PRX-07034 HCl

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MedKoo CAT#: 561674

CAS#: 903580-39-2 (HCl)

Description: PRX-07034 is a selective 5-HT6 receptor antagonist. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents. PRX-07034 is both a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist (≥100-fold selectivity for the 5-HT(6) receptor compared to 68 other GPCRs, ion channels, and transporters, except D(3) (Ki = 71 nM) and 5-HT(1B) (Ki = 260 nM) receptors. For cyclic AMP quantification, PRX-07034 demonstrated antagonist activity (IC(50) = 19 nM) without an effect on basal levels and did not show any agonist activity up to 10 μM. PRX-07034 at 1 and 3 mg/kg (but not 0.1 mg/kg) significantly enhanced delayed spontaneous alternation.

Chemical Structure

PRX-07034 HCl
CAS# 903580-39-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 561674
Name: PRX-07034 HCl
CAS#: 903580-39-2 (HCl)
Chemical Formula: C21H29Cl2N3O4S
Exact Mass: 489.1256
Molecular Weight: 490.44
Elemental Analysis: C, 51.43; H, 5.96; Cl, 14.46; N, 8.57; O, 13.05; S, 6.54

Price and Availability

Size Price Availability Quantity
50.0mg USD 450.0 2 Weeks
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 1950.0 2 Weeks
1.0g USD 2950.0 2 Weeks
2.0g USD 5250.0 2 Weeks
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Related CAS #: 903580-16-5 (free base)   903580-39-2 (HCl)    

Synonym: PRX-07034; PRX07034; PRX 07034; PRX-07034 HCl; PRX-07034 hydrochloride.

IUPAC/Chemical Name: N-[1-(5-Chloro-2,3-dimethoxyphenyl)ethyl]-2-methylsulfonyl-5-piperazin-1-ylaniline hydrochloride


InChi Code: InChI=1S/C21H28ClN3O4S.ClH/c1-14(17-11-15(22)12-19(28-2)21(17)29-3)24-18-13-16(25-9-7-23-8-10-25)5-6-20(18)30(4,26)27;/h5-6,11-14,23-24H,7-10H2,1-4H3;1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 490.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Abraham R, Nirogi R, Shinde A, Irupannanavar S. Low-dose prazosin in combination with 5-HT6 antagonist PRX-07034 has antipsychotic effects. Can J Physiol Pharmacol. 2015 Jan;93(1):13-21. doi: 10.1139/cjpp-2014-0254. PMID: 25429515.

2: Mohler EG, Baker PM, Gannon KS, Jones SS, Shacham S, Sweeney JA, Ragozzino ME. The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 2012 Apr;220(4):687-96. doi: 10.1007/s00213-011-2518-7. Epub 2011 Oct 12. PMID: 21989804; PMCID: PMC3636983.

3: Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology. 2008 Nov;55(6):1015-22. doi: 10.1016/j.neuropharm.2008.06.061. Epub 2008 Jul 4. PMID: 18655798.

4: Halford JC, Harrold JA, Boyland EJ, Lawton CL, Blundell JE. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity. Drugs. 2007;67(1):27-55. doi: 10.2165/00003495-200767010-00004. PMID: 17209663.

PRX-07034 HCl

10.0mg / Not available