INI-43

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527034

CAS#: 881046-01-1

Description: INI-43 is a novel Inhibitor of Nuclear Import-43, showing a significant cytotoxic effect on various cervical and oesophageal cancer cell lines by targeting Kpnß1.


Chemical Structure

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INI-43
CAS# 881046-01-1

Theoretical Analysis

MedKoo Cat#: 527034
Name: INI-43
CAS#: 881046-01-1
Chemical Formula: C22H23N7
Exact Mass: 385.20
Molecular Weight: 385.475
Elemental Analysis: C, 68.55; H, 6.01; N, 25.44

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: INI 43; INI43; INI-43

IUPAC/Chemical Name: 3-(1H-Benzimidazol-2-yl)-1-(3-dimethylaminopropyl)pyrrolo[5,4-b]quinoxalin-2-amine

InChi Key: LWPQQQAILAUWTI-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H23N7/c1-28(2)12-7-13-29-20(23)18(21-25-15-9-4-5-10-16(15)26-21)19-22(29)27-17-11-6-3-8-14(17)24-19/h3-6,8-11H,7,12-13,23H2,1-2H3,(H,25,26)

SMILES Code: NC1=C(C2=NC3=CC=CC=C3N2)C4=NC5=CC=CC=C5N=C4N1CCCN(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 385.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Stelma T, Leaner VD. KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells. Oncotarget. 2017 May 16;8(20):32833-32847. doi: 10.18632/oncotarget.15834. PubMed PMID: 28427184; PubMed Central PMCID: PMC5464831.

2: van der Watt PJ, Chi A, Stelma T, Stowell C, Strydom E, Carden S, Angus L, Hadley K, Lang D, Wei W, Birrer MJ, Trent JO, Leaner VD. Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic. Mol Cancer Ther. 2016 Apr;15(4):560-73. doi: 10.1158/1535-7163.MCT-15-0052. Epub 2016 Feb 1. PubMed PMID: 26832790.