL. Food interactions affecting the absorption of analgesic and anti-inflammatory agents. Drug Nutr Interact. 1983;2(3):153-68. Review. PubMed PMID: 6381014.

15: Gábor M, Rázga Z. Influence of nonsteroidal antiphlogistics on mouse ear inflammation induced with croton oil. Arch Int Pharmacodyn Ther. 1989 May-Jun;299:241-6. PubMed PMID: 2774767.

16: Nissilä M, Kajander A. Proquazone (Biarison) and indomethacin (Indocid) in the treatment of ankylosing spondylitis. Two comparative, clinical, double-blind studies. Scand J Rheumatol Suppl. 1978;(21):36-9. PubMed PMID: 356241.

17: Brewer EJ, Giannini EH, Baum J, Fink CW, Hanson V, Jacobs JC, Schaller JG. Proquazone (Biarsan) in the treatment of juvenile rheumatoid arthritis. A segment I study. J Rheumatol. 1982 Jan-Feb;9(1):135-9. PubMed PMID: 7086771.

18: Forbes JA, White RW, White EH, Hughes MK. An evaluation of the analgesic efficacy of proquazone and aspirin in postoperative dental pain. J Clin Pharmacol. 1980 Jul;20(7):465-74. PubMed PMID: 7000855.

19: Franz JM, Gaillard A, Maibach HI, Schweitzer A. Percutaneous absorption of griseofulvin and proquazone in the rat and in isolated human skin. Arch Dermatol Res. 1981;271(3):275-82. PubMed PMID: 6975603.

20: Andersen RB, Halskov O. A double-blind clinical comparison of proquazone and naproxen in the treatment of patients with symptoms of lumbar nerve root compression syndrome. Scand J Rheumatol Suppl. 1978;(21):18-20. PubMed PMID: 356236.