L594881 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527073

CAS#: 928621-15-2 (HCl)

Description: L594881, also known as 3',4'-Dichlorobenzamil or DCB, is an inhibitor of Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels. L594881 can inhibit Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels.

Chemical Structure

L594881 HCl
CAS# 928621-15-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 527073
Name: L594881 HCl
CAS#: 928621-15-2 (HCl)
Chemical Formula: C13H13Cl4N7O
Exact Mass: 422.9936
Molecular Weight: 425.095
Elemental Analysis: C, 36.73; H, 3.08; Cl, 33.36; N, 23.07; O, 3.76

Price and Availability

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5.0mg USD 550.0 2 Weeks
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Related CAS #: 928621-15-2 (HCl)   1166-01-4 (free base)    

Synonym: 3',4'-Dichlorobenzamil HCl; Dichlorobenzamil; L594881; L-594881; L 594881; DCB.

IUPAC/Chemical Name: [Amino-[(3,5-diamino-6-chloropyrazine-2-carbonyl)amino]methylidene]-[(3,4-dichlorophenyl)methyl]azanium chloride


InChi Code: InChI=1S/C13H12Cl3N7O.ClH/c14-6-2-1-5(3-7(6)15)4-20-13(19)23-12(24)8-10(17)22-11(18)9(16)21-8;/h1-3H,4H2,(H4,17,18,22)(H3,19,20,23,24);1H

SMILES Code: ClC1=CC=C(C/[NH+]=C(N)/NC(C2=NC(Cl)=C(N)N=C2N)=O)C=C1Cl.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 425.095 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sekizawa S, Bonham AC. Group I metabotropic glutamate receptors on second-order baroreceptor neurons are tonically activated and induce a Na+-Ca2+ exchange current. J Neurophysiol. 2006 Feb;95(2):882-92. Epub 2005 Sep 28. PubMed PMID: 16192328.

2: Lee K, Boden PR. Characterization of the inward current induced by metabotropic glutamate receptor stimulation in rat ventromedial hypothalamic neurones. J Physiol. 1997 Nov 1;504 ( Pt 3):649-63. PubMed PMID: 9401972; PubMed Central PMCID: PMC1159968.