Nequinate | CAS#13997-19-8

Nequinate
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527025

CAS#: 13997-19-8

Description: Nequinate is an anticoccidial agent, preventing coccidiosis and developing immunity against five different species of Eimeria.

Chemical Structure

Nequinate

CAS# 13997-19-8

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 527025
Name: Nequinate
CAS#: 13997-19-8
Chemical Formula: C22H23NO4
Exact Mass: 365.16
Molecular Weight: 365.429
Elemental Analysis: C, 72.31; H, 6.34; N, 3.83; O, 17.51

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 315
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Nequinate

IUPAC/Chemical Name: Methyl 6-butyl-4-oxo-7-phenylmethoxy-1H-quinoline-3-carboxylate

InChi Key: NNOPDLNHPOLRRE-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H23NO4/c1-3-4-10-16-11-17-19(23-13-18(21(17)24)22(25)26-2)12-20(16)27-14-15-8-6-5-7-9-15/h5-9,11-13H,3-4,10,14H2,1-2H3,(H,23,24)

SMILES Code: O=C(C1=CNC2=C(C=C(CCCC)C(OCC3=CC=CC=C3)=C2)C1=O)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections.
In vitro activity:	TBD
In vivo activity:	TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 365.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	TBD
In vitro protocol:	TBD
In vivo protocol:	TBD

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Clarke L, Moloney M, O'Mahony J, O'Kennedy R, Danaher M. Determination of 20 coccidiostats in milk, duck muscle and non-avian muscle tissue using UHPLC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(6):958-69. doi: 10.1080/19440049.2013.794306. Epub 2013 Jun 3. PubMed PMID: 23731083.

2: Nakajima T, Hayashi H, Sasamoto T, Kanda M, Kusano T, Matsushima Y, Kanai S, Takeba K, Nagayama T. [Determination of nequinate and buquinolate in livestock products using liquid chromatography-tandem mass spectrometry]. Shokuhin Eiseigaku Zasshi. 2011;52(3):178-82. PubMed PMID: 21720123.

3: Dousa M, Lemr K, Stránský Z. Determination of methylbenzoquate in premixes and animal feeds using liquid chromatography with fluorescence detection. J AOAC Int. 2005 May-Jun;88(3):673-8. PubMed PMID: 16001838.

4: Daugschies A, Gässlein U, Rommel M. Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials. Vet Parasitol. 1998 Apr 15;76(3):163-71. PubMed PMID: 9615950.

5: Chapman HD. Eimeria tenella, E. acervulina and E. maxima: studies on the development of resistance to diclazuril and other anticoccidial drugs in the chicken. Parasitology. 1989 Oct;99 Pt 2:189-92. PubMed PMID: 2556680.

6: Chapman HD. Sensitivity of field isolates of Eimeria tenella to anticoccidial drugs in the chicken. Res Vet Sci. 1989 Jul;47(1):125-8. PubMed PMID: 2549593.

7: Merson GH, Hill LA, Johnson SF. Determination of methyl benzoquate in poultry feedingstuffs using high-performance liquid chromatography. Analyst. 1985 Jul;110(7):761-4. PubMed PMID: 3880516.

8: Varewyck H, Peeters JE, Halen P, Lampo P, Bouquet Y. Influence of the anticoccidials clopidol/methylbenzoquate and robenidine on fertility and progeny of female rabbits. Br Vet J. 1984 Mar-Apr;140(2):202-6. PubMed PMID: 6586253.

9: Peeters JE, Geeroms R, Varewyck H, Bouquet Y, Lampo P, Halen P. Immunity and effect of clopidol/methyl benzoquate and robenidine before and after weaning on rabbit coccidiosis in the field. Res Vet Sci. 1983 Sep;35(2):211-6. PubMed PMID: 6356256.

10: Joyner LP, Catchpole J, Berrett S. Eimeria stiedai in rabbits: the demonstration of responses to chemotherapy. Res Vet Sci. 1983 Jan;34(1):64-7. PubMed PMID: 6132429.

11: Peeters JE, Geeroms R, Molderez J, Halen P. Activity of clopidol/methylbenzoquate, robenidine and salinomycin against hepatic coccidiosis in rabbits. Zentralbl Veterinarmed B. 1982 Apr;29(3):207-18. PubMed PMID: 6956190.

12: Mathis GF, McDougald LR. Drug responsiveness of field isolates of chicken Coccidia. Poult Sci. 1982 Jan;61(1):38-45. PubMed PMID: 7088782.

13: Kowalski LM, Reid WM. Effects of roxarsone on pigmentation and coccidiosis in broilers. Poult Sci. 1975 Sep;54(5):1544-9. PubMed PMID: 1187515.

14: Mitrovic M, Schildknecht EG. Lasalocid: resistance and cross-resistance studies in Eimeria tenella-infected chicks. Poult Sci. 1975 May;54(3):750-6. PubMed PMID: 1153374.

15: McLoughlin DK, Chute MB. Efficacy of nequinate against thirteen strains of Eimeria tenella and the development of a nequinate-resistant strain. Avian Dis. 1973 Oct-Dec;17(4):717-21. PubMed PMID: 4766564.

16: Cox PL. Collaborative study for the determination of nequinate in feeds. J Assoc Off Anal Chem. 1971 Jan;54(1):69-71. PubMed PMID: 5170699.

Your view history

Nequinate featured