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MedKoo CAT#: 530993
CAS#: 120241-79-4
Description: 3-TYP is an inhibitor of SIRT3.
MedKoo Cat#: 530993
Name: 3-TYP
CAS#: 120241-79-4
Chemical Formula: C7H6N4
Exact Mass: 146.0592
Molecular Weight: 146.15
Elemental Analysis: C, 57.53; H, 4.14; N, 38.34
Synonym: 3-TYP; 3TYP; 3 TYP
IUPAC/Chemical Name: 3-(1H-1,2,3-triazol-4-yl) pyridine
InChi Key: VYXFEFOIYPNBFK-UHFFFAOYSA-N
InChi Code: InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)
SMILES Code: C1(C2=CNN=N2)=CC=CN=C1
Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide-dependent histone deacetylases. Sirtuin-3 (SIRT3) is a member of the sirtuin family that is localized primarily to the mitochondria and protects against oxidative stress-related diseases, including myocardial ischemia/reperfusion (MI/R) injury. Melatonin has a favorable effect in ameliorating MI/R injury. We hypothesized that melatonin protects against MI/R injury by activating the SIRT3 signaling pathway.
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E, Yang Y, Liang H, Jin Z, Yu S. Melatonin ameliorates myocardial ischemia
reperfusion injury through SIRT3-dependent regulation of oxidative stress and
apoptosis. J Pineal Res. 2017 Sep;63(2). doi: 10.1111/jpi.12419. Epub 2017 Jun
20. PubMed PMID: 28500761.
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ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3
activation-mediated mitochondrial protection. Expert Opin Ther Targets. 2016
Jun;20(6):645-52. doi: 10.1080/14728222.2016.1177023. Epub 2016 Apr 22. PubMed
PMID: 27067422.
3: Pi H, Xu S, Reiter RJ, Guo P, Zhang L, Li Y, Li M, Cao Z, Tian L, Xie J, Zhang
R, He M, Lu Y, Liu C, Duan W, Yu Z, Zhou Z. SIRT3-SOD2-mROS-dependent autophagy
in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy.
2015;11(7):1037-51. doi: 10.1080/15548627.2015.1052208. PubMed PMID: 26120888;
PubMed Central PMCID: PMC4590599.