WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530994
CAS#: 1154097-71-8
Description: OX4 is a potent inhibitor of PHD2 (IC50 = 1.6 nM). IOX4 induces HIFα in cells and in wildtype mice with marked induction in the brain tissue, revealing that it is useful for studies aimed at validating the upregulation of HIF for treatment of cerebral diseases including stroke.
MedKoo Cat#: 530994
Name: IOX4
CAS#: 1154097-71-8
Chemical Formula: C15H16N6O3
Exact Mass: 328.1284
Molecular Weight: 328.332
Elemental Analysis: C, 54.87; H, 4.91; N, 25.60; O, 14.62
Synonym: IOX4; IOX-4; IOX 4.
IUPAC/Chemical Name: tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate
InChi Key: HWQQDVNGHZIALS-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H16N6O3/c1-15(2,3)24-14(23)10-4-5-12(16-8-10)21-13(22)11(9-18-21)20-7-6-17-19-20/h4-9,18H,1-3H3
SMILES Code: CC(C)(C)OC(C1=CN=C(N2NC=C(N3C=CN=N3)C2=O)C=C1)=O
1: Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V,
Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura
A, Pugh CW, Ratcliffe PJ, Schofield CJ. Potent and Selective Triazole-Based
Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in
the Murine Brain. PLoS One. 2015 Jul 6;10(7):e0132004. doi:
10.1371/journal.pone.0132004. eCollection 2015. PubMed PMID: 26147748; PubMed
Central PMCID: PMC4492579.