WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530996
CAS#: 1704801-24-0 (HCl)
Description: AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.
MedKoo Cat#: 530996
Name: AX-024 HCl
CAS#: 1704801-24-0 (HCl)
Chemical Formula: C21H23ClFNO2
Exact Mass: 375.1401
Molecular Weight: 375.8684
Elemental Analysis: C, 67.11; H, 6.17; Cl, 9.43; F, 5.05; N, 3.73; O, 8.51
Related CAS #: 1370544-73-2 (free base) 1704801-24-0 (HCl)
Synonym: AX-024; AX 024; AX024 HCl; AX-024 hydrochloride
IUPAC/Chemical Name: 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride
InChi Key: DGBCIMPGYRVTPD-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H
SMILES Code: COC1=CC(C(C2=CC=C(F)C=C2)=C(CN3CCCC3)CO4)=C4C=C1.[H]Cl
1: Borroto A, Reyes-Garau D, Jiménez MA, Carrasco E, Moreno B, Martínez-Pasamar
S, Cortés JR, Perona A, Abia D, Blanco S, Fuentes M, Arellano I, Lobo J,
Heidarieh H, Rueda J, Esteve P, Cibrián D, Martinez-Riaño A, Mendoza P, Prieto C,
Calleja E, Oeste CL, Orfao A, Fresno M, Sánchez-Madrid F, Alcamí A, Bovolenta P,
Martín P, Villoslada P, Morreale A, Messeguer A, Alarcon B. First-in-class
inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci
Transl Med. 2016 Dec 21;8(370):370ra184. doi: 10.1126/scitranslmed.aaf2140.
PubMed PMID: 28003549.