WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571426
Description: Capoamycin is an insotatracine antibiotic. It has been investigated for anti tumor properties.
MedKoo Cat#: 571426
Chemical Formula: C35H38O10
Exact Mass: 618.2465
Molecular Weight: 618.68
Elemental Analysis: C, 67.95; H, 6.19; O, 25.86
This product is not in stock, which may be available by custom synthesis.
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Synonym: Capoamycin; AC 54; AC54; AC-54
IUPAC/Chemical Name: (2S,3S,4S,6R)-4-hydroxy-2-methyl-6-((4aR,12bR)-4a,8,12b-trihydroxy-3-methyl-1,7,12-trioxo-1,4,4a,7,12,12b-hexahydrotetraphen-9-yl)tetrahydro-2H-pyran-3-yl (2E,4E)-deca-2,4-dienoate
InChi Key: MCNOFFKXBMHLAD-AVBRQSIPSA-N
InChi Code: InChI=1S/C35H38O10/c1-4-5-6-7-8-9-10-11-27(38)45-33-20(3)44-25(17-24(33)36)21-12-13-22-28(30(21)39)31(40)23-14-15-34(42)18-19(2)16-26(37)35(34,43)29(23)32(22)41/h8-16,20,24-25,33,36,39,42-43H,4-7,17-18H2,1-3H3/b9-8+,11-10+/t20-,24-,25+,33+,34-,35+/m0/s1
SMILES Code: CCCCC/C=C/C=C/C(O[C@@H]1[C@H](C)O[C@@H](C2=CC=C(C(C3=O)=C2O)C(C4=C3C=C[C@@]5(O)[C@@]4(O)C(C=C(C)C5)=O)=O)C[C@@H]1O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 618.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Hayakawa Y, Iwakiri T, Imamura K, Seto H, Otake N. Studies on the isotetracenone antibiotics. I. Capoamycin, a new antitumor antibiotic. J Antibiot (Tokyo). 1985 Jul;38(7):957-9. PubMed PMID: 3839783.
2: Sawa R, Matsuda N, Uchida T, Ikeda T, Sawa T, Naganawa H, Hamada M, Takeuchi T. Dioxamycin, a new benz[a]anthraquinone antibiotic. J Antibiot (Tokyo). 1991 Apr;44(4):396-402. PubMed PMID: 2032948.
3: Xin W, Ye X, Yu S, Lian XY, Zhang Z. New capoamycin-type antibiotics and polyene acids from marine Streptomyces fradiae PTZ0025. Mar Drugs. 2012 Oct 29;10(11):2388-402. doi: 10.3390/md10112388. PubMed PMID: 23203266; PubMed Central PMCID: PMC3509524.
4: Osda H. [Differentiation inducing compounds]. Tanpakushitsu Kakusan Koso. 1993 Aug;38(11):1791-9. Review. Japanese. PubMed PMID: 8210426.