RH-5849

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527015

CAS#: 112225-87-3

Description: RH-5849 is a novel Insect growth regulator, as potential insecticide to control olive fruit fly (Bactrocera oleae Rossi).

Chemical Structure

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RH-5849
CAS# 112225-87-3
Instruction

Theoretical Analysis

MedKoo Cat#: 527015
Name: RH-5849
CAS#: 112225-87-3
Chemical Formula: C18H20N2O2
Exact Mass: 296.15
Molecular Weight: 296.370
Elemental Analysis: C, 72.95; H, 6.80; N, 9.45; O, 10.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: RH-5849; RH 5849; RH5849

IUPAC/Chemical Name: 1,2-Dibenzoyl-1-tert-butylhydrazine

InChi Key: NISLLQUWIJASOV-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H20N2O2/c1-18(2,3)20(17(22)15-12-8-5-9-13-15)19-16(21)14-10-6-4-7-11-14/h4-13H,1-3H3,(H,19,21)

SMILES Code: CC(N(C(C1=CC=CC=C1)=O)NC(C2=CC=CC=C2)=O)(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 296.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Clements JS 2nd, Islam R, Sun B, Tong F, Gross AD, Bloomquist JR, Carlier PR. N'-mono- and N, N'-diacyl derivatives of benzyl and arylhydrazines as contact insecticides against adult Anopheles gambiae. Pestic Biochem Physiol. 2017 Nov;143:33-38. doi: 10.1016/j.pestbp.2017.10.001. Epub 2017 Oct 7. PubMed PMID: 29183608.

2: Li Z, Zhao X, Chen J, Wu Y, Zhang J, Zhang K, Hu D. Determination of RH-5849 and indoxacarb in rice straw, rice husk, brown rice and soil using liquid chromatography-tandem triple quadrupole mass spectrometry following extraction with QuEChERS method. Biomed Chromatogr. 2016 Oct;30(10):1625-31. doi: 10.1002/bmc.3732. Epub 2016 Apr 26. PubMed PMID: 27037908.

3: Yang ZB, Hu DY, Zeng S, Song BA. Novel hydrazone derivatives containing pyridine amide moiety: Design, synthesis, and insecticidal activity. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1161-4. doi: 10.1016/j.bmcl.2016.01.047. Epub 2016 Jan 18. PubMed PMID: 26832221.

4: Amor F, Christiaens O, Bengochea P, Medina P, Rougé P, Viñuela E, Smagghe G. Selectivity of diacylhydrazine insecticides to the predatory bug Orius laevigatus: in vivo and modelling/docking experiments. Pest Manag Sci. 2012 Dec;68(12):1586-94. doi: 10.1002/ps.3353. Epub 2012 Jul 3. PubMed PMID: 22761153.

5: Bengochea P, Christiaens O, Amor F, Viñuela E, Rougé P, Medina P, Smagghe G. Insect growth regulators as potential insecticides to control olive fruit fly (Bactrocera oleae Rossi): insect toxicity bioassays and molecular docking approach. Pest Manag Sci. 2013 Jan;69(1):27-34. doi: 10.1002/ps.3350. Epub 2012 Jun 22. PubMed PMID: 22730139.

6: Bengochea P, Christiaens O, Amor F, Viñuela E, Rougé P, Medina P, Smagghe G. Ecdysteroid receptor docking suggests that dibenzoylhydrazine-based insecticides are devoid of any deleterious effect on the parasitic wasp Psyttalia concolor (Hym. Braconidae). Pest Manag Sci. 2012 Jul;68(7):976-85. doi: 10.1002/ps.3274. Epub 2012 Mar 29. PubMed PMID: 22467436.

7: Qian M, Wu L, Zhang H, Xu M, Li R, Wang X, Sun C. Determination of 16 insect growth regulators in edible Chinese traditional herbs by liquid chromatography electrospray tandem mass spectrometry. Anal Bioanal Chem. 2012 Mar;402(7):2451-62. doi: 10.1007/s00216-011-5699-3. Epub 2012 Jan 20. PubMed PMID: 22271101.

8: Taghavi A, Nasir S, Pickhardt M, Heyny-von Haussen R, Mall G, Mandelkow E, Mandelkow EM, Schmidt B. N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands. J Alzheimers Dis. 2011;27(4):835-43. doi: 10.3233/JAD-2011-111238. PubMed PMID: 21891864.

9: Qian M, Zhang H, Wu L, Chen Z, Wang X. [Determination of five diacylhydrazine insecticide residues in welsh onion using high performance liquid chromatography-tandem mass spectrometry]. Se Pu. 2010 Sep;28(9):854-8. Chinese. PubMed PMID: 21171281.

10: Chaitanya RK, Sridevi P, Senthilkumaran B, Gupta AD. 20-Hydroxyecdysone regulation of H-fibroin gene in the stored grain pest Corcyra cephalonica, during the last instar larval development. Steroids. 2011 Jan;76(1-2):125-34. doi: 10.1016/j.steroids.2010.09.009. Epub 2010 Oct 27. PubMed PMID: 21034755.

11: Drummond CA, Vandock KP, Smith SL, Fioravanti CF. Cyclic 3', 5' guanosine monophosphate and larval midgut ecdysone 20-monooxygenase activity of the tobacco hornworm, Manduca sexta. Comp Biochem Physiol B Biochem Mol Biol. 2010 Sep;157(1):33-8. doi: 10.1016/j.cbpb.2010.04.017. Epub 2010 May 6. PubMed PMID: 20451652.

12: Mao CH, Wang KL, Wang ZW, Ou XM, Huang RQ, Bi FC, Wang QM. Synthesis and insecticidal evaluation of novel N'-tert-butyl-N'-substitutedbenzoyl-N-5-chloro-6-chromanecarbohydrazide derivatives. Bioorg Med Chem. 2008 Jan 1;16(1):488-94. Epub 2007 Sep 14. PubMed PMID: 17897833.

13: Davies L, Williams DR, Aguiar-Santana IA, Pedersen J, Turner PC, Rees HH. Expression and down-regulation of cytochrome P450 genes of the CYP4 family by ecdysteroid agonists in Spodoptera littoralis and Drosophila melanogaster. Insect Biochem Mol Biol. 2006 Oct;36(10):801-7. Epub 2006 Aug 23. PubMed PMID: 17027846.

14: Hami M, Taibi F, Smagghe G, Soltani-Mazouni N. Comparative toxicity of three ecdysone agonist insecticides against the Mediterranean flour moth. Commun Agric Appl Biol Sci. 2005;70(4):767-73. PubMed PMID: 16628915.

15: Löw P, Talián GC, Sass M. Up- and downregulated genes in muscles that undergo developmentally programmed cell death in the insect Manduca sexta. FEBS Lett. 2005 Sep 12;579(22):4943-8. PubMed PMID: 16122740.

16: Feng S, Kong Z, Wang X, Peng P, Zeng EY. Assessing the genotoxicity of imidacloprid and RH-5849 in human peripheral blood lymphocytes in vitro with comet assay and cytogenetic tests. Ecotoxicol Environ Saf. 2005 Jun;61(2):239-46. PubMed PMID: 15883095.

17: Beckage NE, Marion KM, Walton WE, Wirth MC, Tan FF. Comparative larvicidal toxicities of three ecdysone agonists on the mosquitoes Aedes aegypti, Culex quinquefasciatus, and Anopheles gambiae. Arch Insect Biochem Physiol. 2004 Nov;57(3):111-22. PubMed PMID: 15484259.

18: Feng S, Kong Z, Wang X, Zhao L, Peng P. Acute toxicity and genotoxicity of two novel pesticides on amphibian, Rana N. Hallowell. Chemosphere. 2004 Aug;56(5):457-63. PubMed PMID: 15212911.

19: Seth RK, Kaur JJ, Rao DK, Reynolds SE. Effects of larval exposure to sublethal concentrations of the ecdysteroid agonists RH-5849 and tebufenozide (RH-5992) on male reproductive physiology in Spodoptera litura. J Insect Physiol. 2004 Jun;50(6):505-17. PubMed PMID: 15183280.

20: Boukachabia A, Soltani-Mazouni N, Smagghe G, Soltani N. Comparative effects of some ecdysteroid agonists in mealworms: ecdysteroid amounts and protein analysis in developing ovaries under in vivo conditions. Commun Agric Appl Biol Sci. 2003;68(4 Pt A):307-12. PubMed PMID: 15149124.