WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 526498
Description: Zolantidine dimaleate is a potent, selective, and brain penetrating H2 receptor antagonist.
MedKoo Cat#: 526498
Name: Zolantidine dimaleate
Chemical Formula: C30H35N3O9S
Exact Mass: 613.21
Molecular Weight: 613.68
Elemental Analysis: C, 58.72; H, 5.75; N, 6.85; O, 23.46; S, 5.22
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Zolantidine dimaleate
IUPAC/Chemical Name: N-[3-[3-(Piperidin-1-ylmethyl)phenoxy]propyl]-1,3-benzothiazol-2-amine dimaleate salt
InChi Key: IECBEVAUEBZJCF-SPIKMXEPSA-N
InChi Code: InChI=1S/C22H27N3OS.2C4H4O4/c1-4-13-25(14-5-1)17-18-8-6-9-19(16-18)26-15-7-12-23-22-24-20-10-2-3-11-21(20)27-22;2*5-3(6)1-2-4(7)8/h2-3,6,8-11,16H,1,4-5,7,12-15,17H2,(H,23,24);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
SMILES Code: O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.C1(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=CC=CC=C4S1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 613.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Hough LB, Nalwalk JW. Inhibition of morphine antinociception by centrally administered histamine H2 receptor antagonists. Eur J Pharmacol. 1992 Apr 29;215(1):69-74. PubMed PMID: 1355443.
2: Hough LB, Nalwalk JW, Battles AH. Zolantidine-induced attenuation of morphine antinociception in rhesus monkeys. Brain Res. 1990 Aug 27;526(1):153-5. PubMed PMID: 1981852.
3: Gogas KR, Hough LB, Eberle NB, Lyon RA, Glick SD, Ward SJ, Young RC, Parsons ME. A role for histamine and H2-receptors in opioid antinociception. J Pharmacol Exp Ther. 1989 Aug;250(2):476-84. PubMed PMID: 2547933.
4: Gogas KR, Hough LB. Inhibition of naloxone-resistant antinociception by centrally administered H2-antagonists. J Pharmacol Exp Ther. 1989 Jan;248(1):262-7. PubMed PMID: 2563290.
5: Hough LB, Jackowski S, Eberle N, Gogas KR, Camarota NA, Cue D. Actions of the brain-penetrating H2-antagonist zolantidine on histamine dynamics and metabolism in rat brain. Biochem Pharmacol. 1988 Dec 15;37(24):4707-11. PubMed PMID: 3202904.