UC-1728
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MedKoo CAT#: 555121

CAS#: 948304-40-3

Description: UC-1728, also known as t-TUCB, is a soluble epoxide hydrolase inhibitor. t-TUCB alleviates liver fibrosis and portal pressure in carbon tetrachloride-induced cirrhosis in rats. UC-1728 minimizes ischemia-reperfusion-induced cardiac damage in normal, hypertensive, and diabetic rats.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 120 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 750 Same day
200mg USD 1450 Same day
Inquire bulk and customized quantity

Pricing updated 2020-10-30. Prices are subject to change without notice.

UC-1728, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555121
Name: UC-1728
CAS#: 948304-40-3
Chemical Formula: C21H21F3N2O5
Exact Mass: 438.1403
Molecular Weight: 438.4032
Elemental Analysis: C, 57.53; H, 4.83; F, 13.00; N, 6.39; O, 18.25


Synonym: UC-1728; UC 1728; UC1728; t-TUCB.

IUPAC/Chemical Name: 4-(((1r,4r)-4-(3-(4-(trifluoromethoxy)phenyl)ureido)cyclohexyl)oxy)benzoic acid

InChi Key: XDVFKCZZXOGEMN-CZIWCDLHSA-N

InChi Code: InChI=1S/C21H21F3N2O5/c22-21(23,24)31-18-11-5-15(6-12-18)26-20(29)25-14-3-9-17(10-4-14)30-16-7-1-13(2-8-16)19(27)28/h1-2,5-8,11-12,14,17H,3-4,9-10H2,(H,27,28)(H2,25,26,29)/t14-,17-

SMILES Code: FC(F)(F)OC(C=C1)=CC=C1NC(N[C@@H](CC2)CC[C@H]2OC3=CC=C(C(O)=O)C=C3)=O


Technical Data

Appearance:
Solid powder

Purity:
>99% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Guedes AGP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hwang SH, Morisseau C, Hammock BD. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. J Vet Pharmacol Ther. 2017 Oct 25. doi: 10.1111/jvp.12463. [Epub ahead of print] PubMed PMID: 29067696.

2: Zhang CH, Zheng L, Gui L, Lin JY, Zhu YM, Deng WS, Luo M. Soluble epoxide hydrolase inhibition with t-TUCB alleviates liver fibrosis and portal pressure in carbon tetrachloride-induced cirrhosis in rats. Clin Res Hepatol Gastroenterol. 2017 Oct 11. pii: S2210-7401(17)30187-0. doi: 10.1016/j.clinre.2017.09.001. [Epub ahead of print] PubMed PMID: 29031875.

3: Deng W, Zhu Y, Lin J, Zheng L, Zhang C, Luo M. Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis. Prostaglandins Other Lipid Mediat. 2017 Jul;131:67-74. doi: 10.1016/j.prostaglandins.2017.08.004. Epub 2017 Aug 16. PubMed PMID: 28822809.

4: Huang Y, Qin J, Sun D, Jiang H, Zheng L, He Y, Gui L, Qian B, Zhang C, Luo M. Inhibition of soluble epoxide hydrolase reduces portal pressure by protecting mesenteric artery myogenic responses in cirrhotic rats. Prostaglandins Other Lipid Mediat. 2017 Jul;131:17-24. doi: 10.1016/j.prostaglandins.2017.03.007. Epub 2017 May 1. PubMed PMID: 28473204.

5: Kandhi S, Zhang B, Froogh G, Qin J, Alruwaili N, Le Y, Yang YM, Hwang SH, Hammock BD, Wolin MS, Huang A, Sun D. EETs promote hypoxic pulmonary vasoconstriction via constrictor prostanoids. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L350-L359. doi: 10.1152/ajplung.00038.2017. Epub 2017 Apr 27. PubMed PMID: 28450284; PubMed Central PMCID: PMC5582931.

6: Islam O, Patil P, Goswami SK, Razdan R, Inamdar MN, Rizwan M, Mathew J, Inceoglu B, Stephen Lee KS, Hwang SH, Hammock BD. Inhibitors of soluble epoxide hydrolase minimize ischemia-reperfusion-induced cardiac damage in normal, hypertensive, and diabetic rats. Cardiovasc Ther. 2017 Jun;35(3). doi: 10.1111/1755-5922.12259. PubMed PMID: 28296232; PubMed Central PMCID: PMC5597338.

7: Guedes A, Galuppo L, Hood D, Hwang SH, Morisseau C, Hammock BD. Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis. Equine Vet J. 2017 May;49(3):345-351. doi: 10.1111/evj.12603. Epub 2016 Aug 16. PubMed PMID: 27338788; PubMed Central PMCID: PMC5580818.

8: Qin J, Sun D, Jiang H, Kandhi S, Froogh G, Hwang SH, Hammock BD, Wolin MS, Thompson CI, Hintze TH, Huang A. Inhibition of soluble epoxide hydrolase increases coronary perfusion in mice. Physiol Rep. 2015 Jun;3(6). pii: e12427. doi: 10.14814/phy2.12427. PubMed PMID: 26071213; PubMed Central PMCID: PMC4510629.

9: Harris TR, Bettaieb A, Kodani S, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol. 2015 Jul 15;286(2):102-11. doi: 10.1016/j.taap.2015.03.022. Epub 2015 Mar 28. PubMed PMID: 25827057; PubMed Central PMCID: PMC4458210.

10: López-Vicario C, Alcaraz-Quiles J, García-Alonso V, Rius B, Hwang SH, Titos E, Lopategi A, Hammock BD, Arroyo V, Clària J. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):536-41. doi: 10.1073/pnas.1422590112. Epub 2014 Dec 30. PubMed PMID: 25550510; PubMed Central PMCID: PMC4299190.

11: Kim J, Yoon SP, Toews ML, Imig JD, Hwang SH, Hammock BD, Padanilam BJ. Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy. Am J Physiol Renal Physiol. 2015 Jan 15;308(2):F131-9. doi: 10.1152/ajprenal.00531.2014. Epub 2014 Nov 5. PubMed PMID: 25377915; PubMed Central PMCID: PMC4338924.

12: Wagner K, Yang J, Inceoglu B, Hammock BD. Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. J Pain. 2014 Sep;15(9):907-14. doi: 10.1016/j.jpain.2014.05.008. Epub 2014 Jun 9. PubMed PMID: 24924124; PubMed Central PMCID: PMC4150748.

13: Shrestha A, Krishnamurthy PT, Thomas P, Hammock BD, Hwang SH. Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats. J Pharm Pharmacol. 2014 Sep;66(9):1251-8. doi: 10.1111/jphp.12251. Epub 2014 Apr 2. PubMed PMID: 24697323; PubMed Central PMCID: PMC4134728.

14: Sun D, Cuevas AJ, Gotlinger K, Hwang SH, Hammock BD, Schwartzman ML, Huang A. Soluble epoxide hydrolase-dependent regulation of myogenic response and blood pressure. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1146-53. doi: 10.1152/ajpheart.00920.2013. Epub 2014 Feb 21. PubMed PMID: 24561863; PubMed Central PMCID: PMC3989753.

15: Guedes AG, Morisseau C, Sole A, Soares JH, Ulu A, Dong H, Hammock BD. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Vet Anaesth Analg. 2013 Jul;40(4):440-8. doi: 10.1111/vaa.12030. Epub 2013 Mar 7. PubMed PMID: 23463912; PubMed Central PMCID: PMC3956586.

16: Sanders WG, Morisseau C, Hammock BD, Cheung AK, Terry CM. Soluble epoxide hydrolase expression in a porcine model of arteriovenous graft stenosis and anti-inflammatory effects of a soluble epoxide hydrolase inhibitor. Am J Physiol Cell Physiol. 2012 Aug 1;303(3):C278-90. doi: 10.1152/ajpcell.00386.2011. Epub 2012 May 23. PubMed PMID: 22621785; PubMed Central PMCID: PMC3423029.

17: Wang L, Yang J, Guo L, Uyeminami D, Dong H, Hammock BD, Pinkerton KE. Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2012 May;46(5):614-22. doi: 10.1165/rcmb.2011-0359OC. Epub 2011 Dec 28. PubMed PMID: 22180869; PubMed Central PMCID: PMC3359909.