Sarafloxacin HCl | CAS#91296-87-6 | antibacterial

Sarafloxacin HCl
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561622

CAS#: 91296-87-6

Description: Sarafloxacin HCl is a broad-spectrum fluoroquinolone antibacterial agent. It inhibits bacterial Topo II α (DNA gyrase, topoisomerase) and is effective against Mycobacterium tuberculosis.

Chemical Structure

Sarafloxacin HCl

CAS# 91296-87-6

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 561622
Name: Sarafloxacin HCl
CAS#: 91296-87-6
Chemical Formula: C20H18ClF2N3O3
Exact Mass: 0.00
Molecular Weight: 421.830
Elemental Analysis: C, 56.95; H, 4.30; Cl, 8.40; F, 9.01; N, 9.96; O, 11.38

Price and Availability

Size	Price	Availability	Quantity
1g	USD 400	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Sarafloxacin HCl; Sarafloxacin Hydrochloride; A-56620; A 56620; A56620;

IUPAC/Chemical Name: 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride

InChi Key: KNWODGJQLCISLC-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H17F2N3O3.ClH/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24;/h1-4,9-11,23H,5-8H2,(H,27,28);1H

SMILES Code: O=C(C1=CN(C2=CC=C(F)C=C2)C3=C(C=C(F)C(N4CCNCC4)=C3)C1=O)O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

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Product Data:

Product Data

Instruction:

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Biological target:	Sarafloxacin HCl is a hydrochloride salt form of sarafloxacin, a quinolone antibiotic drug with IC50 of 0.96 μg/L.
In vitro activity:	Sarafloxacin, serving as a model for fluoroquinolones, was examined for its absorption kinetics in Caco-2 cells. The study aimed to understand the mechanisms behind its intestinal transport. In Caco-2 cells, sarafloxacin demonstrated concentration-dependent permeability in both directions, suggesting the involvement of absorption and efflux carriers. These findings shed light on the complexities of sarafloxacin's absorption and transport mechanisms. Reference: J Drug Target. 2005 Apr;13(3):199-212. https://pubmed.ncbi.nlm.nih.gov/16036308/
In vivo activity:	In a study involving Muscovy ducks and avian pathogenic Escherichia coli O78, sarafloxacin was investigated to optimize therapeutic dosages. After intravenous and oral administration, the calculated area under the concentration-time curves were similar, and elimination half-lives varied. A higher dose of sarafloxacin may be needed for effective treatment of E. coli O78 infections, particularly to minimize antimicrobial resistance. Reference: BMC Vet Res. 2017 Feb 10;13(1):47. https://pubmed.ncbi.nlm.nih.gov/28183350/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	4.0	9.48

Preparing Stock Solutions

The following data is based on the product molecular weight 421.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Fernandez-Teruel C, Gonzalez-Alvarez I, Casabó VG, Ruiz-Garcia A, Bermejo M. Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells. J Drug Target. 2005 Apr;13(3):199-212. doi: 10.1080/10611860500087835. PMID: 16036308. 2. McConville ML, Dijkstra JW, Stamm JM, van Saene JJ, Nouws JF. Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q. 1995 Mar;17(1):1-5. doi: 10.1080/01652176.1995.9694519. PMID: 7610549. 3. Yu Y, Zhou YF, Sun J, Shi W, Liao XP, Liu YH. Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks. BMC Vet Res. 2017 Feb 10;13(1):47. doi: 10.1186/s12917-017-0964-0. PMID: 28183350; PMCID: PMC5301423. 4. Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment of Edwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251.
In vitro protocol:	1. Fernandez-Teruel C, Gonzalez-Alvarez I, Casabó VG, Ruiz-Garcia A, Bermejo M. Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells. J Drug Target. 2005 Apr;13(3):199-212. doi: 10.1080/10611860500087835. PMID: 16036308. 2. McConville ML, Dijkstra JW, Stamm JM, van Saene JJ, Nouws JF. Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q. 1995 Mar;17(1):1-5. doi: 10.1080/01652176.1995.9694519. PMID: 7610549.
In vivo protocol:	1. Yu Y, Zhou YF, Sun J, Shi W, Liao XP, Liu YH. Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks. BMC Vet Res. 2017 Feb 10;13(1):47. doi: 10.1186/s12917-017-0964-0. PMID: 28183350; PMCID: PMC5301423. 2. Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment of Edwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251.

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1: Evaluation of certain veterinary drug residues in food. Fiftieth report of the joint FAO/WHO Expert Committee on Food Additives. World Health Organ Tech Rep Ser. 1999;888:i-vii, 1-95. Review. PubMed PMID: 10416362.

2: Gingerich WH, Stehly GR, Clark KJ, Hayton WL. Crop grouping: a proposal for public aquaculture. Vet Hum Toxicol. 1998;40 Suppl 2:24-31. Review. PubMed PMID: 9823579.

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