CAPE
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561682

CAS#: 104594-70-9

Description: CAPE is an inhibitor of BAF. It works by activating latent HIV-1, inhibiting PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK), hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).


Chemical Structure

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CAPE
CAS# 104594-70-9

Theoretical Analysis

MedKoo Cat#: 561682
Name: CAPE
CAS#: 104594-70-9
Chemical Formula: C17H16O4
Exact Mass: 284.1049
Molecular Weight: 284.31
Elemental Analysis: C, 71.82; H, 5.67; O, 22.51

Price and Availability

Size Price Availability Quantity
100.0mg USD 245.0 2 Weeks
500.0mg USD 520.0 2 Weeks
1.0g USD 795.0 2 Weeks
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Synonym: CAPE; Caffeic Acid Phenethyl Ester; BAF-IN-C09; 2-Phenylethyl Caffeate; β-Phenylethyl Caffeate;

IUPAC/Chemical Name: 2-Phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

InChi Key: SWUARLUWKZWEBQ-VQHVLOKHSA-N

InChi Code: InChI=1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+

SMILES Code: O=C(OCCC1=CC=CC=C1)/C=C/C2=CC=C(O)C(O)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certificate of Analysis:

Safety Data Sheet (SDS):

Preparing Stock Solutions

The following data is based on the product molecular weight 284.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Cornara L, Biagi M, Xiao J, Burlando B. Therapeutic Properties of Bioactive Compounds from Different Honeybee Products. Front Pharmacol. 2017 Jun 28;8:412. doi: 10.3389/fphar.2017.00412. eCollection 2017. Review. PubMed PMID: 28701955; PubMed Central PMCID: PMC5487425.

2: Budisan L, Gulei D, Zanoaga OM, Irimie AI, Sergiu C, Braicu C, Gherman CD, Berindan-Neagoe I. Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer. Int J Mol Sci. 2017 Jun 1;18(6). pii: E1178. doi: 10.3390/ijms18061178. Review. PubMed PMID: 28587155; PubMed Central PMCID: PMC5486001.

3: Habtemariam S. Protective Effects of Caffeic Acid and the Alzheimer's Brain: An Update. Mini Rev Med Chem. 2017;17(8):667-674. doi: 10.2174/1389557516666161130100947. Review. PubMed PMID: 27903226.

4: Ma Y, Zhang JX, Liu YN, Ge A, Gu H, Zha WJ, Zeng XN, Huang M. Caffeic acid phenethyl ester alleviates asthma by regulating the airway microenvironment via the ROS-responsive MAPK/Akt pathway. Free Radic Biol Med. 2016 Dec;101:163-175. doi: 10.1016/j.freeradbiomed.2016.09.012. Epub 2016 Oct 13. Review. PubMed PMID: 27746262.

5: Yuksel S, Akyol S. The consumption of propolis and royal jelly in preventing upper respiratory tract infections and as dietary supplementation in children. J Intercult Ethnopharmacol. 2016 Mar 31;5(3):308-11. doi: 10.5455/jice.20160331064836. eCollection 2016 Jun-Aug. Review. PubMed PMID: 27366357; PubMed Central PMCID: PMC4927136.

6: Allameh Z, Salamzadeh J. Use of antioxidants in urinary tract infection. J Res Pharm Pract. 2016 Apr-Jun;5(2):79-85. doi: 10.4103/2279-042X.179567. Review. PubMed PMID: 27162800; PubMed Central PMCID: PMC4843588.

7: Akyol S, Gulec MA, Erdemli HK, Akyol O. Can propolis and caffeic acid phenethyl ester be promising agents against cyclophosphamide toxicity? J Intercult Ethnopharmacol. 2016 Jan 28;5(1):105-7. doi: 10.5455/jice.20160127024542. eCollection 2016 Jan-Feb. Review. PubMed PMID: 27069732; PubMed Central PMCID: PMC4805141.

8: Erdemli HK, Akyol S, Armutcu F, Gulec MA, Canbal M, Akyol O. Melatonin and caffeic acid phenethyl ester in the regulation of mitochondrial function and apoptosis: The basis for future medical approaches. Life Sci. 2016 Mar 1;148:305-12. doi: 10.1016/j.lfs.2016.01.026. Epub 2016 Jan 16. Review. PubMed PMID: 26784848.

9: Erdemli HK, Akyol S, Armutcu F, Akyol O. Antiviral properties of caffeic acid phenethyl ester and its potential application. J Intercult Ethnopharmacol. 2015 Oct-Dec;4(4):344-7. doi: 10.5455/jice.20151012013034. Epub 2015 Nov 5. Review. PubMed PMID: 26649239; PubMed Central PMCID: PMC4665029.

10: Akyol S, Akbas A, Butun I, Toktas M, Ozyurt H, Sahin S, Akyol O. Caffeic acid phenethyl ester as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads. J Intercult Ethnopharmacol. 2015 Apr-Jun;4(2):187-91. doi: 10.5455/jice.20150402062823. Epub 2015 Apr 3. Review. PubMed PMID: 26401405; PubMed Central PMCID: PMC4566781.

11: Kuo YY, Jim WT, Su LC, Chung CJ, Lin CY, Huo C, Tseng JC, Huang SH, Lai CJ, Chen BC, Wang BJ, Chan TM, Lin HP, Chang WS, Chang CR, Chuu CP. Caffeic Acid phenethyl ester is a potential therapeutic agent for oral cancer. Int J Mol Sci. 2015 May 12;16(5):10748-66. doi: 10.3390/ijms160510748. Review. PubMed PMID: 25984601; PubMed Central PMCID: PMC4463674.

12: Akyol S, Isik B, Altuntas A, Erden G, Cakmak O, Kurşunlu SF, Adam B, Akyol O. Future opportunities in preventing ototoxicity: Caffeic acid phenethyl ester may be a candidate (Review). Mol Med Rep. 2015 Sep;12(3):3231-5. doi: 10.3892/mmr.2015.3785. Epub 2015 May 14. Review. PubMed PMID: 25975288.

13: Murtaza G, Sajjad A, Mehmood Z, Shah SH, Siddiqi AR. Possible molecular targets for therapeutic applications of caffeic acid phenethyl ester in inflammation and cancer. J Food Drug Anal. 2015 Mar;23(1):11-18. doi: 10.1016/j.jfda.2014.06.001. Epub 2014 Aug 11. Review. PubMed PMID: 28911433.

14: Patel S. Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents. J Diet Suppl. 2016;13(3):245-68. doi: 10.3109/19390211.2015.1008614. Epub 2015 Feb 27. Review. PubMed PMID: 25723108.

15: Tolba MF, Omar HA, Azab SS, Khalifa AE, Abdel-Naim AB, Abdel-Rahman SZ. Caffeic Acid Phenethyl Ester: A Review of Its Antioxidant Activity, Protective Effects against Ischemia-reperfusion Injury and Drug Adverse Reactions. Crit Rev Food Sci Nutr. 2016 Oct 2;56(13):2183-90. doi: 10.1080/10408398.2013.821967. Review. PubMed PMID: 25365228.

16: Zhang P, Tang Y, Li NG, Zhu Y, Duan JA. Bioactivity and chemical synthesis of caffeic acid phenethyl ester and its derivatives. Molecules. 2014 Oct 13;19(10):16458-76. doi: 10.3390/molecules191016458. Review. PubMed PMID: 25314606.

17: Akyol S, Ugurcu V, Balci M, Gurel A, Erden G, Cakmak O, Akyol O. Caffeic acid phenethyl ester: its protective role against certain major eye diseases. J Ocul Pharmacol Ther. 2014 Nov;30(9):700-8. doi: 10.1089/jop.2014.0046. Epub 2014 Aug 6. Review. PubMed PMID: 25100535.

18: Akyol S, Ugurcu V, Altuntas A, Hasgul R, Cakmak O, Akyol O. Caffeic acid phenethyl ester as a protective agent against nephrotoxicity and/or oxidative kidney damage: a detailed systematic review. ScientificWorldJournal. 2014;2014:561971. doi: 10.1155/2014/561971. Epub 2014 Jun 3. Review. PubMed PMID: 25003138; PubMed Central PMCID: PMC4065767.

19: Murtaza G, Karim S, Akram MR, Khan SA, Azhar S, Mumtaz A, Bin Asad MH. Caffeic acid phenethyl ester and therapeutic potentials. Biomed Res Int. 2014;2014:145342. doi: 10.1155/2014/145342. Epub 2014 May 29. Review. PubMed PMID: 24971312; PubMed Central PMCID: PMC4058104.

20: Tolba MF, Azab SS, Khalifa AE, Abdel-Rahman SZ, Abdel-Naim AB. Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: a review on its anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects. IUBMB Life. 2013 Aug;65(8):699-709. doi: 10.1002/iub.1189. Epub 2013 Jul 11. Review. PubMed PMID: 23847089.

CAPE

100.0mg / USD 245.0