WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561638
Description: Carbetapentane Citrate is an agonist of the sigma-1 receptor. It also binds the serotonin 5-HT3 and muscarinic acetylcholine receptors. Carbetapentane Citrate is a potent antitussive, anticonvulsant, and spasmolytic agent in clinical trials.
MedKoo Cat#: 561638
Name: Carbetapentane Citrate
Chemical Formula: C26H39NO10
Molecular Weight: 525.59
Elemental Analysis: C, 59.42; H, 7.48; N, 2.66; O, 30.44
Synonym: Pentoxyverine citrate; Pentoxiverine citrate; Loucarbate; Carbetapentane Citrate;
IUPAC/Chemical Name: 2-[2-(Diethylamino)ethoxy]ethyl 1-phenylcyclopentane-1-carboxylate citrate
InChi Key: AKJDEXBCRLOVTH-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H31NO3.C6H8O7/c1-3-21(4-2)14-15-23-16-17-24-19(22)20(12-8-9-13-20)18-10-6-5-7-11-18;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-7,10-11H,3-4,8-9,12-17H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
SMILES Code: O=C(C1(C2=CC=CC=C2)CCCC1)OCCOCCN(CC)CC.OC(C(O)=O)(CC(O)=O)CC(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 525.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Dönmez OA, Aşçi B, Bozdoğan A, Sungur S. Simultaneous determination of potassium guaiacolsulfonate, guaifenesin, diphenhydramine HCl and carbetapentane citrate in syrups by using HPLC-DAD coupled with partial least squares multivariate calibration. Talanta. 2011 Feb 15;83(5):1601-5. doi: 10.1016/j.talanta.2010.11.054. Epub 2010 Nov 30. PubMed PMID: 21238758.
2: Food and Drug Administration, HHS. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use; final rule for over-the-counter antitussive drug products; technical amendment. Final rule, technical amendment. Fed Regist. 2007 Nov 30;72(230):67639-40. PubMed PMID: 18064767.
3: Nordenberg J, Perlmutter I, Lavie G, Beery E, Uziel O, Morgenstern C, Fenig E, Weizman A. Anti-proliferative activity of haloperidol in B16 mouse and human SK-MEL-28 melanoma cell lines. Int J Oncol. 2005 Oct;27(4):1097-103. PubMed PMID: 16142328.
4: Meyer C, Schmieding K, Falkenstein E, Wehling M. Are high-affinity progesterone binding site(s) from porcine liver microsomes members of the sigma receptor family? Eur J Pharmacol. 1998 Apr 24;347(2-3):293-9. PubMed PMID: 9653896.
5: Talbott MW, Barch GK, Gabel LP. A new method for evaluating antitussives in cats using an electrode-cannula. Eur J Pharmacol. 1975 Nov;34(1):59-63. PubMed PMID: 1234769.
6: Sato T, Fujita T. [Effects of intravenous injection of carbetapentane citrate on the cardiovascular system and its clinical experiences]. Masui. 1970 Oct;19(11):1255-61. Japanese. PubMed PMID: 5528949.