WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 527047
Description: ZINC08792229 is a novel SIRT1 inhibitor.
MedKoo Cat#: 527047
Chemical Formula: C30H22N4O3
Exact Mass: 486.1692
Molecular Weight: 486.531
Elemental Analysis: C, 74.06; H, 4.56; N, 11.52; O, 9.87
This product is not in stock, which may be available by custom synthesis.
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IUPAC/Chemical Name: N-[2-(1H-Indol-3-yl)-ethyl]-2-(8-oxo-8H-1,7b-diaza-benzo[e]acephenanthrylen-5-yloxy)-acetamide
InChi Key: ICNCBDPYLFXHAK-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H22N4O3/c35-25(31-11-9-17-14-33-24-8-4-3-5-19(17)24)16-37-18-13-23-21-10-12-32-28-22-7-2-1-6-20(22)27(26(21)28)30(36)29(23)34-15-18/h1-8,10,12-15,32-33H,9,11,16H2,(H,31,35)
SMILES Code: O=C(NCCC1=CNC2=C1C=CC=C2)COC(C=C34)=CN=C3C(C5=C(C=CC=C6)C6=C7NC=CC4=C75)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 486.531 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Sun Y, Zhou H, Zhu H, Leung SW. Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products. Sci Rep. 2016 Jan 25;6:19312. doi: 10.1038/srep19312. PubMed PMID: 26805727; PubMed Central PMCID: PMC4726279.