6-Hydroxy-DL-DOPA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526591

CAS#: 21373-30-8

Description: 6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52, inhibiting proliferation of BRCA-deficient cancer cells in vitro, also inhibiting APE1.


Chemical Structure

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6-Hydroxy-DL-DOPA
CAS# 21373-30-8

Theoretical Analysis

MedKoo Cat#: 526591
Name: 6-Hydroxy-DL-DOPA
CAS#: 21373-30-8
Chemical Formula: C9H11NO5
Exact Mass: 213.0637
Molecular Weight: 213.189
Elemental Analysis: C, 50.71; H, 5.20; N, 6.57; O, 37.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 6-Hydroxy-DL-DOPA

IUPAC/Chemical Name: 2,5-Dihydroxy-DL-tyrosine

InChi Key: YLKRUSPZOTYMAT-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)

SMILES Code: NC(CC1=CC(O)=C(O)C=C1O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 213.189 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Chandramouly G, McDevitt S, Sullivan K, Kent T, Luz A, Glickman JF, Andrake M, Skorski T, Pomerantz RT. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol. 2015 Nov 19;22(11):1491-1504. doi: 10.1016/j.chembiol.2015.10.003. Epub 2015 Nov 5. PubMed PMID: 26548611; PubMed Central PMCID: PMC4701204.

2: Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM 3rd. Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One. 2009 Jun 1;4(6):e5740. doi: 10.1371/journal.pone.0005740. PubMed PMID: 19484131; PubMed Central PMCID: PMC2685009.