Imidacloprid

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561712

CAS#: 105827-78-9

Description: Imidacloprid is an insect neurotoxin that acts by blocking nicotinic acetylcholine receptors and preventing acetylcholine from transmitting impulses between nerves.


Chemical Structure

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Imidacloprid
CAS# 105827-78-9

Theoretical Analysis

MedKoo Cat#: 561712
Name: Imidacloprid
CAS#: 105827-78-9
Chemical Formula: C9H10ClN5O2
Exact Mass: 255.05
Molecular Weight: 255.660
Elemental Analysis: C, 42.28; H, 3.94; Cl, 13.87; N, 27.39; O, 12.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Imidacloprid; Admire; Confidor; Provado;

IUPAC/Chemical Name: N-[1-(6-Chloro-pyridin-3-ylmethyl)-imidazolidin-2-ylidene]nitramide

InChi Key: YWTYJOPNNQFBPC-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H10ClN5O2/c10-8-2-1-7(5-12-8)6-14-4-3-11-9(14)13-15(16)17/h1-2,5H,3-4,6H2,(H,11,13)

SMILES Code: O=[N+](/N=C1NCCN\1CC2=CC=C(Cl)N=C2)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 255.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rust MK. The Biology and Ecology of Cat Fleas and Advancements in Their Pest Management: A Review. Insects. 2017 Oct 27;8(4). pii: E118. doi: 10.3390/insects8040118. Review. PubMed PMID: 29077073.

2: Sousa JCG, Ribeiro AR, Barbosa MO, Pereira MFR, Silva AMT. A review on environmental monitoring of water organic pollutants identified by EU guidelines. J Hazard Mater. 2018 Feb 15;344:146-162. doi: 10.1016/j.jhazmat.2017.09.058. Epub 2017 Oct 3. Review. PubMed PMID: 29032095.

3: Wood TJ, Goulson D. The environmental risks of neonicotinoid pesticides: a review of the evidence post 2013. Environ Sci Pollut Res Int. 2017 Jul;24(21):17285-17325. doi: 10.1007/s11356-017-9240-x. Epub 2017 Jun 7. Review. PubMed PMID: 28593544; PubMed Central PMCID: PMC5533829.

4: Gorito AM, Ribeiro AR, Almeida CMR, Silva AMT. A review on the application of constructed wetlands for the removal of priority substances and contaminants of emerging concern listed in recently launched EU legislation. Environ Pollut. 2017 Aug;227:428-443. doi: 10.1016/j.envpol.2017.04.060. Epub 2017 May 6. Review. PubMed PMID: 28486186.

5: De Long NE, Holloway AC. Early-life chemical exposures and risk of metabolic syndrome. Diabetes Metab Syndr Obes. 2017 Mar 21;10:101-109. doi: 10.2147/DMSO.S95296. eCollection 2017. Review. PubMed PMID: 28367067; PubMed Central PMCID: PMC5370400.

6: Hussain S, Hartley CJ, Shettigar M, Pandey G. Bacterial biodegradation of neonicotinoid pesticides in soil and water systems. FEMS Microbiol Lett. 2016 Dec;363(23). pii: fnw252. doi: 10.1093/femsle/fnw252. Epub 2016 Nov 9. Review. PubMed PMID: 28003337.

7: Carreck NL. A beekeeper's perspective on the neonicotinoid ban. Pest Manag Sci. 2017 Jul;73(7):1295-1298. doi: 10.1002/ps.4489. Epub 2017 Jan 30. Review. PubMed PMID: 27885794.

8: Schmuck R, Lewis G. Review of field and monitoring studies investigating the role of nitro-substituted neonicotinoid insecticides in the reported losses of honey bee colonies (Apis mellifera). Ecotoxicology. 2016 Nov;25(9):1617-1629. Epub 2016 Oct 5. Review. PubMed PMID: 27709399; PubMed Central PMCID: PMC5093195.

9: Casida JE, Durkin KA. Pesticide Chemical Research in Toxicology: Lessons from Nature. Chem Res Toxicol. 2017 Jan 17;30(1):94-104. doi: 10.1021/acs.chemrestox.6b00303. Epub 2016 Oct 7. Review. PubMed PMID: 27715053.

10: Yang C, Huang HP. Evidence-based veterinary dermatology: a review of published studies of treatments for Otodectes cynotis (ear mite) infestation in cats. Vet Dermatol. 2016 Aug;27(4):221-e56. doi: 10.1111/vde.12340. Epub 2016 Jun 20. Review. PubMed PMID: 27324289.

11: Barbosa MO, Moreira NF, Ribeiro AR, Pereira MF, Silva AM. Occurrence and removal of organic micropollutants: An overview of the watch list of EU Decision 2015/495. Water Res. 2016 May 1;94:257-79. doi: 10.1016/j.watres.2016.02.047. Epub 2016 Feb 23. Review. PubMed PMID: 26967909.

12: Sheets LP, Li AA, Minnema DJ, Collier RH, Creek MR, Peffer RC. A critical review of neonicotinoid insecticides for developmental neurotoxicity. Crit Rev Toxicol. 2016 Feb;46(2):153-90. doi: 10.3109/10408444.2015.1090948. Epub 2015 Oct 29. Review. PubMed PMID: 26513508; PubMed Central PMCID: PMC4732412.

13: Lundin O, Rundlöf M, Smith HG, Fries I, Bommarco R. Neonicotinoid Insecticides and Their Impacts on Bees: A Systematic Review of Research Approaches and Identification of Knowledge Gaps. PLoS One. 2015 Aug 27;10(8):e0136928. doi: 10.1371/journal.pone.0136928. eCollection 2015. Review. PubMed PMID: 26313444; PubMed Central PMCID: PMC4552548.

14: Bass C, Denholm I, Williamson MS, Nauen R. The global status of insect resistance to neonicotinoid insecticides. Pestic Biochem Physiol. 2015 Jun;121:78-87. doi: 10.1016/j.pestbp.2015.04.004. Epub 2015 Apr 28. Review. PubMed PMID: 26047114.

15: Jeschke P, Nauen R, Gutbrod O, Beck ME, Matthiesen S, Haas M, Velten R. Flupyradifurone (Sivanto™) and its novel butenolide pharmacophore: Structural considerations. Pestic Biochem Physiol. 2015 Jun;121:31-8. doi: 10.1016/j.pestbp.2014.10.011. Epub 2014 Oct 24. Review. PubMed PMID: 26047109.

16: Anderson JC, Dubetz C, Palace VP. Neonicotinoids in the Canadian aquatic environment: a literature review on current use products with a focus on fate, exposure, and biological effects. Sci Total Environ. 2015 Feb 1;505:409-22. doi: 10.1016/j.scitotenv.2014.09.090. Epub 2014 Oct 21. Review. PubMed PMID: 25461043.

17: Morrissey CA, Mineau P, Devries JH, Sanchez-Bayo F, Liess M, Cavallaro MC, Liber K. Neonicotinoid contamination of global surface waters and associated risk to aquatic invertebrates: a review. Environ Int. 2015 Jan;74:291-303. doi: 10.1016/j.envint.2014.10.024. Epub 2014 Nov 14. Review. PubMed PMID: 25454246.

18: Simon-Delso N, Amaral-Rogers V, Belzunces LP, Bonmatin JM, Chagnon M, Downs C, Furlan L, Gibbons DW, Giorio C, Girolami V, Goulson D, Kreutzweiser DP, Krupke CH, Liess M, Long E, McField M, Mineau P, Mitchell EA, Morrissey CA, Noome DA, Pisa L, Settele J, Stark JD, Tapparo A, Van Dyck H, Van Praagh J, Van der Sluijs JP, Whitehorn PR, Wiemers M. Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites. Environ Sci Pollut Res Int. 2015 Jan;22(1):5-34. doi: 10.1007/s11356-014-3470-y. Epub 2014 Sep 19. Review. PubMed PMID: 25233913; PubMed Central PMCID: PMC4284386.

19: Heath A, Levot GW. Parasiticide resistance in flies, lice and ticks in New Zealand and Australia: mechanisms, prevalence and prevention. N Z Vet J. 2015 Jul;63(4):199-210. doi: 10.1080/00480169.2014.960500. Epub 2015 Apr 22. Review. PubMed PMID: 25185062.

20: Wylie CE, Carbonell-Antoñanzas M, Aiassa E, Dhollander S, Zagmutt FJ, Brodbelt DC, Solano-Gallego L. A systematic review of the efficacy of prophylactic control measures for naturally occurring canine leishmaniosis. Part II: topically applied insecticide treatments and prophylactic medications. Prev Vet Med. 2014 Nov 1;117(1):19-27. doi: 10.1016/j.prevetmed.2014.06.016. Epub 2014 Jul 11. Review. Erratum in: Prev Vet Med. 2015 Jun 15;120(2):250-1. PubMed PMID: 25062787.