WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561674
CAS#: 903580-39-2 (HCl)
Description: PRX-07034 is a selective 5-HT6 receptor antagonist. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents. PRX-07034 is both a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist (≥100-fold selectivity for the 5-HT(6) receptor compared to 68 other GPCRs, ion channels, and transporters, except D(3) (Ki = 71 nM) and 5-HT(1B) (Ki = 260 nM) receptors. For cyclic AMP quantification, PRX-07034 demonstrated antagonist activity (IC(50) = 19 nM) without an effect on basal levels and did not show any agonist activity up to 10 μM. PRX-07034 at 1 and 3 mg/kg (but not 0.1 mg/kg) significantly enhanced delayed spontaneous alternation.
MedKoo Cat#: 561674
Name: PRX-07034 HCl
CAS#: 903580-39-2 (HCl)
Chemical Formula: C21H29Cl2N3O4S
Exact Mass: 489.1256
Molecular Weight: 490.44
Elemental Analysis: C, 51.43; H, 5.96; Cl, 14.46; N, 8.57; O, 13.05; S, 6.54
Related CAS #: 903580-16-5 (free base) 903580-39-2 (HCl)
Synonym: PRX-07034; PRX07034; PRX 07034; PRX-07034 HCl; PRX-07034 hydrochloride.
IUPAC/Chemical Name: N-[1-(5-Chloro-2,3-dimethoxyphenyl)ethyl]-2-methylsulfonyl-5-piperazin-1-ylaniline hydrochloride
InChi Key: PILCQJJJAFRKHO-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H28ClN3O4S.ClH/c1-14(17-11-15(22)12-19(28-2)21(17)29-3)24-18-13-16(25-9-7-23-8-10-25)5-6-20(18)30(4,26)27;/h5-6,11-14,23-24H,7-10H2,1-4H3;1H
SMILES Code: O=S(C1=CC=C(N2CCNCC2)C=C1NC(C3=CC(Cl)=CC(OC)=C3OC)C)(C)=O.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 490.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Abraham R, Nirogi R, Shinde A, Irupannanavar S. Low-dose prazosin in combination with 5-HT6 antagonist PRX-07034 has antipsychotic effects. Can J Physiol Pharmacol. 2015 Jan;93(1):13-21. doi: 10.1139/cjpp-2014-0254. PMID: 25429515.
2: Mohler EG, Baker PM, Gannon KS, Jones SS, Shacham S, Sweeney JA, Ragozzino ME. The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 2012 Apr;220(4):687-96. doi: 10.1007/s00213-011-2518-7. Epub 2011 Oct 12. PMID: 21989804; PMCID: PMC3636983.
3: Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology. 2008 Nov;55(6):1015-22. doi: 10.1016/j.neuropharm.2008.06.061. Epub 2008 Jul 4. PMID: 18655798.
4: Halford JC, Harrold JA, Boyland EJ, Lawton CL, Blundell JE. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity. Drugs. 2007;67(1):27-55. doi: 10.2165/00003495-200767010-00004. PMID: 17209663.
