Tazanolast

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561608

CAS#: 82989-25-1

Description: Tazanolast is a selective mast-cell-stabilizing agent, and inhibits ozone-induced airway hyperresponsiveness.


Chemical Structure

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Tazanolast
CAS# 82989-25-1

Theoretical Analysis

MedKoo Cat#: 561608
Name: Tazanolast
CAS#: 82989-25-1
Chemical Formula: C13H15N5O3
Exact Mass: 289.12
Molecular Weight: 289.290
Elemental Analysis: C, 53.97; H, 5.23; N, 24.21; O, 16.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Tazanolast; WP-833; WP 833; WP833;

IUPAC/Chemical Name: Butyl 2-oxo-2-[3-(2H-tetrazol-5-yl)anilino]acetate

InChi Key: XQTARQNQIVVBRX-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H15N5O3/c1-2-3-7-21-13(20)12(19)14-10-6-4-5-9(8-10)11-15-17-18-16-11/h4-6,8H,2-3,7H2,1H3,(H,14,19)(H,15,16,17,18)

SMILES Code: O=C(OCCCC)C(NC1=CC=CC(C2=NNN=N2)=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 289.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Igarashi A, Iijima H, Tamura G, Shirato K. Tazanolast inhibits ozone-induced airway hyperresponsiveness in guinea pigs. Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1531-5. PubMed PMID: 9603134.

2: Kamei C, Mio M, Yoshida T, Saito Y, Toyoda Y, Tsuriya Y. Effect of an active metabolite of the antiallergic agent tazanolast on histamine release from rat mast cells. Arzneimittelforschung. 1997 Apr;47(4):390-4. PubMed PMID: 9150859.

3: Tominaga T, Watanbe A, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. Effect of TYB-2285 on antigen-induced accumulation of eosinophils into the peritoneal cavity of rats sensitized with Ascaris suum extract. Gen Pharmacol. 1997 Mar;28(3):411-4. PubMed PMID: 9068982.

4: Nishizawa Y, Yamamoto T, Terada N, Fushiki S, Amakata Y, Nishizawa Y. Effects of antiallergic drugs on the proliferation of estrogen-sensitive mouse Leydig cell line. Anticancer Res. 1996 May-Jun;16(3A):1241-5. PubMed PMID: 8702244.

5: Hashimoto T, Toyoda Y, Matsukawa H, Tsuriya Y, Yanagihara Y. [Effect of tazanolast on platelet activating factor-induced airway hyperresponsiveness in guinea pigs]. Arerugi. 1992 Sep;41(9):1430-3. Japanese. PubMed PMID: 1280089.

6: Hashimoto T, Edanami K, Naito A, Sano K, Fushimi H, Goto M. [Anti-allergic effects of tazanolast [butyl 3'-(1H-tetrazol-5-yl) oxanilate, WP-833] metabolites]. Nihon Yakurigaku Zasshi. 1990 Apr;95(4):159-66. Japanese. PubMed PMID: 1695192.