IOX4
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530994

CAS#: 1154097-71-8

Description: OX4 is a potent inhibitor of PHD2 (IC50 = 1.6 nM). IOX4 induces HIFα in cells and in wildtype mice with marked induction in the brain tissue, revealing that it is useful for studies aimed at validating the upregulation of HIF for treatment of cerebral diseases including stroke.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 190 2 Weeks
100mg USD 650 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2750 2 Weeks
5g USD 6950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-26. Prices are subject to change without notice.

IOX4, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530994
Name: IOX4
CAS#: 1154097-71-8
Chemical Formula: C15H16N6O3
Exact Mass: 328.1284
Molecular Weight: 328.332
Elemental Analysis: C, 54.87; H, 4.91; N, 25.60; O, 14.62


Synonym: IOX4; IOX-4; IOX 4.

IUPAC/Chemical Name: tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate

InChi Key: HWQQDVNGHZIALS-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H16N6O3/c1-15(2,3)24-14(23)10-4-5-12(16-8-10)21-13(22)11(9-18-21)20-7-6-17-19-20/h4-9,18H,1-3H3

SMILES Code: CC(C)(C)OC(C1=CN=C(N2NC=C(N3C=CN=N3)C2=O)C=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V,
Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura
A, Pugh CW, Ratcliffe PJ, Schofield CJ. Potent and Selective Triazole-Based
Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in
the Murine Brain. PLoS One. 2015 Jul 6;10(7):e0132004. doi:
10.1371/journal.pone.0132004. eCollection 2015. PubMed PMID: 26147748; PubMed
Central PMCID: PMC4492579.