AX-024 HCl
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MedKoo CAT#: 530996

CAS#: 1704801-24-0 (HCl)

Description: AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 190 Same Day
50mg USD 350 Same Day
100mg USD 650 Same Day
200mg USD 950 Same Day
500mg USD 1650 Same Day
1g USD 2850 Same Day
2g USD 4250 Same Day
5g USD 6950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-20. Prices are subject to change without notice.

AX-024 HCl, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530996
Name: AX-024 HCl
CAS#: 1704801-24-0 (HCl)
Chemical Formula: C21H23ClFNO2
Exact Mass: 375.1401
Molecular Weight: 375.8684
Elemental Analysis: C, 67.11; H, 6.17; Cl, 9.43; F, 5.05; N, 3.73; O, 8.51


Related CAS #: 1370544-73-2 (free base)   1704801-24-0 (HCl)    

Synonym: AX-024; AX 024; AX024 HCl; AX-024 hydrochloride

IUPAC/Chemical Name: 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride

InChi Key: DGBCIMPGYRVTPD-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H

SMILES Code: COC1=CC(C(C2=CC=C(F)C=C2)=C(CN3CCCC3)CO4)=C4C=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Borroto A, Reyes-Garau D, Jiménez MA, Carrasco E, Moreno B, Martínez-Pasamar
S, Cortés JR, Perona A, Abia D, Blanco S, Fuentes M, Arellano I, Lobo J,
Heidarieh H, Rueda J, Esteve P, Cibrián D, Martinez-Riaño A, Mendoza P, Prieto C,
Calleja E, Oeste CL, Orfao A, Fresno M, Sánchez-Madrid F, Alcamí A, Bovolenta P,
Martín P, Villoslada P, Morreale A, Messeguer A, Alarcon B. First-in-class
inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci
Transl Med. 2016 Dec 21;8(370):370ra184. doi: 10.1126/scitranslmed.aaf2140.
PubMed PMID: 28003549.