Salbutamol Sulfate
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MedKoo CAT#: 527057

CAS#: 51022-70-9

Description: Salbutamol Sulfate is a short-acting beta-2 adrenergic agonist.


Chemical Structure

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Salbutamol Sulfate
CAS# 51022-70-9

Theoretical Analysis

MedKoo Cat#: 527057
Name: Salbutamol Sulfate
CAS#: 51022-70-9
Chemical Formula: C13H23NO7S
Exact Mass: 0.00
Molecular Weight: 337.390
Elemental Analysis: C, 46.28; H, 6.87; N, 4.15; O, 33.19; S, 9.50

Price and Availability

Size Price Availability Quantity
1g USD 350
5g USD 650
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Synonym: Salbutamol Sulfate; Salbutamol hemisulfate

IUPAC/Chemical Name: 4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol sulfuric acid salt

InChi Key: OVICLFZZVQVVFT-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H21NO3.H2O4S/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)

SMILES Code: OC1=CC=C(C(O)CNC(C)(C)C)C=C1CO.O=S(O)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.
In vitro activity: This study suggests that that salbutamol could be an effective adjuvant drug for the treatment of metastatic breast cancer. In IBH-6 and MDA-MB-231 cell lines, salbutamol significantly diminished cell migration. Also, salbutamol inhibited invasion of both breast cancer cell lines and enhanced adhesion to extracellular matrix. Salbutamol treatment was also able to decrease the expression of pro-metastatic genes in MDA-MB-231 cells. Reference: Curr Cancer Drug Targets. 2017;17(8):756-766. https://pubmed.ncbi.nlm.nih.gov/28359245/
In vivo activity: Salbutamol treatment significantly improved muscle strength and muscle coordination, and increased lean muscle mass in diabetic rats. Feret's diameter and cross-sectional area of GN muscle were increased by Salbutamol treatment, indicating the amelioration in diabetic rat muscle. Salbutamol treatment resulted in the restoration of perturbed metabolites, including histidine-to-tyrosine, phenylalanine-to-tyrosine, and glutamate-to-glutamine ratios and succinate, sarcosine, and 3-hydroxybutyrate in diabetic rats. Reference: Pharmaceutics. 2023 Aug 8;15(8):2101. https://pubmed.ncbi.nlm.nih.gov/37631314/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Water 67.0 198.58

Preparing Stock Solutions

The following data is based on the product molecular weight 337.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Mukherjee M, Cingolani E, Pritchard DI, Bosquillon C. Enhanced expression of Organic Cation Transporters in bronchial epithelial cell layers following insults associated with asthma - Impact on salbutamol transport. Eur J Pharm Sci. 2017 Aug 30;106:62-70. doi: 10.1016/j.ejps.2017.05.052. Epub 2017 May 23. PMID: 28549677. 2. Rivero EM, Piñero CP, Gargiulo L, Entschladen F, Zänker K, Bruzzone A, Lüthy IA. The β 2-Adrenergic Agonist Salbutamol Inhibits Migration, Invasion and Metastasis of the Human Breast Cancer MDA-MB- 231 Cell Line. Curr Cancer Drug Targets. 2017;17(8):756-766. doi: 10.2174/1568009617666170330151415. PMID: 28359245. 3. Kumar A, Prajapati P, Singh G, Kumar D, Mishra V, Kim SC, Raorane CJ, Raj V, Kushwaha S. Salbutamol Attenuates Diabetic Skeletal Muscle Atrophy by Reducing Oxidative Stress, Myostatin/GDF-8, and Pro-Inflammatory Cytokines in Rats. Pharmaceutics. 2023 Aug 8;15(8):2101. doi: 10.3390/pharmaceutics15082101. PMID: 37631314; PMCID: PMC10458056. 4. Cardoso-Sousa L, Aguiar EMG, Caixeta DC, Vilela DD, Costa DPD, Silva TL, Cunha TM, Faria PR, Espindola FS, Jardim AC, Vieira AA, Oliveira TL, Goulart LR, Sabino-Silva R. Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis. PLoS One. 2019 Sep 19;14(9):e0222575. doi: 10.1371/journal.pone.0222575. PMID: 31536570; PMCID: PMC6752759.
In vitro protocol: 1. Mukherjee M, Cingolani E, Pritchard DI, Bosquillon C. Enhanced expression of Organic Cation Transporters in bronchial epithelial cell layers following insults associated with asthma - Impact on salbutamol transport. Eur J Pharm Sci. 2017 Aug 30;106:62-70. doi: 10.1016/j.ejps.2017.05.052. Epub 2017 May 23. PMID: 28549677. 2. Rivero EM, Piñero CP, Gargiulo L, Entschladen F, Zänker K, Bruzzone A, Lüthy IA. The β 2-Adrenergic Agonist Salbutamol Inhibits Migration, Invasion and Metastasis of the Human Breast Cancer MDA-MB- 231 Cell Line. Curr Cancer Drug Targets. 2017;17(8):756-766. doi: 10.2174/1568009617666170330151415. PMID: 28359245.
In vivo protocol: 1. Kumar A, Prajapati P, Singh G, Kumar D, Mishra V, Kim SC, Raorane CJ, Raj V, Kushwaha S. Salbutamol Attenuates Diabetic Skeletal Muscle Atrophy by Reducing Oxidative Stress, Myostatin/GDF-8, and Pro-Inflammatory Cytokines in Rats. Pharmaceutics. 2023 Aug 8;15(8):2101. doi: 10.3390/pharmaceutics15082101. PMID: 37631314; PMCID: PMC10458056. 2. Cardoso-Sousa L, Aguiar EMG, Caixeta DC, Vilela DD, Costa DPD, Silva TL, Cunha TM, Faria PR, Espindola FS, Jardim AC, Vieira AA, Oliveira TL, Goulart LR, Sabino-Silva R. Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis. PLoS One. 2019 Sep 19;14(9):e0222575. doi: 10.1371/journal.pone.0222575. PMID: 31536570; PMCID: PMC6752759.

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