AAT-008
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561745

CAS#: 847727-81-5

Description: AAT-008 is an antagonist for the PGE2 receptor EP4.


Chemical Structure

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AAT-008
CAS# 847727-81-5

Theoretical Analysis

MedKoo Cat#: 561745
Name: AAT-008
CAS#: 847727-81-5
Chemical Formula: C21H16ClFN2O4
Exact Mass: 414.0783
Molecular Weight: 414.81
Elemental Analysis: C, 60.81; H, 3.89; Cl, 8.55; F, 4.58; N, 6.75; O, 15.43

Price and Availability

Size Price Availability Quantity
5.0mg USD 295.0 2 Weeks
10.0mg USD 495.0 2 Weeks
25.0mg USD 950.0 2 Weeks
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Synonym: AAT-008; AAT 008; AAT008;

IUPAC/Chemical Name: 4-[(1S)-1-[[[5-Chloro-2-(3-fluorophenoxy)-3-pyridinyl]carbonyl]amino]ethyl]-benzoic acid

InChi Key: FKXDPPYCCKCVCW-LBPRGKRZSA-N

InChi Code: InChI=1S/C21H16ClFN2O4/c1-12(13-5-7-14(8-6-13)21(27)28)25-19(26)18-9-15(22)11-24-20(18)29-17-4-2-3-16(23)10-17/h2-12H,1H3,(H,25,26)(H,27,28)/t12-/m0/s1

SMILES Code: O=C(O)C1=CC=C([C@@H](NC(C2=CC(Cl)=CN=C2OC3=CC=CC(F)=C3)=O)C)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certificate of Analysis:

Safety Data Sheet (SDS):

Preparing Stock Solutions

The following data is based on the product molecular weight 414.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Okumura Y, Yamagishi T, Nukui S, Nakao K. Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1186-1192. doi: 10.1016/j.bmcl.2017.01.067. Epub 2017 Jan 25. PubMed PMID: 28169162.

AAT-008

5.0mg / USD 295.0