Balsalazide (free base)

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MedKoo CAT#: 527041

CAS#: 80573-04-2 (free base)

Description: Balsalazide (free base) is an anti-inflammatory agent for treatment of Inflammatory Bowel Disease.


Chemical Structure

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Balsalazide (free base)
CAS# 80573-04-2 (free base)

Theoretical Analysis

MedKoo Cat#: 527041
Name: Balsalazide (free base)
CAS#: 80573-04-2 (free base)
Chemical Formula: C17H15N3O6
Exact Mass: 357.10
Molecular Weight: 357.322
Elemental Analysis: C, 57.14; H, 4.23; N, 11.76; O, 26.86

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 80573-04-2 (free base)   82101-18-6 (salt)   150399-21-6 (Disodium)  

Synonym: Balsalazide (free base)

IUPAC/Chemical Name: (E)-5-[[[-4-(2-Carboxyethyl)aminocarbonyl]phenyl]azo]-2-hydroxybenzoic acid

InChi Key: IPOKCKJONYRRHP-FMQUCBEESA-N

InChi Code: InChI=1S/C17H15N3O6/c21-14-6-5-12(9-13(14)17(25)26)20-19-11-3-1-10(2-4-11)16(24)18-8-7-15(22)23/h1-6,9,21H,7-8H2,(H,18,24)(H,22,23)(H,25,26)/b20-19+

SMILES Code: O=C(O)C1=CC(/N=N/C2=CC=C(C(NCCC(O)=O)=O)C=C2)=CC=C1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 357.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kim SL, Kim SH, Park YR, Liu YC, Kim EM, Jeong HJ, Kim YN, Seo SY, Kim IH, Lee SO, Lee ST, Kim SW. Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-κB Activation. Mol Cancer Res. 2017 Feb;15(2):141-151. doi: 10.1158/1541-7786.MCR-16-0101. Epub 2016 Nov 14. PubMed PMID: 28108625.

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5: Kim HY, Kim SL, Park YR, Liu YC, Seo SY, Kim SH, Kim IH, Lee SO, Lee ST, Kim SW. Balsalazide Potentiates Parthenolide-Mediated Inhibition of Nuclear Factor-κB Signaling in HCT116 Human Colorectal Cancer Cells. Intest Res. 2015 Jul;13(3):233-41. doi: 10.5217/ir.2015.13.3.233. Epub 2015 Jun 9. PubMed PMID: 26130998; PubMed Central PMCID: PMC4479738.

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7: Dhaneshwar SS. Colon-specific prodrugs of 4-aminosalicylic acid for inflammatory bowel disease. World J Gastroenterol. 2014 Apr 7;20(13):3564-71. doi: 10.3748/wjg.v20.i13.3564. Review. PubMed PMID: 24707139; PubMed Central PMCID: PMC3974523.

8: Coman RM, Glover SC, Gjymishka A. Febrile pleuropericarditis, a potentially life-threatening adverse event of balsalazide--case report and literature review of the side effects of 5-aminosalicylates. Expert Rev Clin Immunol. 2014 May;10(5):667-75. doi: 10.1586/1744666X.2014.902313. Epub 2014 Apr 1. Review. PubMed PMID: 24689504.

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12: Huang HL, Lu PL, Lin CY, Chen YH, Kuo CH, Lin WR. Klebsiella pneumoniae bacteremia and renosplenic abscesses without intestinal symptoms as the initial manifestations of non-steroidal anti-inflammatory drug-induced colitis: a rare case report. BMC Gastroenterol. 2013 Sep 22;13:139. doi: 10.1186/1471-230X-13-139. PubMed PMID: 24053429; PubMed Central PMCID: PMC3849536.

13: Sonu I, Wong R, Rothenberg ME. 5-ASA induced recurrent myopericarditis and cardiac tamponade in a patient with ulcerative colitis. Dig Dis Sci. 2013 Aug;58(8):2148-50. doi: 10.1007/s10620-013-2566-4. Epub 2013 Jan 30. PubMed PMID: 23361575.

14: Kang SM, Jang YR, Yoon HH, Kim S, Kim EY, Ha SY, Park JW. A Case of Balsalazide-Induced Limited Form of Granulomatosis with Polyangiitis with Bronchiolitis Obliterans Organizing Pneumonia-like Variant in Ulcerative Colitis. Tuberc Respir Dis (Seoul). 2012 Mar;72(3):323-7. doi: 10.4046/trd.2012.72.3.323. Epub 2012 Mar 31. PubMed PMID: 23227073; PubMed Central PMCID: PMC3510283.

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16: Love BL, Miller AD. Extended-release mesalamine granules for ulcerative colitis. Ann Pharmacother. 2012 Nov;46(11):1529-36. doi: 10.1345/aph.1R171. Epub 2012 Oct 31. Review. PubMed PMID: 23115226.

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20: Ryan A, Wang CJ, Laurieri N, Westwood I, Sim E. Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases. Protein Cell. 2010 Aug;1(8):780-90. doi: 10.1007/s13238-010-0090-2. Epub 2010 Aug 28. PubMed PMID: 21203919; PubMed Central PMCID: PMC4875192.