KRP-109

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561765

CAS#: 1275996-50-3

Description: KRP-109 is a neutrophil elastase (NE) inhibitor. It acts by decreasing expression of TGF-ß Signal Related Genes.

Chemical Structure

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KRP-109
CAS# 1275996-50-3
Instruction

Theoretical Analysis

MedKoo Cat#: 561765
Name: KRP-109
CAS#: 1275996-50-3
Chemical Formula: C26H30N4O7
Exact Mass: 510.21
Molecular Weight: 510.540
Elemental Analysis: C, 61.17; H, 5.92; N, 10.97; O, 21.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: KRP-109; KRP 109; KRP109;

IUPAC/Chemical Name: 2-[2-(3-Dimethylamino-pyrrolidin-1-yl)-pyridin-3-yl]-5-ethyl-7-methoxy-benzo[d][1,3]oxazin-4-one Maleate

InChi Key: YLFBWXUNSRKFNI-BTJKTKAUSA-N

InChi Code: InChI=1S/C22H26N4O3.C4H4O4/c1-5-14-11-16(28-4)12-18-19(14)22(27)29-21(24-18)17-7-6-9-23-20(17)26-10-8-15(13-26)25(2)3;5-3(6)1-2-4(7)8/h6-7,9,11-12,15H,5,8,10,13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code: O=C1C2=C(CC)C=C(OC)C=C2N=C(C3=CC=CN=C3N4CC(N(C)C)CC4)O1.O=C(O)/C=C\C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 510.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chillappagari S, Müller C, Mahavadi P, Guenther A, Nährlich L, Rosenblum J, Rubin BK, Henke MO. A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation. J Cyst Fibros. 2016 May;15(3):325-31. doi: 10.1016/j.jcf.2015.10.008. Epub 2015 Oct 30. PubMed PMID: 26526358.

2: Yamada K, Yanagihara K, Araki N, Harada Y, Morinaga Y, Izumikawa K, Kakeya H, Yamamoto Y, Hasegawa H, Kohno S, Kamihira S. In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia. Pulm Pharmacol Ther. 2011 Dec;24(6):660-5. doi: 10.1016/j.pupt.2011.08.001. Epub 2011 Aug 16. PubMed PMID: 21864700.