IUN38767

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526485

CAS#: 190838-76-7

Description: IUN38767, also known as FQ is a novel reversible mixed-type tyrosinase inhibitor. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

img
IUN38767
CAS# 190838-76-7
Instruction

Theoretical Analysis

MedKoo Cat#: 526485
Name: IUN38767
CAS#: 190838-76-7
Chemical Formula: C14H9FN2O
Exact Mass: 240.07
Molecular Weight: 240.240
Elemental Analysis: C, 69.99; H, 3.78; F, 7.91; N, 11.66; O, 6.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: FQ; IUN38767; IUN 38767; IUN-38767;

IUPAC/Chemical Name: 2-(4-Fluorophenyl)-quinazolin-4(3H)-one

InChi Key: IXMXCFSRQIHRHB-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H9FN2O/c15-10-7-5-9(6-8-10)13-16-12-4-2-1-3-11(12)14(18)17-13/h1-8H,(H,16,17,18)

SMILES Code: O=C1NC(C2=CC=C(F)C=C2)=NC3=C1C=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 240.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Luiz GO, Benevides RS, Santos FGS, Espinel YAV, Mayer Alegre TP, Wiederhecker GS. Efficient anchor loss suppression in coupled near-field optomechanical resonators. Opt Express. 2017 Dec 11;25(25):31347-31361. doi: 10.1364/OE.25.031347. PubMed PMID: 29245810.

2: Li Q, Li X, Deng CL. Induction of proliferation and activation of rat hepatic stellate cells via high glucose and high insulin. Eur Rev Med Pharmacol Sci. 2017 Dec;21(23):5420-5429. doi: 10.26355/eurrev_201712_13930. PubMed PMID: 29243785.

3: Arcuri L, Novello S, Frassineti M, Mercatelli D, Pisanò CA, Morella I, Fasano S, Journigan BV, Meyer ME, Polgar WE, Brambilla R, Zaveri NT, Morari M. Antiparkinsonian and antidyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists. Br J Pharmacol. 2017 Dec 12. doi: 10.1111/bph.14123. [Epub ahead of print] PubMed PMID: 29232769.

4: Zaveri NT, Marquez PV, Meyer ME, Polgar WE, Hamid A, Lutfy K. A novel and selective nociceptin receptor (NOP) agonist (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol (AT-312) decreases acquisition of ethanol-induced conditioned place preference in mice. Alcohol Clin Exp Res. 2017 Dec 7. doi: 10.1111/acer.13575. [Epub ahead of print] PubMed PMID: 29215139.

5: Wu J, Lan F, Lu Y, He Q, Li B. Molecular Characteristics of ST1193 Clone among Phylogenetic Group B2 Non-ST131 Fluoroquinolone-Resistant Escherichia coli. Front Microbiol. 2017 Nov 21;8:2294. doi: 10.3389/fmicb.2017.02294. eCollection 2017. PubMed PMID: 29209300; PubMed Central PMCID: PMC5702334.

6: Salinas G, Comini MA. Alternative Thiol-Based Redox Systems. Antioxid Redox Signal. 2017 Dec 5. doi: 10.1089/ars.2017.7464. [Epub ahead of print] PubMed PMID: 29207877.

7: Vidal L, Antúnez L, Giménez A, Medina K, Boido E, Ares G. Sensory characterization of the astringency of commercial Uruguayan Tannat wines. Food Res Int. 2017 Dec;102:425-434. doi: 10.1016/j.foodres.2017.09.022. Epub 2017 Sep 9. PubMed PMID: 29195968.

8: Antúnez L, Giménez A, Ares G. A consumer-based approach to salt reduction: Case study with bread. Food Res Int. 2016 Dec;90:66-72. doi: 10.1016/j.foodres.2016.10.015. Epub 2016 Oct 20. PubMed PMID: 29195892.

9: Rising R, Foerster T, Arad AD, Albu J, Pi-Sunyer X. Validation of whole room indirect calorimeters: refinement of current methodologies. Physiol Rep. 2017 Nov;5(22). pii: e13521. doi: 10.14814/phy2.13521. PubMed PMID: 29180485; PubMed Central PMCID: PMC5704087.

10: Garmendia G, Umpierrez-Failache M, Ward TJ, Vero S. Development of a PCR-RFLP method based on the transcription elongation factor 1-α gene to differentiate Fusarium graminearum from other species within the Fusarium graminearum species complex. Food Microbiol. 2018 Apr;70:28-32. doi: 10.1016/j.fm.2017.08.020. Epub 2017 Aug 28. PubMed PMID: 29173636.

11: Okaikue-Woodi FEK, Kelch SE, Schmidt MP, Enid Martinez C, Youngman RE, Aristilde L. Structures and mechanisms in clay nanopore trapping of structurally-different fluoroquinolone antimicrobials. J Colloid Interface Sci. 2017 Nov 8;513:367-378. doi: 10.1016/j.jcis.2017.11.020. [Epub ahead of print] PubMed PMID: 29169026.

12: Kondratskyi A, Kondratska K, Vanden Abeele F, Gordienko D, Dubois C, Toillon RA, Slomianny C, Lemière S, Delcourt P, Dewailly E, Skryma R, Biot C, Prevarskaya N. Ferroquine, the next generation antimalarial drug, has antitumor activity. Sci Rep. 2017 Nov 21;7(1):15896. doi: 10.1038/s41598-017-16154-2. PubMed PMID: 29162859; PubMed Central PMCID: PMC5698296.

13: Farid S, Mahmood M, Abu Saleh OM, Hamadah A, Nasr SH, Garrigos ZE, Leung N, Sohail MR. Clinical Manifestations and Outcomes of Fluoroquinolone-Related Acute Interstitial Nephritis. Mayo Clin Proc. 2017 Nov 17. pii: S0025-6196(17)30695-X. doi: 10.1016/j.mayocp.2017.08.024. [Epub ahead of print] PubMed PMID: 29157532.

14: Tzschentke TM, Rutten K. Mu-opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptor activation both contribute to the discriminative stimulus properties of cebranopadol in the rat. Neuropharmacology. 2018 Feb;129:100-108. doi: 10.1016/j.neuropharm.2017.11.026. Epub 2017 Nov 16. PubMed PMID: 29155273.

15: Yaghoubi S, Ranjbar R, Soltan Dallal MM, Shirazi MH, Sharifi-Yazdi MK. The Frequency of Mutations in Quinolone Resistance-Determining Regions and Plasmid-Mediated Quinolone Resistance in Shigella Isolates Recovered from Pediatric Patients in Tehran, Iran: An Overlooked Problem. Microb Drug Resist. 2017 Nov 17. doi: 10.1089/mdr.2017.0155. [Epub ahead of print] PubMed PMID: 29148915.

16: Yadav S, Goel N, Kumar V, Tikoo K, Singhal S. Removal of fluoroquinolone from aqueous solution using graphene oxide: experimental and computational elucidation. Environ Sci Pollut Res Int. 2017 Nov 16. doi: 10.1007/s11356-017-0596-8. [Epub ahead of print] PubMed PMID: 29147984.

17: Michalak K, Sobolewska-Włodarczyk A, Włodarczyk M, Sobolewska J, Woźniak P, Sobolewski B. Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications. Oxid Med Cell Longev. 2017;2017:8023935. doi: 10.1155/2017/8023935. Epub 2017 Sep 25. Review. PubMed PMID: 29147464; PubMed Central PMCID: PMC5632915.

18: Jesús F, Hladki R, Gérez N, Besil N, Niell S, Fernández G, Heinzen H, Cesio MV. Miniaturized QuEChERS based methodology for multiresidue determination of pesticides in odonate nymphs as ecosystem biomonitors. Talanta. 2018 Feb 1;178:410-418. doi: 10.1016/j.talanta.2017.09.014. Epub 2017 Sep 8. PubMed PMID: 29136841.

19: Takahara M, Wakabayashi R, Minamihata K, Goto M, Kamiya N. Primary Amine-Clustered DNA Aptamer for DNA-Protein Conjugation Catalyzed by Microbial Transglutaminase. Bioconjug Chem. 2017 Nov 20. doi: 10.1021/acs.bioconjchem.7b00594. [Epub ahead of print] PubMed PMID: 29131594.

20: Ingold M, Dapueto R, Victoria S, Galliusi G, Batthyàny C, Bollati-Fogolín M, Tejedor D, García-Tellado F, Padrón JM, Porcal W, López GV. A green multicomponent synthesis of tocopherol analogues with antiproliferative activities. Eur J Med Chem. 2017 Nov 3. pii: S0223-5234(17)30888-7. doi: 10.1016/j.ejmech.2017.11.003. [Epub ahead of print] PubMed PMID: 29129514.