Camylofin Hydrochloride

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MedKoo CAT#: 571448

CAS#: 5892-41-1 (HCl)

Description: Camylofin HCl is an antispasmodic used in labor treatment. It is also used to deliver drug therapy for ulcerative colinitis.

Chemical Structure

Camylofin Hydrochloride
CAS# 5892-41-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 571448
Name: Camylofin Hydrochloride
CAS#: 5892-41-1 (HCl)
Chemical Formula: C19H34Cl2N2O2
Exact Mass:
Molecular Weight: 393.39
Elemental Analysis: C, 58.01; H, 8.71; Cl, 18.02; N, 7.12; O, 8.13

Price and Availability

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1.0g USD 170.0 2 Weeks
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Related CAS #: 5892-41-1 (HCl)   54-30-8 (free base)  

Synonym: Camylofin Hydrochloride; Camylofin HCl; Avocan; Belosin; Acamylophenine hydrochloride; Acamylophenine HCl

IUPAC/Chemical Name: Benzeneacetic acid, alpha-((2-(diethylamino)ethyl)amino)-, 3-methylbutyl ester, 2HCl (9CI)


InChi Code: InChI=1S/C19H32N2O2.2ClH/c1-5-21(6-2)14-13-20-18(17-10-8-7-9-11-17)19(22)23-15-12-16(3)4;;/h7-11,16,18,20H,5-6,12-15H2,1-4H3;2*1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 393.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sarbhjit K, S K B, Parmjit K, Surinder B. To compare the effect of camylofin dihydrochloride (anafortin) with combination of valethamate bromide (epidosin) and hyoscine butyl-N-bormide (buscopan) on cervical dilation. J Clin Diagn Res. 2013 Sep;7(9):1897-9. doi: 10.7860/JCDR/2013/6231.3345. Epub 2013 Jul 22. PubMed PMID: 24179892; PubMed Central PMCID: PMC3809631.

2: Rohwer AC, Khondowe O, Young T. Antispasmodics for labour. Cochrane Database Syst Rev. 2013 Jun 5;(6):CD009243. doi: 10.1002/14651858.CD009243.pub3. Review. PubMed PMID: 23737030.

3: Elbarbry FA, Mabrouk MM, El-Dawy MA. Determination of the analgesic components of Spasmomigraine tablet by liquid chromatography with ultraviolet detection. J AOAC Int. 2007 Jan-Feb;90(1):94-101. PubMed PMID: 17373440.

4: Rohwer AC, Khondowe O, Young T. Antispasmodics for labour. Cochrane Database Syst Rev. 2012 Aug 15;(8):CD009243. doi: 10.1002/14651858.CD009243.pub2. Review. PubMed PMID: 22895986.

5: Dubey R, Dubey R, Omrey P, Vyas SP, Jain SK. Development and characterization of colon specific drug delivery system bearing 5-ASA and Camylofine dihydrochloride for the treatment of ulcerative colitis. J Drug Target. 2010 Sep;18(8):589-601. doi: 10.3109/10611860903572933. PubMed PMID: 20088681.

6: Schvartsman S, Schvartsman C, Barsanti C. Camylofin intoxication reversed by naloxone. Lancet. 1988 Nov 26;2(8622):1246. PubMed PMID: 2903969.

7: Gupta C. Use of anafortan intravenous injection for treatment of colicky pain. J Indian Med Assoc. 2000 Aug;98(8):479, 482. PubMed PMID: 11294338.

8: PILZ A. [Clinical experience with a new spasmolytic (avacan)]. Wien Med Wochenschr. 1955 May 21;105(20-21):438-9. German. PubMed PMID: 14397388.

9: STOLL HG. [Clinical experiences with avacan in urological diseases]. Medizinische. 1952 Sep 1;20(35-36):1125-7. Undetermined Language. PubMed PMID: 12992412.

10: HASSELBACHER K. [Cystometric studies after administration of avacan]. Arztl Forsch. 1959 Feb 10;13(2):I/94-6. German. PubMed PMID: 13626684.

11: HILLER J, STRAUSS E. [Effect of avacan on peristalsis of upper intestinal tract and on gastric secretion]. Arzneimittelforschung. 1953 Jun;3(6):282-4. Undetermined Language. PubMed PMID: 13081479.

12: REHSTEINER HP. [Comparative study on the labor-analgesic effect of Vendal and Centralgin-Avacan]. Ther Umsch. 1962 Aug;19:348-53. German. PubMed PMID: 14491125.

13: PEZOLD FA. [Spasmolysis (Clinical experience with a new spamolytic Avacan)]. Dtsch Med Wochenschr. 1951 Apr 6;76(14):479-81. Undetermined Language. PubMed PMID: 14831432.

14: SIELAFF HJ. [Comparative experimental studies on the effect of spasmolytics and ganglion-blocking substances (atropin, avacan, pendiomid, buscopan, banthine) on motility of the human small intestine]. Z Gesamte Exp Med. 1953;120(6):599-612. Undetermined Language. PubMed PMID: 13103235.

15: MURANO T, YAMANE K. A study of metabolism of isoamyl alpha-[N-(beta-diethylamino-ethyl)]-aminophenylacetate (avacan). Jpn J Pharmacol. 1956 Mar;5(2):122-31. PubMed PMID: 13331655.

16: BLOMER H, SCHIMERT G. [The effect of a new spasmolytic (Avacan) on the coronary vessels]. Dtsch Med Wochenschr. 1951 Apr 6;76(14):477-81. Undetermined Language. PubMed PMID: 14831431.

17: Auclair JM, Anton JP, Bellocq J, Zylberberg B. [Study of the action of the association of glyceric ether of guaiacol and camylofine on the dilatation of the cervix during the labor]. Rev Fr Gynecol Obstet. 1970 Sep;65(9):523-8. French. PubMed PMID: 5466471.

18: Crombez E, van den Bossche W, De Moerloose P. Gas-chromatographic determination of camylofine dihydrochloride in tablets and suppositories. J Chromatogr. 1976 Feb 4;117(1):161-6. PubMed PMID: 1249147.

19: JANN R. [Experience with the spasmolytic avacan in obstetrics]. Ther Umsch. 1954 Jul;11(4):80-2. Undetermined Language. PubMed PMID: 13187427.

20: ASHOLTER C. [Acceleration of delivery by Avacan]. Medizinische. 1953 Sep 5;36:1164-6. Undetermined Language. PubMed PMID: 13086308.