Cythioate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571409

CAS#: 115-93-5

Description: Cythioate is a cholinesterase inhibitor used as an insecticide.


Chemical Structure

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Cythioate
CAS# 115-93-5

Theoretical Analysis

MedKoo Cat#: 571409
Name: Cythioate
CAS#: 115-93-5
Chemical Formula: C8H12NO5PS2
Exact Mass: 296.99
Molecular Weight: 297.280
Elemental Analysis: C, 32.32; H, 4.07; N, 4.71; O, 26.91; P, 10.42; S, 21.57

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Cythoate; Proban; BRN 2148114

IUPAC/Chemical Name: O,O-Dimethyl O-(4-sulphamoylphenyl) thiophosphate

InChi Key: BSBSDQUZDZXGFN-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H12NO5PS2/c1-12-15(16,13-2)14-7-3-5-8(6-4-7)17(9,10)11/h3-6H,1-2H3,(H2,9,10,11)

SMILES Code: S=P(OC)(OC)OC1=CC=C(S(=O)(N)=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 297.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dryden MW. Differential activity of cythioate against female and male Ctenocephalides felis on cats. Am J Vet Res. 1992 May;53(5):801-2. PubMed PMID: 1524312.

2: Hazelwood JC, Stefan GE, Bowen JM. Motor unit irritability in Beagles Before and after exposure to cholinesterase inhibitors. Am J Vet Res. 1979 Jun;40(6):852-6. PubMed PMID: 89824.

3: Bowen PM, Caldwell NJ. Use of cythioate to control external parasites on cats and dogs. Vet Med Small Anim Clin. 1982 Jan;77(1):79-80. PubMed PMID: 7039075.

4: Crystal MM, DeMilo AB. Susceptibility of laboratory-reared northern fowl mites, Ornithonyssus sylviarum (Acari: Macronyssidae), to selected acaricides. Exp Appl Acarol. 1988 Jul;4(4):353-8. PubMed PMID: 3168660.

5: Zakson-Aiken M, Gregory LM, Shoop WL. Development of an assay for the screening of compounds against larvae of the cat flea (Siphonaptera: Pulicidae). J Med Entomol. 2000 Jul;37(4):571-4. PubMed PMID: 10916298.

6: Schenker R, Tinembart O, Humbert-Droz E, Cavaliero T, Yerly B. Comparative speed of kill between nitenpyram, fipronil, imidacloprid, selamectin and cythioate against adult Ctenocephalides felis (Bouché) on cats and dogs. Vet Parasitol. 2003 Mar 10;112(3):249-54. PubMed PMID: 12591200.

7: Zhao P, Baughman RG. O,O-Dimethyl O-(4-sulfamoylphen-yl) phospho-rothio-ate (cythio-ate). Acta Crystallogr Sect E Struct Rep Online. 2013 Jun 8;69(Pt 7):o1042. doi: 10.1107/S1600536813014724. eCollection 2013. PubMed PMID: 24046618; PubMed Central PMCID: PMC3772475.

8: Doval CP, Gupta I. Effect of cythioate on cholinesterase activity in erythrocytes and plasma and transaminase activity in serum of sheep and dogs. Indian J Exp Biol. 1976 Mar;14(2):193-4. PubMed PMID: 992748.

9: Lämmler G, Grüner D. Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 6. The filaricidal activity of organophosphorus compounds. Tropenmed Parasitol. 1975 Sep;26(3):359-69. PubMed PMID: 1189030.

10: Santora KA, Zakson-Aiken M, Rasa C, Shoop W. Development of a mouse model to determine the systemic activity of potential flea-control compounds. Vet Parasitol. 2002 Mar 20;104(3):257-64. PubMed PMID: 11812623.

11: Manson ER, Malynicz GL. The use of cythioate in the treatment of demodectic mange in the dog. Aust Vet J. 1969 Nov;45(11):533-4. PubMed PMID: 5393090.

12: Yarborough JH, Yarborough JH 3rd. A clinical evaluation of cythioate, a new oral systemic parasiticide for dogs. Vet Med Small Anim Clin. 1968 Jun;63(6):584-6. PubMed PMID: 5185598.

13: Smith HG Jr, Goulding RL. Toxicological aspects of three organophosphorus compounds (Cythioate, Famphur, and Fenthion) in the host-ectoparasite system. J Econ Entomol. 1970 Oct;63(5):1640-6. PubMed PMID: 5488792.