WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530993
CAS#: 120241-79-4
Description: 3-TYP is an inhibitor of SIRT3.
MedKoo Cat#: 530993
Name: 3-TYP
CAS#: 120241-79-4
Chemical Formula: C7H6N4
Exact Mass: 146.0592
Molecular Weight: 146.15
Elemental Analysis: C, 57.53; H, 4.14; N, 38.34
Synonym: 3-TYP; 3TYP; 3 TYP
IUPAC/Chemical Name: 3-(1H-1,2,3-triazol-4-yl) pyridine
InChi Key: VYXFEFOIYPNBFK-UHFFFAOYSA-N
InChi Code: InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)
SMILES Code: C1(C2=CNN=N2)=CC=CN=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 146.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Zhai M, Li B, Duan W, Jing L, Zhang B, Zhang M, Yu L, Liu Z, Yu B, Ren K, Gao
E, Yang Y, Liang H, Jin Z, Yu S. Melatonin ameliorates myocardial ischemia
reperfusion injury through SIRT3-dependent regulation of oxidative stress and
apoptosis. J Pineal Res. 2017 Sep;63(2). doi: 10.1111/jpi.12419. Epub 2017 Jun
20. PubMed PMID: 28500761.
2: Zeng Z, Yang Y, Dai X, Xu S, Li T, Zhang Q, Zhao KS, Chen Z. Polydatin
ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3
activation-mediated mitochondrial protection. Expert Opin Ther Targets. 2016
Jun;20(6):645-52. doi: 10.1080/14728222.2016.1177023. Epub 2016 Apr 22. PubMed
PMID: 27067422.
3: Pi H, Xu S, Reiter RJ, Guo P, Zhang L, Li Y, Li M, Cao Z, Tian L, Xie J, Zhang
R, He M, Lu Y, Liu C, Duan W, Yu Z, Zhou Z. SIRT3-SOD2-mROS-dependent autophagy
in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy.
2015;11(7):1037-51. doi: 10.1080/15548627.2015.1052208. PubMed PMID: 26120888;
PubMed Central PMCID: PMC4590599.
Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide-dependent histone deacetylases. Sirtuin-3 (SIRT3) is a member of the sirtuin family that is localized primarily to the mitochondria and protects against oxidative stress-related diseases, including myocardial ischemia/reperfusion (MI/R) injury. Melatonin has a favorable effect in ameliorating MI/R injury. We hypothesized that melatonin protects against MI/R injury by activating the SIRT3 signaling pathway.
