WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584116

CAS#: 77-46-3

Description: Acedapsone, also known as Acetamin, Atilon, Camilan, and Rodilone, is slowly metabolized to give long-term, low blood levels of DAPSONE. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent

Chemical Structure

CAS# 77-46-3

Theoretical Analysis

MedKoo Cat#: 584116
Name: Acedapsone
CAS#: 77-46-3
Chemical Formula: C16H16N2O4S
Exact Mass: 332.0831
Molecular Weight: 332.37
Elemental Analysis: C, 57.82; H, 4.85; N, 8.43; O, 19.25; S, 9.65

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Acedapsone; Acetamin; Atilon; Camilan; Rodilon; BA 2650; BA-2650; BA2650

IUPAC/Chemical Name: N,N'-Diacetyl-4,4'-diaminodiphenylsulfone


InChi Code: InChI=1S/C16H16N2O4S/c1-11(19)17-13-3-7-15(8-4-13)23(21,22)16-9-5-14(6-10-16)18-12(2)20/h3-10H,1-2H3,(H,17,19)(H,18,20)

SMILES Code: O=S(C1=CC=C(NC(C)=O)C=C1)(C2=CC=C(NC(C)=O)C=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 332.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Olivares Sabournin R, González Segredo AB. [Bacteriologic study in patients with multibacillary leprosy treated with rifampicin and acedapsone]. Rev Cubana Med Trop. 1989 May-Aug;41(2):307-12. Spanish. PubMed PMID: 2486227.

2: George J, Balakrishnan S. Blood dapsone levels in leprosy patients treated with acedapsone. Indian J Lepr. 1986 Jul-Sep;58(3):401-6. PubMed PMID: 3794408.

3: Neelan PN, Sirumban P, Sivaprasad N. Limited duration acedapsone prophylaxis in leprosy. Indian J Lepr. 1986 Apr-Jun;58(2):251-6. PubMed PMID: 3543161.

4: Russell DA, Worth RM, Jano B, Fasal P, Shepard CC. Acedapsone in the prevention of leprosy: field trial in three high prevalence villages in Micronesia. Am J Trop Med Hyg. 1979 May;28(3):559-63. PubMed PMID: 453449.

5: Peters JH, Murray JF Jr, Gordon GR, Levy L, Russell DA, Scott GC, Vincin DR, Shepard CC. Acedapsone treatment of leprosy patients: response versus drug disposition. Am J Trop Med Hyg. 1977 Jan;26(1):127-36. PubMed PMID: 842774.

6: Levy L, Peters JH. Susceptibility of Mycobacterium leprae to dapsone as a determinant of patient response to acedapsone. Antimicrob Agents Chemother. 1976 Jan;9(1):102-12. PubMed PMID: 769667; PubMed Central PMCID: PMC429483.

7: Russell DA, Shepard CC, McRae DH, Scott GC, Vincin DR. Acedapsone (DADDS) treatment of leprosy patients in the Karimui of Papua New Guinea: status at six years. Am J Trop Med Hyg. 1975 May;24(3):485-95. PubMed PMID: 1098496.