WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561543
CAS#: 78111-17-8
Description: Okadaic Acid is a toxin produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. Okadaic Acid and its relatives are protein phosphatase inhibitors, specifically targeting protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A).
MedKoo Cat#: 561543
Name: Okadaic Acid
CAS#: 78111-17-8
Chemical Formula: C44H68O13
Exact Mass: 804.466
Molecular Weight: 805.01
Elemental Analysis: C, 65.65; H, 8.51; O, 25.84
This product is not in stock, which may be available by custom synthesis.
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Synonym: Okadaic Acid;
IUPAC/Chemical Name: (R)-2-hydroxy-3-((2S,5R,6R,8S)-5-hydroxy-8-((R,E)-4-((2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-((1S,3S)-1-hydroxy-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl)-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl)but-3-en-2-yl)-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)-2-methylpropanoic acid
InChi Key: QNDVLZJODHBUFM-WFXQOWMNSA-N
InChi Code: InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1
SMILES Code: OC([C@](C)(O)C[C@]1([H])CC[C@@H](O)[C@@]2(O[C@@]([C@H](C)/C=C/[C@]3([H])O[C@]4(CC[C@](O[C@@]([C@@H](O)C[C@H](C)[C@@]5([H])O[C@@]6(CCCCO6)CC[C@H]5C)([H])C([C@H]7O)=C)([H])[C@@]7([H])O4)CC3)([H])CC(C)=C2)O1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 805.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Fujiki H, Sueoka E, Rawangkan A, Suganuma M. Human cancer stem cells are a target for cancer prevention using (-)-epigallocatechin gallate. J Cancer Res Clin Oncol. 2017 Sep 23. doi: 10.1007/s00432-017-2515-2. [Epub ahead of print] Review. PubMed PMID: 28942499.
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7: Zimmer ER, Leuzy A, Souza DO, Portela LV. Inhibition of Protein Phosphatase 2A: Focus on the Glutamatergic System. Mol Neurobiol. 2016 Aug;53(6):3753-3755. doi: 10.1007/s12035-015-9321-0. Epub 2015 Jul 4. Review. PubMed PMID: 26141124.
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13: Heijman J, Dewenter M, El-Armouche A, Dobrev D. Function and regulation of serine/threonine phosphatases in the healthy and diseased heart. J Mol Cell Cardiol. 2013 Nov;64:90-8. doi: 10.1016/j.yjmcc.2013.09.006. Epub 2013 Sep 16. Review. PubMed PMID: 24051368.
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