3-TYP
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MedKoo CAT#: 530993

CAS#: 120241-79-4

Description: 3-TYP is an inhibitor of SIRT3.


Chemical Structure

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3-TYP
CAS# 120241-79-4

Theoretical Analysis

MedKoo Cat#: 530993
Name: 3-TYP
CAS#: 120241-79-4
Chemical Formula: C7H6N4
Exact Mass: 146.0592
Molecular Weight: 146.15
Elemental Analysis: C, 57.53; H, 4.14; N, 38.34

Price and Availability

Size Price Availability Quantity
25.0mg USD 90.0 Same day
50.0mg USD 150.0 same day
100.0mg USD 250.0 Same day
200.0mg USD 450.0 Same day
500.0mg USD 950.0 Same day
1.0g USD 1650.0 Same day
2.0g USD 2950.0 Same day
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Synonym: 3-TYP; 3TYP; 3 TYP

IUPAC/Chemical Name: 3-(1H-1,2,3-triazol-4-yl) pyridine

InChi Key: VYXFEFOIYPNBFK-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)

SMILES Code: C1(C2=CNN=N2)=CC=CN=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 146.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhai M, Li B, Duan W, Jing L, Zhang B, Zhang M, Yu L, Liu Z, Yu B, Ren K, Gao
E, Yang Y, Liang H, Jin Z, Yu S. Melatonin ameliorates myocardial ischemia
reperfusion injury through SIRT3-dependent regulation of oxidative stress and
apoptosis. J Pineal Res. 2017 Sep;63(2). doi: 10.1111/jpi.12419. Epub 2017 Jun
20. PubMed PMID: 28500761.

2: Zeng Z, Yang Y, Dai X, Xu S, Li T, Zhang Q, Zhao KS, Chen Z. Polydatin
ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3
activation-mediated mitochondrial protection. Expert Opin Ther Targets. 2016
Jun;20(6):645-52. doi: 10.1080/14728222.2016.1177023. Epub 2016 Apr 22. PubMed
PMID: 27067422.

3: Pi H, Xu S, Reiter RJ, Guo P, Zhang L, Li Y, Li M, Cao Z, Tian L, Xie J, Zhang
R, He M, Lu Y, Liu C, Duan W, Yu Z, Zhou Z. SIRT3-SOD2-mROS-dependent autophagy
in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy.
2015;11(7):1037-51. doi: 10.1080/15548627.2015.1052208. PubMed PMID: 26120888;
PubMed Central PMCID: PMC4590599.

3-TYP

25.0mg / USD 90.0


Additional Information

Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide-dependent histone deacetylases. Sirtuin-3 (SIRT3) is a member of the sirtuin family that is localized primarily to the mitochondria and protects against oxidative stress-related diseases, including myocardial ischemia/reperfusion (MI/R) injury. Melatonin has a favorable effect in ameliorating MI/R injury. We hypothesized that melatonin protects against MI/R injury by activating the SIRT3 signaling pathway.