AX-024 HCl
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MedKoo CAT#: 530996

CAS#: 1704801-24-0 (HCl)

Description: AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.

Chemical Structure

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AX-024 HCl
CAS# 1704801-24-0 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 530996
Name: AX-024 HCl
CAS#: 1704801-24-0 (HCl)
Chemical Formula: C21H23ClFNO2
Exact Mass: 375.14
Molecular Weight: 375.868
Elemental Analysis: C, 67.11; H, 6.17; Cl, 9.43; F, 5.05; N, 3.73; O, 8.51

Price and Availability

Size Price Availability Quantity
10mg USD 90 Ready to ship
25mg USD 190 Ready to ship
50mg USD 350 Ready to ship
100mg USD 650 Ready to ship
200mg USD 950 Ready to ship
500mg USD 1650 Ready to ship
1g USD 2950 Ready to ship
2g USD 4650 Ready to ship
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Related CAS #: 1370544-73-2 (free base)   1704801-24-0 (HCl)    

Synonym: AX-024; AX 024; AX024 HCl; AX-024 hydrochloride

IUPAC/Chemical Name: 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride

InChi Key: DGBCIMPGYRVTPD-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H

SMILES Code: COC1=CC(C(C2=CC=C(F)C=C2)=C(CN3CCCC3)CO4)=C4C=C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.0 143.67
Water 10.3 27.51
Ethanol 18.0 47.89

Preparing Stock Solutions

The following data is based on the product molecular weight 375.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Borroto A, Reyes-Garau D, Jiménez MA, Carrasco E, Moreno B, Martínez-Pasamar
S, Cortés JR, Perona A, Abia D, Blanco S, Fuentes M, Arellano I, Lobo J,
Heidarieh H, Rueda J, Esteve P, Cibrián D, Martinez-Riaño A, Mendoza P, Prieto C,
Calleja E, Oeste CL, Orfao A, Fresno M, Sánchez-Madrid F, Alcamí A, Bovolenta P,
Martín P, Villoslada P, Morreale A, Messeguer A, Alarcon B. First-in-class
inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci
Transl Med. 2016 Dec 21;8(370):370ra184. doi: 10.1126/scitranslmed.aaf2140.
PubMed PMID: 28003549.