Flurbiprofen Axetil
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561579

CAS#: 91503-79-6

Description: Flurbiprofen Axetil, also known as Ropion, is a prodrug of Flurbiprofen that provides better analgesia effects and few side effects.

Chemical Structure

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Flurbiprofen Axetil
CAS# 91503-79-6
Instruction

Theoretical Analysis

MedKoo Cat#: 561579
Name: Flurbiprofen Axetil
CAS#: 91503-79-6
Chemical Formula: C19H19FO4
Exact Mass: 330.13
Molecular Weight: 330.350
Elemental Analysis: C, 69.08; H, 5.80; F, 5.75; O, 19.37

Price and Availability

Size Price Availability Quantity
250mg USD 300 2 Weeks
1g USD 750 2 Weeks
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Synonym: Flurbiprofen Axetil; Ropion; Ropiopn; Lipfen; LFP-83;

IUPAC/Chemical Name: 1-Acetyloxyethyl 2-(3-fluoro-4-phenylphenyl)propanoate

InChi Key: ALIVXCSEERJYHU-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H19FO4/c1-12(19(22)24-14(3)23-13(2)21)16-9-10-17(18(20)11-16)15-7-5-4-6-8-15/h4-12,14H,1-3H3

SMILES Code: CC(C1=CC=C(C2=CC=CC=C2)C(F)=C1)C(OC(OC(C)=O)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 330.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Luo X, Lv F, Peng M. Analgesic effect of different dosage of Flurbiprofen axetil in laparoscopic cholecystectomy in comparison with other analgesic drugs. Pak J Pharm Sci. 2017 Sep;30(5(Special)):1895-1898. PubMed PMID: 29084663.

2: Huang S, Cao X, Li J, Han Y. Analgesic effect of flurbiprofen axetil in treatment of single hole thoracoscopic surgery for pneumothorax. Pak J Pharm Sci. 2017 Sep;30(5(Special)):1875-1882. PubMed PMID: 29084660.

3: Ma XD, Li BP, Wang DL, Yang WS. Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery. Exp Ther Med. 2017 Sep;14(3):2148-2152. doi: 10.3892/etm.2017.4717. Epub 2017 Jul 4. PubMed PMID: 28962135; PubMed Central PMCID: PMC5609191.

4: Zhang H, Gu J, Feng Y, An H. Absorption kinetics of flurbiprofen axetil microspheres in cerebrospinal fluid: A pilot study. Int J Clin Pharmacol Ther. 2017 Nov;55(11):875-880. doi: 10.5414/CP203092. PubMed PMID: 28956529.

5: Wang K, Luo J, Zheng L, Luo T. Preoperative flurbiprofen axetil administration for acute postoperative pain: a meta-analysis of randomized controlled trials. J Anesth. 2017 Dec;31(6):852-860. doi: 10.1007/s00540-017-2409-0. Epub 2017 Sep 21. PubMed PMID: 28936554.

6: Jiang XY, Shu LW, Pan CX. [Efficacy of patient-controlled intravenous analgesia with hydromorphone hydrochloride plus flurbiprofen axetil after endoscopic sinus surgery]. Zhonghua Yi Xue Za Zhi. 2017 Aug 22;97(32):2516-2519. doi: 10.3760/cma.j.issn.0376-2491.2017.32.009. Chinese. PubMed PMID: 28835059.

7: Lan K, Yang WB, Zhang XW, Bai WJ, Li Q, Xu T. [Application of flurbiprofen axetil in pain management associated during transrectal ultrasound-guided prostate biopsy]. Beijing Da Xue Xue Bao Yi Xue Ban. 2017 Aug 18;49(4):643-647. Chinese. PubMed PMID: 28816281.

8: Takahashi H, Shida D, Tagawa K, Iwamoto R, Arita M, Arai H, Suzuki T. Therapeutic effects of flurbiprofen axetil on mesenteric traction syndrome: randomized clinical trial. BMC Surg. 2017 Aug 11;17(1):90. doi: 10.1186/s12893-017-0286-y. PubMed PMID: 28800765; PubMed Central PMCID: PMC5553989.

9: Zhao H, Feng Y, Jiang Y, Lu Q. Flurbiprofen Axetil Provides Effective Analgesia Without Changing the Pregnancy Rate in Ultrasound-Guided Transvaginal Oocyte Retrieval: A Double-Blind Randomized Controlled Trial. Anesth Analg. 2017 Oct;125(4):1269-1274. doi: 10.1213/ANE.0000000000002025. PubMed PMID: 28430684.

10: Wang R, Yang H, Xue K, Zhao Y, Guo X. Facile Synthesis and Chiral Separation of Chiral Mesoporous Silica Microspheres. J Chromatogr Sci. 2017 Aug 1;55(7):736-741. doi: 10.1093/chromsci/bmx028. PubMed PMID: 28387788.

11: Zhang L, Shu R, Zhao Q, Li Y, Yu Y, Wang G. Preoperative butorphanol and flurbiprofen axetil therapy attenuates remifentanil-induced hyperalgesia after laparoscopic gynaecological surgery: a randomized double-blind controlled trial. Br J Anaesth. 2016 Oct;117(4):504-511. doi: 10.1093/bja/aew248. Epub 2016 Oct 17. PubMed PMID: 28077539.

12: Fujita Y, Hasegawa S, Kato Y, Ishii K, Iwasaki A, Sato T, Sekino Y, Hosono K, Nakajima A, Kubota K. Intravenous injection of low-dose flurbiprofen axetil for preventing post-ERCP pancreatitis in high-risk patients: An interim analysis of the trial. Endosc Int Open. 2016 Oct;4(10):E1078-E1082. Epub 2016 Sep 21. PubMed PMID: 27747282; PubMed Central PMCID: PMC5063645.

13: Yu Z, Wu W, Wu X, Lei H, Gong C, Xu S. Protective effects of dexmedetomidine combined with flurbiprofen axetil on remifentanil-induced hyperalgesia: A randomized controlled trial. Exp Ther Med. 2016 Oct;12(4):2622-2628. Epub 2016 Sep 8. PubMed PMID: 27698764; PubMed Central PMCID: PMC5038600.

14: Zhang L, Shu R, Zhao Q, Li Y, Wang C, Wang H, Yu Y, Wang G. Preoperative But Not Postoperative Flurbiprofen Axetil Alleviates Remifentanil-induced Hyperalgesia After Laparoscopic Gynecological Surgery: A Prospective, Randomized, Double-blinded, Trial. Clin J Pain. 2017 May;33(5):435-442. doi: 10.1097/AJP.0000000000000416. PubMed PMID: 27518488.

15: Takahashi H, Shida D, Tagawa K, Suzuki T. Hemodynamics of mesenteric traction syndrome measured by FloTrac sensor. J Clin Anesth. 2016 May;30:46-50. doi: 10.1016/j.jclinane.2015.12.001. Epub 2016 Feb 21. PubMed PMID: 27041263.

16: Wang J, Li H, Ma H, Wang N. Effect of Preemptive Flurbiprofen Axetil and Tramadol on Transurethral Resection of the Prostate under Spinal Anesthesia. Pain Res Treat. 2016;2016:3942040. doi: 10.1155/2016/3942040. Epub 2016 Feb 9. PubMed PMID: 26977315; PubMed Central PMCID: PMC4762999.

17: Chen TY, Zhou J, Wang K, Xu JJ, Ma W, Wu YY. [Electroacupuncture Intervention Combined with Anesthetics for Analgesia and Post-surgical Gastrointestinal Recovery in Pneumectomy Patients]. Zhen Ci Yan Jiu. 2015 Dec;40(6):461-4. Chinese. PubMed PMID: 26887207.

18: Nonaka T, Hara M, Miyamoto C, Sugita M, Yamamoto T. Comparison of the analgesic effect of intravenous acetaminophen with that of flurbiprofen axetil on post-breast surgery pain: a randomized controlled trial. J Anesth. 2016 Jun;30(3):405-9. doi: 10.1007/s00540-016-2150-0. Epub 2016 Feb 16. PubMed PMID: 26882922.

19: Lu Y, Li Y, Li F, Jiang C. [Perspective randomized control study on different NSAIDs drugs after rotator cuff repair]. Zhonghua Yi Xue Za Zhi. 2015 Aug 4;95(29):2337-41. Chinese. PubMed PMID: 26711065.

20: Jiang WW, Wang QH, Peng P, Liao YJ, Duan HX, Xu M, Li Y, Zhang PB. Effects of flurbiprofen axetil on postoperative serum IL-2 and IL-6 levels in patients with colorectal cancer. Genet Mol Res. 2015 Dec 9;14(4):16469-75. doi: 10.4238/2015.December.9.18. PubMed PMID: 26662445.