CaCCinh-A01
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MedKoo CAT#: 555104

CAS#: 407587-33-1

Description: CaCCinh-A01, also known as TMEM16 Blocker I, is a TMEM16 Blocker. CaCCinh-A01 is a non-selective inhibitor of calcium-activated chloride channels (CaCCs) that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC50 = 10 µM).


Price and Availability

Size Price Shipping out time Quantity
10mg USD 90 Same day
25mg USD 150 Same day
50mg USD 250 Same day
100mg USD 450 Same day
200mg USD 750 Same day
500mg USD 1650 Same day
1g USD 2650 2 Weeks
2g USD 4650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-20. Prices are subject to change without notice.

CaCCinh-A01, purity > 98%, is in stock. The same day shipping after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555104
Name: CaCCinh-A01
CAS#: 407587-33-1
Chemical Formula: C18H21NO4S
Exact Mass: 347.1191
Molecular Weight: 347.429
Elemental Analysis: C, 62.23; H, 6.09; N, 4.03; O, 18.42; S, 9.23


Synonym: CaCCinh-A01; CaCC(inh)-A01, TMEM16 Blocker I.

IUPAC/Chemical Name: 6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid

InChi Key: ACLUEOBQFRYTQS-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H21NO4S/c1-18(2,3)10-6-7-11-13(9-10)24-16(14(11)17(21)22)19-15(20)12-5-4-8-23-12/h4-5,8,10H,6-7,9H2,1-3H3,(H,19,20)(H,21,22)

SMILES Code: O=C(C1=C(NC(C2=CC=CO2)=O)SC3=C1CCC(C(C)(C)C)C3)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Hannigan KI, Griffin CS, Large RJ, Sergeant GP, Hollywood MA, McHale NG, Thornbury KD. The role of Ca(2+)-activated Cl(-) current in tone generation in the rabbit corpus cavernosum. Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C475-C486. doi: 10.1152/ajpcell.00025.2017. Epub 2017 Aug 23. PubMed PMID: 28835432.

2: Fedigan S, Bradley E, Webb T, Large RJ, Hollywood MA, Thornbury KD, McHale NG, Sergeant GP. Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal. Pflugers Arch. 2017 Jul 21. doi: 10.1007/s00424-017-2028-5. [Epub ahead of print] PubMed PMID: 28733893.

3: Banerjee J, Leung CT, Li A, Peterson-Yantorno K, Ouyang H, Stamer WD, Civan MM. Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):492-501. doi: 10.1167/iovs.16-20188. PubMed PMID: 28125837; PubMed Central PMCID: PMC5283088.

4: Yu B, Jiang Y, Jin L, Ma T, Yang H. Role of Quercetin in Modulating Chloride Transport in the Intestine. Front Physiol. 2016 Nov 23;7:549. eCollection 2016. PubMed PMID: 27932986; PubMed Central PMCID: PMC5120089.

5: Guan L, Song Y, Gao J, Gao J, Wang K. Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells. Oncotarget. 2016 Nov 29;7(48):78619-78630. doi: 10.18632/oncotarget.12524. PubMed PMID: 27732935; PubMed Central PMCID: PMC5346664.

6: Kamikawa A, Ichii O, Sakazaki J, Ishikawa T. Ca2+-activated Cl- channel currents in mammary secretory cells from lactating mouse. Am J Physiol Cell Physiol. 2016 Nov 1;311(5):C808-C819. doi: 10.1152/ajpcell.00050.2016. Epub 2016 Aug 24. PubMed PMID: 27558156.

7: Gianotti A, Ferrera L, Philp AR, Caci E, Zegarra-Moran O, Galietta LJ, Flores CA. Pharmacological analysis of epithelial chloride secretion mechanisms in adult murine airways. Eur J Pharmacol. 2016 Jun 15;781:100-8. doi: 10.1016/j.ejphar.2016.04.007. Epub 2016 Apr 7. PubMed PMID: 27063443.

8: Hwang SJ, Basma N, Sanders KM, Ward SM. Effects of new-generation inhibitors of the calcium-activated chloride channel anoctamin 1 on slow waves in the gastrointestinal tract. Br J Pharmacol. 2016 Apr;173(8):1339-49. doi: 10.1111/bph.13431. Epub 2016 Mar 6. PubMed PMID: 26774021; PubMed Central PMCID: PMC4940814.

9: Chatterjee T, Sheikh IA, Chakravarty D, Chakrabarti P, Sarkar P, Saha T, Chakrabarti MK, Hoque KM. Effects of Small Molecule Calcium-Activated Chloride Channel Inhibitors on Structure and Function of Accessory Cholera Enterotoxin (Ace) of Vibrio cholerae. PLoS One. 2015 Nov 5;10(11):e0141283. doi: 10.1371/journal.pone.0141283. eCollection 2015. PubMed PMID: 26540279; PubMed Central PMCID: PMC4634967.

10: Cherkashin AP, Kolesnikova AS, Tarasov MV, Romanov RA, Rogachevskaja OA, Bystrova MF, Kolesnikov SS. Expression of calcium-activated chloride channels Ano1 and Ano2 in mouse taste cells. Pflugers Arch. 2016 Feb;468(2):305-19. doi: 10.1007/s00424-015-1751-z. Epub 2015 Nov 3. PubMed PMID: 26530828.

11: Pineda-Farias JB, Barragán-Iglesias P, Loeza-Alcocer E, Torres-López JE, Rocha-González HI, Pérez-Severiano F, Delgado-Lezama R, Granados-Soto V. Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats. Mol Pain. 2015 Jul 1;11:41. doi: 10.1186/s12990-015-0042-1. PubMed PMID: 26130088; PubMed Central PMCID: PMC4487556.

12: Boedtkjer DM, Kim S, Jensen AB, Matchkov VM, Andersson KE. New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br J Pharmacol. 2015 Aug;172(16):4158-72. doi: 10.1111/bph.13201. Epub 2015 Jul 8. PubMed PMID: 26013995; PubMed Central PMCID: PMC4543620.

13: Sanders KM, O'Driscoll K, Leblanc N. Pharmacological properties of native CaCCs and TMEM16A. Channels (Austin). 2014;8(6):473-4. doi: 10.4161/19336950.2014.986624. PubMed PMID: 25528999; PubMed Central PMCID: PMC4594607.

14: Sauter DRP, Novak I, Pedersen SF, Larsen EH, Hoffmann EK. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508. doi: 10.1007/s00424-014-1598-8. Epub 2014 Aug 28. PubMed PMID: 25163766; PubMed Central PMCID: PMC4464647.

15: Liu Y, Zhang H, Huang D, Qi J, Xu J, Gao H, Du X, Gamper N, Zhang H. Characterization of the effects of Cl⁻ channel modulators on TMEM16A and bestrophin-1 Ca²⁺ activated Cl⁻ channels. Pflugers Arch. 2015 Jul;467(7):1417-1430. doi: 10.1007/s00424-014-1572-5. Epub 2014 Aug 1. PubMed PMID: 25078708.

16: García G, Martínez-Rojas VA, Rocha-González HI, Granados-Soto V, Murbartián J. Evidence for the participation of Ca(2+)-activated chloride channels in formalin-induced acute and chronic nociception. Brain Res. 2014 Sep 4;1579:35-44. doi: 10.1016/j.brainres.2014.07.011. Epub 2014 Jul 15. PubMed PMID: 25036442.

17: Bill A, Hall ML, Borawski J, Hodgson C, Jenkins J, Piechon P, Popa O, Rothwell C, Tranter P, Tria S, Wagner T, Whitehead L, Gaither LA. Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics. J Biol Chem. 2014 Apr 18;289(16):11029-41. doi: 10.1074/jbc.M114.549188. Epub 2014 Mar 5. PubMed PMID: 24599954; PubMed Central PMCID: PMC4036244.

18: Qi J, Wang Y, Liu Y, Zhang F, Guan B, Zhang H. Development and validation of HTS assay for screening the calcium-activated chloride channel modulators in TMEM16A stably expressed CHO cells. Anal Bioanal Chem. 2014 Feb;406(6):1713-21. doi: 10.1007/s00216-013-7550-5. Epub 2014 Jan 22. PubMed PMID: 24448969.

19: Ko EA, Jin BJ, Namkung W, Ma T, Thiagarajah JR, Verkman AS. Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice. Gut. 2014 Jul;63(7):1120-9. doi: 10.1136/gutjnl-2013-305663. Epub 2013 Sep 19. PubMed PMID: 24052273; PubMed Central PMCID: PMC4048772.

20: Ousingsawat J, Kongsuphol P, Schreiber R, Kunzelmann K. CFTR and TMEM16A are separate but functionally related Cl- channels. Cell Physiol Biochem. 2011;28(4):715-24. doi: 10.1159/000335765. Epub 2011 Dec 14. PubMed PMID: 22178883.